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The map label for this gene is nudH [H]

Identifier: 125623400

GI number: 125623400

Start: 531611

End: 532066

Strand: Direct

Name: nudH [H]

Synonym: llmg_0533

Alternate gene names: 125623400

Gene position: 531611-532066 (Clockwise)

Preceding gene: 125623397

Following gene: 125623401

Centisome position: 21.02

GC content: 33.11

Gene sequence:

>456_bases
ATGAAAGAATACAGACAAAATGTCGCAGCCATTATTCTCAATAAAGAAAACAAAATCTGGCTAGGTAAACGAGCAGACGG
AATGAATTGGGGCTTTCCTCAAGGCGGAATTGAAGCAGGAGAAAATCCTGAAAGTGCCATTATCCGAGAACTTTCAGAAG
AAATTGGCACGAAAAACTTTGAAATTATTGGACAATATCCAGGAACATTAAAATATGATTTTCCTAAAGACATGAAATTT
CCAACATGGACTTATGCAGGTCAAGAACAGCACTATTTTCTTGTTAGATTAGATGAGCAAGCAAAAATTGACCTTGAAAG
CCATCCTGAAGAAATTGAGTTTTCAAGATATCAATTTTTATCTTTAACTGAGATTTTAAAAATAGATTTTGGCTTTAAAA
ACGAGGTTTATCATCAAGCATTAGCTTATTTTTCAAACATCATAGAAAAGAATTGA

Upstream 100 bases:

>100_bases
TTAGCTGTGAAAATGGTAAAATTGTATTAGAAGATTAATAATGAAATGATTTTTTATATCTATAGAATTCAATACTAAAA
TAAATAAAAAGAGGATAAAA

Downstream 100 bases:

>100_bases
AGGAAAAAGAATGGCAATAGAAAGAATAACAGATAATAAATTTGAACTGGTTTCAAAATATGACCCGGCTGGTGACCAAG
GTCAAGCGATTAGTGAACTC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MKEYRQNVAAIILNKENKIWLGKRADGMNWGFPQGGIEAGENPESAIIRELSEEIGTKNFEIIGQYPGTLKYDFPKDMKF
PTWTYAGQEQHYFLVRLDEQAKIDLESHPEEIEFSRYQFLSLTEILKIDFGFKNEVYHQALAYFSNIIEKN

Sequences:

>Translated_151_residues
MKEYRQNVAAIILNKENKIWLGKRADGMNWGFPQGGIEAGENPESAIIRELSEEIGTKNFEIIGQYPGTLKYDFPKDMKF
PTWTYAGQEQHYFLVRLDEQAKIDLESHPEEIEFSRYQFLSLTEILKIDFGFKNEVYHQALAYFSNIIEKN
>Mature_151_residues
MKEYRQNVAAIILNKENKIWLGKRADGMNWGFPQGGIEAGENPESAIIRELSEEIGTKNFEIIGQYPGTLKYDFPKDMKF
PTWTYAGQEQHYFLVRLDEQAKIDLESHPEEIEFSRYQFLSLTEILKIDFGFKNEVYHQALAYFSNIIEKN

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=154, Percent_Identity=31.1688311688312, Blast_Score=80, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17662; Mature: 17662

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYRQNVAAIILNKENKIWLGKRADGMNWGFPQGGIEAGENPESAIIRELSEEIGTKNF
CCHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
EIIGQYPGTLKYDFPKDMKFPTWTYAGQEQHYFLVRLDEQAKIDLESHPEEIEFSRYQFL
EEEECCCCEEEECCCCCCCCCCEEECCCCCEEEEEEECCCCEECCCCCCCCCCHHHHHHH
SLTEILKIDFGFKNEVYHQALAYFSNIIEKN
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEYRQNVAAIILNKENKIWLGKRADGMNWGFPQGGIEAGENPESAIIRELSEEIGTKNF
CCHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
EIIGQYPGTLKYDFPKDMKFPTWTYAGQEQHYFLVRLDEQAKIDLESHPEEIEFSRYQFL
EEEECCCCEEEECCCCCCCCCCEEECCCCCEEEEEEECCCCEECCCCCCCCCCHHHHHHH
SLTEILKIDFGFKNEVYHQALAYFSNIIEKN
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA