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The map label for this gene is serS [H]

Identifier: 125623578

GI number: 125623578

Start: 706170

End: 707441

Strand: Reverse

Name: serS [H]

Synonym: llmg_0722

Alternate gene names: 125623578

Gene position: 707441-706170 (Counterclockwise)

Preceding gene: 125623579

Following gene: 125623573

Centisome position: 27.97

GC content: 38.84

Gene sequence:

>1272_bases
ATGCTTGATATTAAAAAAATTCGTGCCGATTTTGATGGCGTTGCTGCAAAATTAGCTACTCGTGGTGTTGAAAAAGAAAA
ACTTGAAAAACTTCATGACTTAGACATTAAACGTCGTGAACTTATTGTAAAATCTGAGGCTTTGAAAGCTGAACGCAATA
GTGTTTCTGATGAAATTTCCCAAGTAAAACGTGCAAAAGGTGATGCTAGCACACAAATTGCAGCGATGCAAAAAGTTTCT
GCTGAAATCAAAGCCATTGACGCTGAACTTGCTGAAATCGAAGAAAACTTGAATGAAATCATCATTATGTTGCCAAACCT
TCCTCATGAAAGTACGCCAATTGGTGCTGATGAAGATGATAATGTTGAGGTTCGTCGTGTTGGTCAAACTCCAACTTTCA
ATTTTGAACCTAAAGCTCATTGGGATTTGGGTGAAGATTTAGGAATTTTGGACTGGGAACGTGGTGGTAAAGTCACTGGT
TCACGTTTCCTTTTCTACAAAGGTGCTGGCGCAAGACTTGAACGTGCCCTTTATAACTTCATGCTTGATGAGCATGGTAA
AGAAGGCTATACCGAAATGATCACTCCTTATATGGTTAATCAAGAGTCAATGTTTGGAACTGGTCAATATCCTAAATTTA
AAGAAGACACTTTTGAATTGAAAGATGATCGTGGTTTTGTCTTAATTCCAACTGCTGAAGTTCCTTTGACTAACTACTAC
CGTGGCGAAATTTTGGACGGTAGCGAATTACCAATTAAATTTACAGCGATGAGCCCTTCTTTCCGTTCTGAAGCTGGTTC
TGCTGGTCGCGATACTCGTGGTTTGATTCGTTTGCACCAATTCCACAAGGTTGAAATGGTTAAATTTGCAAAACCTGACC
AATCTTATGACGAACTTGAAAAAATGACAGCAAATGCTGAAAACATTCTTCAAAAATTGGGCCTTGCTTATCGTGTTGTG
GCTTTATCTACTGGCGATATGGGATTTTCTGCTGCTAAAACTTATGATTTAGAAGTTTGGATTCCTGCGCAAAATACTTA
TCGTGAAATTTCTTCATGTTCAAACTGTGAAGATTTCCAAGCCCGTCGTGCCCAAATTCGTTATCGTGATGAAGATGGTA
AAGTTCAGCTCCTTCACACTTTGAATGGTTCTGGACTTGCTGTTGGACGTACTGTGGCTGCTATCCTTGAAAATTATCAA
AATGAAGATGGCTCAATCACTGTTCCTGAAATCCTTCGTCCTTATATGGGTGGACTTGAAGTAATTAAATAA

Upstream 100 bases:

>100_bases
CGCTTTTTTTCTACTGACAAAAGATTTTTTGCTTACTTGTAGCGTTTAAATTTTCGTCAGTAGATTGATTATAAAATTAA
CAAAAAATAAAGGAGAGCTT

Downstream 100 bases:

>100_bases
TAAAAAAATCTACTGACAGAAATTTTTATAACTTGTCAGTAGATTTTTTTATTGTTCTTACCGATAGAGACTCACTCAAA
TCTTTTTTATTATCATTGTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEISQVKRAKGDASTQIAAMQKVS
AEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDDNVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTG
SRFLFYKGAGARLERALYNFMLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
RGEILDGSELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELEKMTANAENILQKLGLAYRVV
ALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQARRAQIRYRDEDGKVQLLHTLNGSGLAVGRTVAAILENYQ
NEDGSITVPEILRPYMGGLEVIK

Sequences:

>Translated_423_residues
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEISQVKRAKGDASTQIAAMQKVS
AEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDDNVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTG
SRFLFYKGAGARLERALYNFMLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
RGEILDGSELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELEKMTANAENILQKLGLAYRVV
ALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQARRAQIRYRDEDGKVQLLHTLNGSGLAVGRTVAAILENYQ
NEDGSITVPEILRPYMGGLEVIK
>Mature_423_residues
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEISQVKRAKGDASTQIAAMQKVS
AEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDDNVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTG
SRFLFYKGAGARLERALYNFMLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
RGEILDGSELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELEKMTANAENILQKLGLAYRVV
ALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQARRAQIRYRDEDGKVQLLHTLNGSGLAVGRTVAAILENYQ
NEDGSITVPEILRPYMGGLEVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=371, Percent_Identity=38.544474393531, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI225579074, Length=382, Percent_Identity=33.5078534031414, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI8923421, Length=395, Percent_Identity=32.6582278481013, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=55.1162790697674, Blast_Score=451, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17539260, Length=386, Percent_Identity=34.7150259067358, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17542084, Length=338, Percent_Identity=28.1065088757396, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=388, Percent_Identity=34.2783505154639, Blast_Score=228, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6321799, Length=382, Percent_Identity=30.8900523560209, Blast_Score=208, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24581334, Length=339, Percent_Identity=37.1681415929204, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=32.9479768786127, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47515; Mature: 47515

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVKRAKGDASTQIAAMQKVSAEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCC
NVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTGSRFLFYKGAGARLERALYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHH
MLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
HHHHCCCCCHHHHCCCEEECCHHCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCC
RGEILDGSELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELE
CCEEECCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHH
KMTANAENILQKLGLAYRVVALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQ
HHHCCHHHHHHHHCHHEEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCHHHH
ARRAQIRYRDEDGKVQLLHTLNGSGLAVGRTVAAILENYQNEDGSITVPEILRPYMGGLE
HHHHEEEEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCHH
VIK
HCC
>Mature Secondary Structure
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVKRAKGDASTQIAAMQKVSAEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCC
NVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTGSRFLFYKGAGARLERALYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHH
MLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
HHHHCCCCCHHHHCCCEEECCHHCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCC
RGEILDGSELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELE
CCEEECCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHH
KMTANAENILQKLGLAYRVVALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQ
HHHCCHHHHHHHHCHHEEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCHHHH
ARRAQIRYRDEDGKVQLLHTLNGSGLAVGRTVAAILENYQNEDGSITVPEILRPYMGGLE
HHHHEEEEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCHH
VIK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]