Click here to switch to the map view.

The map label for this gene is eriC [H]

Identifier: 125623612

GI number: 125623612

Start: 745928

End: 747466

Strand: Direct

Name: eriC [H]

Synonym: llmg_0758

Alternate gene names: 125623612

Gene position: 745928-747466 (Clockwise)

Preceding gene: 125623611

Following gene: 125623614

Centisome position: 29.49

GC content: 37.17

Gene sequence:

>1539_bases
ATGAAATTAAAAGATATAGAAAAATCAACAAATAAAAATCTTTATCTGCTTTTTCTAAGTGTACTCGTGGGCTTGACTGC
GGGTTTTTTGGCCAGTCTTTATCGGTTGGCCTTGGAAAAAGCTGAAAATTTAGGCTTGGGTATTTATAGTTTTACCAGTT
CACATCTTATTTTTATTCCCCTTCTTATTTTGGGTCTTGTTCTTTTGGCTTTGCTTATTAGTTTTTTAATGACAAGATAT
CCAATGAGTTCAGGTTCAGGAATTCCACAAGTCAAAGGTCAGTTGCAGGGTTATTTTAAAAACAATTGGTTTACGACTGC
TTTTGCTAAATTTATCGCGGGAACTTTGGCAATGTTTGCGGGACTTTCTCTTGGTCGTGAAGGACCTTCGGTTCAACTTG
GAGCTTCAATGGGTCAAATGGTTTCTAGTCGATTGGCCGAAACCGAACGCCATAAAAGGATTCTAATTGCCTCTGGGGCA
TCTGCTGGTTTGTCTGCGGCTTTCAATGCGCCATTGTCAGGTGTGATGTTCACTCTGGAAGAAGTCTTTAAATATTTCTC
TCCTTTGATTTTACTCACTTGTATGACCTCAGCAATGGCTGCTGATATGGTTGCACGATTAATGTTTGGGAGCGGACCAG
TTTTTCATTTTCAAATTGTTGGTTCTATTGACCTGTCAAATTATTGGTTGCTTATTATTTTAGGAATTATTTTAGGGTTC
TTTGGTGCTTTTTATAATTGGACCCTTTTAACAAGCCAAAGTTTGATGAAGAAAATTAAAAGTCCTTTCTTACGCGTTTT
AATTACGCTTTTAATCGTCGGAGTGACAGGCTTGGTTTTTCCAAGTATAATTGGAAGTGGCCATCACTTAATGGATTCTT
TTAGTTTGGGCATGGGGCTTGGTTTTCTTTGTCTAGTCCTCATTGGAAAGTATCTTATTTCAATGATTTCTTATGCTTCA
GTTGTTCCTGGCGGAATTTTCTTCCCATTATTAGTTTTAGGAGCAAGTCTGGGTGCTGTCTTTGCTACAATTGTGATTTC
AATTTTTCATCTTCCGAGTCATTTATTTGCCAATCTAGTGATTTTGGCAATGGCAGGAACCTTTACTGCTATCGTGCGAG
CGCCAATGACTGGAATTTTGCTCTTAGTGGAAATGACAGGGTCATTTGACCATTTGCTTCCTTTGGCATTTGTTTCATTG
ATTGCATACGTTGTAGCAGATTTATTAAAAGCAGAACCGATTTATGATTTATTGCTAGAAAAAATGTTGAAAGAAAAAGA
AATAGAGATTGATGATTCTGATAAACAGATGATGTTTGAAACAATTGTTCAATTTGATTCAATTGCTGACCGCAAGAAAT
TATCAGAGATTAATTTACCAGAAGGTTGTTTACTTGTGTCAGTGCATCGTTCGGGAAAAGATATTATTCCACATGGAGAT
ACCGAGTTACAGGCTGGAGATTATCTAACATTTTTGATTAAAAGGGAAGATGAAGTGCTTGCTCGTGAGCAGCTTCGTCT
GGTTCTGAATGAAAAATAA

Upstream 100 bases:

>100_bases
TGTGTATATTATTAAAAGTACAAAACATAAGGAATCTATTTTATGGTATAATAATCTTGCTTAAAAATTTATTAAAATAA
GCGTTAGTAGGGAAGTAGTA

Downstream 100 bases:

>100_bases
AAAAAGTGATATCTATCACTTTTTTTATTTTGTTAAATATTGCCAAATGATTGAGAGAAGTAGACTAAAGGCATAGGCGC
TATTAAATAAGACCATGTTT

Product: putative chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAENLGLGIYSFTSSHLIFIPLLILGLVLLALLISFLMTRY
PMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGA
SAGLSAAFNAPLSGVMFTLEEVFKYFSPLILLTCMTSAMAADMVARLMFGSGPVFHFQIVGSIDLSNYWLLIILGIILGF
FGAFYNWTLLTSQSLMKKIKSPFLRVLITLLIVGVTGLVFPSIIGSGHHLMDSFSLGMGLGFLCLVLIGKYLISMISYAS
VVPGGIFFPLLVLGASLGAVFATIVISIFHLPSHLFANLVILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLAFVSL
IAYVVADLLKAEPIYDLLLEKMLKEKEIEIDDSDKQMMFETIVQFDSIADRKKLSEINLPEGCLLVSVHRSGKDIIPHGD
TELQAGDYLTFLIKREDEVLAREQLRLVLNEK

Sequences:

>Translated_512_residues
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAENLGLGIYSFTSSHLIFIPLLILGLVLLALLISFLMTRY
PMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGA
SAGLSAAFNAPLSGVMFTLEEVFKYFSPLILLTCMTSAMAADMVARLMFGSGPVFHFQIVGSIDLSNYWLLIILGIILGF
FGAFYNWTLLTSQSLMKKIKSPFLRVLITLLIVGVTGLVFPSIIGSGHHLMDSFSLGMGLGFLCLVLIGKYLISMISYAS
VVPGGIFFPLLVLGASLGAVFATIVISIFHLPSHLFANLVILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLAFVSL
IAYVVADLLKAEPIYDLLLEKMLKEKEIEIDDSDKQMMFETIVQFDSIADRKKLSEINLPEGCLLVSVHRSGKDIIPHGD
TELQAGDYLTFLIKREDEVLAREQLRLVLNEK
>Mature_512_residues
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAENLGLGIYSFTSSHLIFIPLLILGLVLLALLISFLMTRY
PMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGA
SAGLSAAFNAPLSGVMFTLEEVFKYFSPLILLTCMTSAMAADMVARLMFGSGPVFHFQIVGSIDLSNYWLLIILGIILGF
FGAFYNWTLLTSQSLMKKIKSPFLRVLITLLIVGVTGLVFPSIIGSGHHLMDSFSLGMGLGFLCLVLIGKYLISMISYAS
VVPGGIFFPLLVLGASLGAVFATIVISIFHLPSHLFANLVILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLAFVSL
IAYVVADLLKAEPIYDLLLEKMLKEKEIEIDDSDKQMMFETIVQFDSIADRKKLSEINLPEGCLLVSVHRSGKDIIPHGD
TELQAGDYLTFLIKREDEVLAREQLRLVLNEK

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=427, Percent_Identity=25.9953161592506, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI55770840, Length=427, Percent_Identity=25.9953161592506, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4557473, Length=427, Percent_Identity=26.6978922716628, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI189217923, Length=427, Percent_Identity=26.6978922716628, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI189217921, Length=427, Percent_Identity=26.6978922716628, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI153252026, Length=438, Percent_Identity=23.7442922374429, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI283806622, Length=439, Percent_Identity=23.6902050113895, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI283806618, Length=439, Percent_Identity=23.6902050113895, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI156104869, Length=439, Percent_Identity=23.6902050113895, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786350, Length=444, Percent_Identity=31.5315315315315, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI87081943, Length=328, Percent_Identity=27.1341463414634, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532615, Length=398, Percent_Identity=25.1256281407035, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996455, Length=430, Percent_Identity=23.953488372093, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996452, Length=430, Percent_Identity=23.953488372093, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980828, Length=572, Percent_Identity=23.4265734265734, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980824, Length=572, Percent_Identity=23.4265734265734, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980820, Length=575, Percent_Identity=23.4782608695652, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559050, Length=511, Percent_Identity=22.8962818003914, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71985148, Length=148, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71985141, Length=148, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=408, Percent_Identity=25.9803921568627, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24665008, Length=428, Percent_Identity=24.7663551401869, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551566, Length=414, Percent_Identity=25.3623188405797, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI161078208, Length=407, Percent_Identity=23.3415233415233, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573073, Length=407, Percent_Identity=23.3415233415233, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281361606, Length=407, Percent_Identity=23.3415233415233, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573075, Length=407, Percent_Identity=23.3415233415233, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28573071, Length=407, Percent_Identity=23.3415233415233, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281361608, Length=407, Percent_Identity=23.3415233415233, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 55925; Mature: 55925

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAENLGLGIYSFTSSHLIFIP
CCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCHHHHHH
LLILGLVLLALLISFLMTRYPMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGASAGLSAAFNAPLSGVMFTLE
HHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHCCCHHHHHHHHH
EVFKYFSPLILLTCMTSAMAADMVARLMFGSGPVFHFQIVGSIDLSNYWLLIILGIILGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHH
FGAFYNWTLLTSQSLMKKIKSPFLRVLITLLIVGVTGLVFPSIIGSGHHLMDSFSLGMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GFLCLVLIGKYLISMISYASVVPGGIFFPLLVLGASLGAVFATIVISIFHLPSHLFANLV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLAFVSLIAYVVADLLKAEPIYDLLLE
HHHHHHHHHHHHHCCHHHHEEHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KMLKEKEIEIDDSDKQMMFETIVQFDSIADRKKLSEINLPEGCLLVSVHRSGKDIIPHGD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCC
TELQAGDYLTFLIKREDEVLAREQLRLVLNEK
CCCCCCCEEEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAENLGLGIYSFTSSHLIFIP
CCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCHHHHHH
LLILGLVLLALLISFLMTRYPMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGASAGLSAAFNAPLSGVMFTLE
HHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHCCCHHHHHHHHH
EVFKYFSPLILLTCMTSAMAADMVARLMFGSGPVFHFQIVGSIDLSNYWLLIILGIILGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHH
FGAFYNWTLLTSQSLMKKIKSPFLRVLITLLIVGVTGLVFPSIIGSGHHLMDSFSLGMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GFLCLVLIGKYLISMISYASVVPGGIFFPLLVLGASLGAVFATIVISIFHLPSHLFANLV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLAFVSLIAYVVADLLKAEPIYDLLLE
HHHHHHHHHHHHHCCHHHHEEHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KMLKEKEIEIDDSDKQMMFETIVQFDSIADRKKLSEINLPEGCLLVSVHRSGKDIIPHGD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCC
TELQAGDYLTFLIKREDEVLAREQLRLVLNEK
CCCCCCCEEEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA