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The map label for this gene is rnz [H]

Identifier: 125623465

GI number: 125623465

Start: 591748

End: 592671

Strand: Direct

Name: rnz [H]

Synonym: llmg_0604

Alternate gene names: 125623465

Gene position: 591748-592671 (Clockwise)

Preceding gene: 125623461

Following gene: 125623466

Centisome position: 23.39

GC content: 40.04

Gene sequence:

>924_bases
ATGGAAATCCAATTTTTAGGAACTGGGGCAGGTCAGCCCTCGAAATCAAGAAACACTCAAGCGATTGCTTTAAAAATGCT
TGATGAACGTAATGAAATTTGGCTTTTTGATTGTGGTGAAGCTAGTCAACATCAAATTTTAAATACAGCAATTAAACCTC
GAAAAATTACAAAGATTTTTATTACGCATTTGCATGGTGACCATATTTTTGGTCTCCCTGGTTTTTTGTCTAGCCGAAGT
TTTCAAAGCTCAGATGAGCAGACTGATTTGGACCTCTATGGTCCTGTAGGGATTAAAGAGTTTGTTTTAGCGGGGCTTAG
AATTTCAGGTTCACATTTAGGTTATCGGATTAATTTTCATGAGATTGATTCAGCAGGAAAAATCTTTGAAGATGATTCTT
TTGAAGTTTATACGGATTTGCTTGACCATACCATTTTCTGCTTGGGTTATCGCGTAGTAGAGAAAAATCGGGTAGGTGAA
CTTGATGCTAATGCTTTAAAAGAAGCTGGACTTCCTTTTGGACCTCTTTTTGGTAAAATTAAAAAAGGAGAAGTCGTCGA
CTATGACGGAAAAACCTTTGACCCTAAGGACTATATCGGAGCTGATAAAGTAGGGAAAATCGTGACGATTTTAGGAGACA
CGCGAAAAACAAACACAGCGGTGCGTTTGGCTTGGCAAGCAGATTTACTGGTGCATGAGGCAACTTATGAGGCCGCTGAG
AGTAAAATGGCCAGAGCTCATGGGCATTCAACGACTAAGCAAGCGGCTGATGTTGCTAAGGAAGCAGGCGTCAATCGTTT
ATTATTGACCCATATTAGTGCACGTTATGTTGGTCCTTTGGTAGGGCAATTGGTTCGTGAAGCGCAAGATGTTCACGCGA
ATACCTTTGTGGCCAAAGATTTATACGAGGAAAAAATTGGTTAA

Upstream 100 bases:

>100_bases
GGCTCACAATTTTTTCTTATTTTTGAAAAAATATTTCTCAAAGTTTAGAGAAAACAACGGTAAAAGCTAATGATTCTAAA
GCTTATGTTATGGAGGGTCA

Downstream 100 bases:

>100_bases
AAATATTGTAATTACAGGTGCAACTGGTGATATTGCAAAAGAAATTGTCAGCTTATTATCTAAAACAAATGACCATTTGA
TTTTGGTATCACGAAGTCGT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MEIQFLGTGAGQPSKSRNTQAIALKMLDERNEIWLFDCGEASQHQILNTAIKPRKITKIFITHLHGDHIFGLPGFLSSRS
FQSSDEQTDLDLYGPVGIKEFVLAGLRISGSHLGYRINFHEIDSAGKIFEDDSFEVYTDLLDHTIFCLGYRVVEKNRVGE
LDANALKEAGLPFGPLFGKIKKGEVVDYDGKTFDPKDYIGADKVGKIVTILGDTRKTNTAVRLAWQADLLVHEATYEAAE
SKMARAHGHSTTKQAADVAKEAGVNRLLLTHISARYVGPLVGQLVREAQDVHANTFVAKDLYEEKIG

Sequences:

>Translated_307_residues
MEIQFLGTGAGQPSKSRNTQAIALKMLDERNEIWLFDCGEASQHQILNTAIKPRKITKIFITHLHGDHIFGLPGFLSSRS
FQSSDEQTDLDLYGPVGIKEFVLAGLRISGSHLGYRINFHEIDSAGKIFEDDSFEVYTDLLDHTIFCLGYRVVEKNRVGE
LDANALKEAGLPFGPLFGKIKKGEVVDYDGKTFDPKDYIGADKVGKIVTILGDTRKTNTAVRLAWQADLLVHEATYEAAE
SKMARAHGHSTTKQAADVAKEAGVNRLLLTHISARYVGPLVGQLVREAQDVHANTFVAKDLYEEKIG
>Mature_307_residues
MEIQFLGTGAGQPSKSRNTQAIALKMLDERNEIWLFDCGEASQHQILNTAIKPRKITKIFITHLHGDHIFGLPGFLSSRS
FQSSDEQTDLDLYGPVGIKEFVLAGLRISGSHLGYRINFHEIDSAGKIFEDDSFEVYTDLLDHTIFCLGYRVVEKNRVGE
LDANALKEAGLPFGPLFGKIKKGEVVDYDGKTFDPKDYIGADKVGKIVTILGDTRKTNTAVRLAWQADLLVHEATYEAAE
SKMARAHGHSTTKQAADVAKEAGVNRLLLTHISARYVGPLVGQLVREAQDVHANTFVAKDLYEEKIG

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=319, Percent_Identity=39.1849529780564, Blast_Score=220, Evalue=1e-57,
Organism=Escherichia coli, GI87082078, Length=303, Percent_Identity=45.5445544554455, Blast_Score=262, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 33944; Mature: 33944

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIQFLGTGAGQPSKSRNTQAIALKMLDERNEIWLFDCGEASQHQILNTAIKPRKITKIF
CEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHCCCHHEEEEE
ITHLHGDHIFGLPGFLSSRSFQSSDEQTDLDLYGPVGIKEFVLAGLRISGSHLGYRINFH
EEEECCCEEECCCCHHCCCCCCCCCCCCCCEEECCCCHHHHHHHCCEEECCCCEEEEEEE
EIDSAGKIFEDDSFEVYTDLLDHTIFCLGYRVVEKNRVGELDANALKEAGLPFGPLFGKI
ECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHCCC
KKGEVVDYDGKTFDPKDYIGADKVGKIVTILGDTRKTNTAVRLAWQADLLVHEATYEAAE
CCCCEEECCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCEEEEEEEHHHEEEHHHHHHHH
SKMARAHGHSTTKQAADVAKEAGVNRLLLTHISARYVGPLVGQLVREAQDVHANTFVAKD
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYEEKIG
HHHHHCC
>Mature Secondary Structure
MEIQFLGTGAGQPSKSRNTQAIALKMLDERNEIWLFDCGEASQHQILNTAIKPRKITKIF
CEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHCCCHHEEEEE
ITHLHGDHIFGLPGFLSSRSFQSSDEQTDLDLYGPVGIKEFVLAGLRISGSHLGYRINFH
EEEECCCEEECCCCHHCCCCCCCCCCCCCCEEECCCCHHHHHHHCCEEECCCCEEEEEEE
EIDSAGKIFEDDSFEVYTDLLDHTIFCLGYRVVEKNRVGELDANALKEAGLPFGPLFGKI
ECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHCCC
KKGEVVDYDGKTFDPKDYIGADKVGKIVTILGDTRKTNTAVRLAWQADLLVHEATYEAAE
CCCCEEECCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCEEEEEEEHHHEEEHHHHHHHH
SKMARAHGHSTTKQAADVAKEAGVNRLLLTHISARYVGPLVGQLVREAQDVHANTFVAKD
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYEEKIG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]