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The map label for this gene is mutS [H]

Identifier: 125623630

GI number: 125623630

Start: 767303

End: 769633

Strand: Direct

Name: mutS [H]

Synonym: llmg_0778

Alternate gene names: 125623630

Gene position: 767303-769633 (Clockwise)

Preceding gene: 125623629

Following gene: 125623631

Centisome position: 30.33

GC content: 35.99

Gene sequence:

>2331_bases
ATGAATAAAAAAATTCTCCAAATATTGGAATATGATAAAGTCAAAGAGCAGTTTATGAATGCTTTGACGACAGCGCAGGG
TCAGAAAGAATTATCTGACTTAGTCCCCTTGACCGATAAAGATAAGATTCAGCTCCTTTTTGATGAGGTTGCTGATTTTC
GCTTATTGACTCAAGAAAATGGTTTGTTAAATTTAGGGAAAACAAATGATTTAACTGAGATTCTGCGACGCTTGGAGCTT
GAAGCGAGTCTTTCAGGAAAAGAATTTGTTGAAATAAAAAAAGTGATTCAACTTGGAATCAATATTCAACGTTTTTTTGA
CGAAGCTGAAAATGTTGAAACACCATCACTAAATATTACTTTAGAAAAATTGGTTGATTTATCAGGGCTGATTAAGAAAT
TAGAAATCTTTGATAATGCCGGTAGTCTTTACGATAATGCAAGTCTGGAATTGATGCACATTCGTGCCTCAATCAAGAGT
CATCAGTCAGAAATTCGTAAAATTATGCAAGAAATGCTGACAAAAAATCTCTCATCTTTGAGTGAAAATGTCATCACTAT
TCGAAATGACCGTCAAGTTCTTCCTGTAAAAGCAGAAAATAAAAATAAAATTGCCGGAGTCGTTCATGATATGTCCGCTT
CTGGTCAAACGCTTTATATTGAACCGAATGCGGTAGTTTCACTTAATAATAAGCTTAATCAAAAACGAATTGAAGAACGA
CAAGAAATTACAAGAATTTATCGAGAACTTGCTGAAGAATTAAAACCTTATAGTTTTGATATTCGGCAAAATGCTTGGCT
GATTGGACATATTGACTTTGTTCGGGCAAAATATCTTTATTTGACAGCTAATAAGGCAAGCTTGCCTGCTTTAACAAATG
ATAAAGATATTATCTTGTTTGCCGCTCGTCATCCTTTGATTGATGCAAAAATGGTTGTGGCAAATGATATTAAATTTGAC
AAAACACTCAATACAATTGTCATTACGGGGCCGAATACAGGTGGTAAAACTATTACCCTGAAAACAGTTGGTTTACTTAC
TATTTTAGCTCAATCAGGTTTGCCAATTTTAGCGGAGGATGGCAGCCGTATTCATCTTTTTGATGACATTTTTGCTGATA
TTGGTGATGAACAATCAATTGAACAAAGTTTGTCAACTTTCTCAAGTCATATGACGAATATTGTACAAATTTTAGCTCAG
GCTGATGAAAATAGTTTGGTCTTGTTTGATGAACTTGGAGCAGGGACTGACCCGAAAGAAGGGGCAGCACTTGCGATTGC
CATTCTTGAAAATTTACGAAAACGAAATGTTAAAACAATGGCAAGTACCCACTATCCAGAGCTGAAAGCTTATGGTGTGG
AAACTCAGCAAGTGATCAATGCCAGTATGGAATTTAACATTGATAAAATGCAGCCGACTTATCATTTGCAACTTGGTGTG
CCCGGGCGCTCAAATGCTTTGGAAATTTCAAGACGTTTGGGCTTACCGGAAACGATTATTTCTGAGGCTGGTCAGCAAAT
TTCAGAGAGCGAACATGATGTCAATCAAATGATTGAAAAGTTGGAAGAAAAAACGCGTGAAGTCATTGAAAGTTCAAGAA
ATATCAAAAAAATTGAACGAGAAAATCAAAGTTTACATAAAGATTTGACGAAAGTTTATAATCAGATTAACCGCGAACGT
GACTTTGAATTAGAAAAAGCCCAAAAAGAAGCTCAAGAAGTAGTTAAAAAAGCGAGTCTTGAGGCTCAAGAAATCTTGAA
AAATCTTAATGATAAAGCGGCATTAAAGCCCCATGAAATCATCGCTGCTAGAAAAGAACTTGAGGGCTTAGCGCCAACCA
TTGATTTTTCAAAAAACAAGGTTTTGAAAAAAGCCAAGGCACAAAGAGGACTTAAGCAAGGGGCTGAGGTCAATGTTACT
TCTTATGGTCAGCGAGGAAAATTGATTCGTTTAGAAAAAGATGGCCGTTGGACAGTCCAAATGGGTTCAATTACTACTCG
TTTAAGTGAAGAAGAGTTTGAAGTCATTGAGACTCCTGAACAAATTCAAGCAAAAACTAAAAATGTCAGCAAAAAAGTAA
CTTCTAAGGTTAAAGCACAGCTAGATTTACGTGGGATGCGTTATGAAGAAGCAGAACTGGAATTGGACAATTATATTGAT
CAGGCTTTACTTGCAAATCTAATTCAAATTACGATTGTTCATGGGATTGGAACAGGTGTCATTCGAGAAATGGTACAGAA
AAAACTTCAAAAACATCGTCATATCAAATCTTATGAATATGCGCCAATCAATGCTGGAGGCTCTGGAGCAACCATTGCCA
TTTTGAAATAA

Upstream 100 bases:

>100_bases
GGAATCTTGCAAAACCTGTTTATTGAAAATATTGTCCATATTAATCCACTCGGATAAGTTTAGGGACAAATCTACAAAAA
TAAATTGAAATATAACTATA

Downstream 100 bases:

>100_bases
AAAATAAAGTATCTGAAAATCTATTTCCTTGAAATTTTAAGTGATTTACACTAGAATAGTCTTACTGAAGAAAATTATTT
CAATGAAGGAGATATAATGG

Product: DNA mismatch repair protein mutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MNKKILQILEYDKVKEQFMNALTTAQGQKELSDLVPLTDKDKIQLLFDEVADFRLLTQENGLLNLGKTNDLTEILRRLEL
EASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLNITLEKLVDLSGLIKKLEIFDNAGSLYDNASLELMHIRASIKS
HQSEIRKIMQEMLTKNLSSLSENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
QEITRIYRELAEELKPYSFDIRQNAWLIGHIDFVRAKYLYLTANKASLPALTNDKDIILFAARHPLIDAKMVVANDIKFD
KTLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAEDGSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVQILAQ
ADENSLVLFDELGAGTDPKEGAALAIAILENLRKRNVKTMASTHYPELKAYGVETQQVINASMEFNIDKMQPTYHLQLGV
PGRSNALEISRRLGLPETIISEAGQQISESEHDVNQMIEKLEEKTREVIESSRNIKKIERENQSLHKDLTKVYNQINRER
DFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEIIAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVT
SYGQRGKLIRLEKDGRWTVQMGSITTRLSEEEFEVIETPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK

Sequences:

>Translated_776_residues
MNKKILQILEYDKVKEQFMNALTTAQGQKELSDLVPLTDKDKIQLLFDEVADFRLLTQENGLLNLGKTNDLTEILRRLEL
EASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLNITLEKLVDLSGLIKKLEIFDNAGSLYDNASLELMHIRASIKS
HQSEIRKIMQEMLTKNLSSLSENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
QEITRIYRELAEELKPYSFDIRQNAWLIGHIDFVRAKYLYLTANKASLPALTNDKDIILFAARHPLIDAKMVVANDIKFD
KTLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAEDGSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVQILAQ
ADENSLVLFDELGAGTDPKEGAALAIAILENLRKRNVKTMASTHYPELKAYGVETQQVINASMEFNIDKMQPTYHLQLGV
PGRSNALEISRRLGLPETIISEAGQQISESEHDVNQMIEKLEEKTREVIESSRNIKKIERENQSLHKDLTKVYNQINRER
DFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEIIAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVT
SYGQRGKLIRLEKDGRWTVQMGSITTRLSEEEFEVIETPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK
>Mature_776_residues
MNKKILQILEYDKVKEQFMNALTTAQGQKELSDLVPLTDKDKIQLLFDEVADFRLLTQENGLLNLGKTNDLTEILRRLEL
EASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLNITLEKLVDLSGLIKKLEIFDNAGSLYDNASLELMHIRASIKS
HQSEIRKIMQEMLTKNLSSLSENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
QEITRIYRELAEELKPYSFDIRQNAWLIGHIDFVRAKYLYLTANKASLPALTNDKDIILFAARHPLIDAKMVVANDIKFD
KTLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAEDGSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVQILAQ
ADENSLVLFDELGAGTDPKEGAALAIAILENLRKRNVKTMASTHYPELKAYGVETQQVINASMEFNIDKMQPTYHLQLGV
PGRSNALEISRRLGLPETIISEAGQQISESEHDVNQMIEKLEEKTREVIESSRNIKKIERENQSLHKDLTKVYNQINRER
DFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEIIAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVT
SYGQRGKLIRLEKDGRWTVQMGSITTRLSEEEFEVIETPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=396, Percent_Identity=26.5151515151515, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI36949366, Length=257, Percent_Identity=30.7392996108949, Blast_Score=103, Evalue=8e-22,
Organism=Homo sapiens, GI4557761, Length=535, Percent_Identity=24.6728971962617, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4504191, Length=274, Percent_Identity=29.1970802919708, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI26638666, Length=218, Percent_Identity=32.1100917431193, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI4505253, Length=218, Percent_Identity=32.1100917431193, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI26638664, Length=222, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI262231786, Length=142, Percent_Identity=40.1408450704225, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789089, Length=313, Percent_Identity=28.4345047923323, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17508445, Length=283, Percent_Identity=29.6819787985866, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=250, Percent_Identity=28.8, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508447, Length=267, Percent_Identity=26.9662921348315, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539736, Length=252, Percent_Identity=24.6031746031746, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=323, Percent_Identity=24.7678018575851, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324482, Length=325, Percent_Identity=24.3076923076923, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=229, Percent_Identity=31.0043668122271, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321109, Length=243, Percent_Identity=27.5720164609054, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=291, Percent_Identity=25.4295532646048, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=305, Percent_Identity=25.9016393442623, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584320, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664545, Length=232, Percent_Identity=31.8965517241379, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87379; Mature: 87379

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILQILEYDKVKEQFMNALTTAQGQKELSDLVPLTDKDKIQLLFDEVADFRLLTQEN
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCC
GLLNLGKTNDLTEILRRLELEASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLNIT
CEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEE
LEKLVDLSGLIKKLEIFDNAGSLYDNASLELMHIRASIKSHQSEIRKIMQEMLTKNLSSL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
SENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
HCCEEEEECCCEEEEEECCCCCCHHHEEEECCCCCCEEEECCCEEEEECCHHHHHHHHHH
QEITRIYRELAEELKPYSFDIRQNAWLIGHIDFVRAKYLYLTANKASLPALTNDKDIILF
HHHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHEEEEEEEEECCCCCCCCCCCCCEEEE
AARHPLIDAKMVVANDIKFDKTLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAED
EECCCCCCCEEEEECCCEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCCCEEEECC
GSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVQILAQADENSLVLFDELGAGTDPKE
CCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
GAALAIAILENLRKRNVKTMASTHYPELKAYGVETQQVINASMEFNIDKMQPTYHLQLGV
CHHHHHHHHHHHHHCCHHHHHHCCCCCHHCCCCCHHHHHHHHHEECEECCCCEEEEEECC
PGRSNALEISRRLGLPETIISEAGQQISESEHDVNQMIEKLEEKTREVIESSRNIKKIER
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ENQSLHKDLTKVYNQINRERDFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHH
IAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVTSYGQRGKLIRLEKDGRWTVQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEEE
MGSITTRLSEEEFEVIETPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
ECCCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNKKILQILEYDKVKEQFMNALTTAQGQKELSDLVPLTDKDKIQLLFDEVADFRLLTQEN
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCC
GLLNLGKTNDLTEILRRLELEASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLNIT
CEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEE
LEKLVDLSGLIKKLEIFDNAGSLYDNASLELMHIRASIKSHQSEIRKIMQEMLTKNLSSL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
SENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
HCCEEEEECCCEEEEEECCCCCCHHHEEEECCCCCCEEEECCCEEEEECCHHHHHHHHHH
QEITRIYRELAEELKPYSFDIRQNAWLIGHIDFVRAKYLYLTANKASLPALTNDKDIILF
HHHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHEEEEEEEEECCCCCCCCCCCCCEEEE
AARHPLIDAKMVVANDIKFDKTLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAED
EECCCCCCCEEEEECCCEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCCCEEEECC
GSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVQILAQADENSLVLFDELGAGTDPKE
CCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
GAALAIAILENLRKRNVKTMASTHYPELKAYGVETQQVINASMEFNIDKMQPTYHLQLGV
CHHHHHHHHHHHHHCCHHHHHHCCCCCHHCCCCCHHHHHHHHHEECEECCCCEEEEEECC
PGRSNALEISRRLGLPETIISEAGQQISESEHDVNQMIEKLEEKTREVIESSRNIKKIER
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ENQSLHKDLTKVYNQINRERDFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHH
IAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVTSYGQRGKLIRLEKDGRWTVQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEEE
MGSITTRLSEEEFEVIETPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
ECCCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]