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The map label for this gene is uvrB [H]

Identifier: 125623401

GI number: 125623401

Start: 532077

End: 534155

Strand: Direct

Name: uvrB [H]

Synonym: llmg_0534

Alternate gene names: 125623401

Gene position: 532077-534155 (Clockwise)

Preceding gene: 125623400

Following gene: 125623402

Centisome position: 21.04

GC content: 39.11

Gene sequence:

>2079_bases
ATGGCAATAGAAAGAATAACAGATAATAAATTTGAACTGGTTTCAAAATATGACCCGGCTGGTGACCAAGGTCAAGCGAT
TAGTGAACTCGTAGAAAATATTGAAAATGGAGAAAAAGCGCAAATTTTGCGTGGGGCAACTGGGACAGGAAAAACCTATA
CGATGAGTCAGGTCATTGCTCAAACGGGAAAACCGACTCTGGTCATGGCTCATAATAAAACACTGGCTGGTCAATTATAC
AGCGAATTTAAAGAATTTTTCCCAAATAATGCGGTTGAATATTTTGTATCCTATTATGATTATTATCAACCAGAAGCTTA
TGTACCAAGTTCTGACACATATATTGAAAAAGACAGTTCGGTCAATGATGAAATTGACAAATTGCGTCATAGCGCAACTT
CAAGTTTATTAGAGCGTAATGACGTCATTGTTGTGGCCTCTGTTTCTTGTATTTATGGTTTAGGTTCACCCAAAGAGTAT
CAAGATTCTGTGGTTTCATTGCGACCAGGACAAGAAATTTCTCGAGACCAACTTTTAAACGATTTGGTAGGGATTCAATT
TGAGCGTAATGATATTGACTTTCAACGGGGCTGTTTCCGGGTTCGTGGGGATGTTGTAGAAGTTTTTCCAGCCTCTCGTG
ATGAGCATGCCTTCCGTGTTGAATTTTTCGGTGATGAAATTGACCGCATTCGTGAAATTGAAGTATTGACTGGACAAGTT
TTAGGTGAAGTGGACCATTTGGCAATTTTCCCAGCGACACATTTCATGACAAATGACGACCGCATGGAAGAGTCCATTGC
CAAAATTGAAGCGGAATTAGAAGCACAATTGAAAGTTTTCCGTTCAGAAGGAAAGCTTCTTGAAGCTCAACGTTTAGAAC
AAAGAACTAACTATGATATTGAAATGCTTCGTGAAATGGGTTATTGTAATGGGGTCGAAAACTATTCACGTCATATGGAC
GGACGTGAGGAAGGCGAACCGCCTTATACCTTGCTTGATTTCTTCCCTGATGATTTCATGATTATGATTGATGAATCACA
CATGACAATGGGACAAGTTAAAGGAATGTATAATGGTGACAGAGCTCGTAAAGAAATGCTCTGTAACTATGGATTCCGTC
TGCCTTCAGCCCTTGATAACCGTCCTTTAAAACGTGAAGAATTTGAAAGCCATGTCCACCAAATTGTTTATGTTTCAGCG
ACTCCTGGCGATTATGAAATGGAACAGACCGATACCATTGTGGAACAAATTATTCGTCCGACAGGCTTGCTGGACCCTGT
CGTAGAAGTTCGACCAATGATGGGACAAATTGACGATTTAGTGGGTGAAATTCATAAACGAGCTGAGAAAAATGAGCGAG
TTTTTGTCACGACTTTGACGAAAAAAATGTCTGAAGATTTGACTGCCTACTTCAAAGAAATGGGGATTAAAGTCAAATAT
ATGCACTCAGATATCAAAACCTTAGAACGAACCGAAATTATTCGCGATTTACGTTTAGGAGTATTTGATGTTCTGGTGGG
AATTAATTTGCTTCGTGAAGGGATTGACGTTCCCGAAGTTTCTTTAGTAGCGATTTTGGACGCGGACAAAGAAGGATTTT
TGCGAAATGAACGTGGTTTGATTCAAACAATTGGCCGTGCGGCGCGTAATAGTGAAGGTCATGTTATTCTTTATTCTGAC
ATGGCTAAAGCCCTTGACGAAAATGATCCGGCAGATAAAGAAATCTTAGATAGTGGTTATTATACAGAATACGAGGGGAA
AAAATATAAAATTACACGTTCGATGAAACATGCAATGGATGAAACGGCAAGACGTCGTGACATTCAAATGGCGTATAATG
AAGAACATGGAATTACACCTCAAACCATCAAAAAAGAAATTCGTGATTTGATTGCTATTACTAAGAAAACAGATTCTGGT
GAGCTGGAAGAAGTTGATGCAAGTGCGATGAATAAGAAAGAACGCAAAGCTTTAGTCAAAAAACTTGAAAAAGAAATGCA
ACAAGCAGCAGCTGCGCTTGATTTTGAAGGAGCAGCTCAATTACGTGATATGGTTTTAGAATTAAGAGCAATGGATTAA

Upstream 100 bases:

>100_bases
ACTGAGATTTTAAAAATAGATTTTGGCTTTAAAAACGAGGTTTATCATCAAGCATTAGCTTATTTTTCAAACATCATAGA
AAAGAATTGAAGGAAAAAGA

Downstream 100 bases:

>100_bases
AAAAACTAATAAAAATTCACTTTTAAAGTGAATTTTTATTTTATATAAAGTATAATAGTGCAGGTTTTTTCCTGTTCAAT
CGTCTTTTTTAAATAATTAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MAIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIAQTGKPTLVMAHNKTLAGQLY
SEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEY
QDSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMD
GREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSA
TPGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSD
MAKALDENDPADKEILDSGYYTEYEGKKYKITRSMKHAMDETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSG
ELEEVDASAMNKKERKALVKKLEKEMQQAAAALDFEGAAQLRDMVLELRAMD

Sequences:

>Translated_692_residues
MAIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIAQTGKPTLVMAHNKTLAGQLY
SEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEY
QDSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMD
GREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSA
TPGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSD
MAKALDENDPADKEILDSGYYTEYEGKKYKITRSMKHAMDETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSG
ELEEVDASAMNKKERKALVKKLEKEMQQAAAALDFEGAAQLRDMVLELRAMD
>Mature_691_residues
AIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIAQTGKPTLVMAHNKTLAGQLYS
EFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQ
DSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQVL
GEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMDG
REEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSAT
PGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKYM
HSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSDM
AKALDENDPADKEILDSGYYTEYEGKKYKITRSMKHAMDETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGE
LEEVDASAMNKKERKALVKKLEKEMQQAAAALDFEGAAQLRDMVLELRAMD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=694, Percent_Identity=55.043227665706, Blast_Score=733, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79016; Mature: 78885

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIA
CCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHEEECCCCCCCCHHHHHHHH
QTGKPTLVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSS
HCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCC
VNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQDSVVSLRPGQEISRDQLLN
CCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEECCCCCCCCHHHHHH
DLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
HHHCCEEECCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDI
HCCCHHEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
EMLREMGYCNGVENYSRHMDGREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGD
HHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHCCCCCCH
RARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRP
HHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCC
TGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEE
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHH
IQTIGRAARNSEGHVILYSDMAKALDENDPADKEILDSGYYTEYEGKKYKITRSMKHAMD
HHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCHHHHCCCCEECCCCCEEEHHHHHHHHHH
ETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGELEEVDASAMNKKERKALVK
HHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHH
KLEKEMQQAAAALDFEGAAQLRDMVLELRAMD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIERITDNKFELVSKYDPAGDQGQAISELVENIENGEKAQILRGATGTGKTYTMSQVIA
CCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHEEECCCCCCCCHHHHHHHH
QTGKPTLVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSS
HCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCC
VNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQDSVVSLRPGQEISRDQLLN
CCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEECCCCCCCCHHHHHH
DLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
HHHCCEEECCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEAQLKVFRSEGKLLEAQRLEQRTNYDI
HCCCHHEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
EMLREMGYCNGVENYSRHMDGREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGD
HHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHCCCCCCH
RARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRP
HHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCC
TGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEE
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHH
IQTIGRAARNSEGHVILYSDMAKALDENDPADKEILDSGYYTEYEGKKYKITRSMKHAMD
HHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCHHHHCCCCEECCCCCEEEHHHHHHHHHH
ETARRRDIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGELEEVDASAMNKKERKALVK
HHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHH
KLEKEMQQAAAALDFEGAAQLRDMVLELRAMD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]