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The map label for this gene is cysK [H]

Identifier: 125623375

GI number: 125623375

Start: 499981

End: 500913

Strand: Reverse

Name: cysK [H]

Synonym: llmg_0508

Alternate gene names: 125623375

Gene position: 500913-499981 (Counterclockwise)

Preceding gene: 125623377

Following gene: 125623374

Centisome position: 19.8

GC content: 41.91

Gene sequence:

>933_bases
ATGACAAAAATCTATGAAAATATTACCGAACTGATTGGACATACTCCTATCATTAAATTACAGAATGTCCCAGCCGATAG
CGCTGATGTTTATGTTAAGCTTGAAGCTTTTAACCCTGGCGGTTCCGTCAAGGACCGGATTGCTCTTTCTATGATTCGCG
CCGCTGAAGCTGATGGCCGCTTACAGGCTGGCGGAACAATTGTTGAACCCACTTCTGGTAATACTGGAATTGGCTTGGCC
TTTGTTGGTTCCGCTCTTGGCTACAAGGTCGTGATTGTCATGCCAGAGTCATTCTCACTTGAACGTCGTAAATTGATTCA
AGCTTATGGTGCTCAGTTGGTTTTAACCCCTGCTAGTGGTGGGATGAAAGCTGCAATTGCCAAAGCAAAAGAACTTTCAG
AAACAGAAGGCTATTTTCTAGCCATGCAATTTGAAAATCCAGCAAATCCTGAGGTTCATGAAAAAACAACTGGTGCCGAA
ATTATCGACGCTTTTGGCCCAACTGGACTTGATGCTTTTGTCGCAGGAGCAGGGACTGGAGGAACAATAACAGGAGTCTC
TCACGCCTTAAAAAAAGTCAATCCAAATATTAAAACTTATGTTGTAGAAGCTGATGAATCTGCTATTCTCTCGGGCGAAC
CTGCTGGACCTCATAAAATTCAAGGAATTTCTGCTGGTTTCATTCCTGAAAATCTTGATACCAAATCTTATGATGAGATC
ATTCGTGTCAAAGGAGAGGATGCTATTTTAACTGCTCGTCATCTCGGGGGGAAAGAAGGATTTTTGGTTGGAATTTCTTC
TGGTGCAGCCATTTATGCCGCTCTCGAAGTAGCAAAAAAATTAGGTAAAGGTAAAAAAGTGTTAGCCATAGCTCCTGATA
ATGGTGAACGTTACTTGTCAACTGCTCTTTACGATTTTGATTCTGAAAAATAA

Upstream 100 bases:

>100_bases
TAAAATTTCATTGTCATAAATTTTTTTTAGAGCCATGATTATAATATTAGGAGGCAAAATTTTTTATTTGAGTTATAATG
AAAATAAAGGAGCCAAAAAA

Downstream 100 bases:

>100_bases
AATAAATAGTTACTGACAGAAACTTAAGAATAACCATCAGCTAAAAATTCTGATTGGTTTCTTCTAAATTTTTCTGTCAG
TATTTTTTTCTAAAATCTAA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTKIYENITELIGHTPIIKLQNVPADSADVYVKLEAFNPGGSVKDRIALSMIRAAEADGRLQAGGTIVEPTSGNTGIGLA
FVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASGGMKAAIAKAKELSETEGYFLAMQFENPANPEVHEKTTGAE
IIDAFGPTGLDAFVAGAGTGGTITGVSHALKKVNPNIKTYVVEADESAILSGEPAGPHKIQGISAGFIPENLDTKSYDEI
IRVKGEDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLSTALYDFDSEK

Sequences:

>Translated_310_residues
MTKIYENITELIGHTPIIKLQNVPADSADVYVKLEAFNPGGSVKDRIALSMIRAAEADGRLQAGGTIVEPTSGNTGIGLA
FVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASGGMKAAIAKAKELSETEGYFLAMQFENPANPEVHEKTTGAE
IIDAFGPTGLDAFVAGAGTGGTITGVSHALKKVNPNIKTYVVEADESAILSGEPAGPHKIQGISAGFIPENLDTKSYDEI
IRVKGEDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLSTALYDFDSEK
>Mature_309_residues
TKIYENITELIGHTPIIKLQNVPADSADVYVKLEAFNPGGSVKDRIALSMIRAAEADGRLQAGGTIVEPTSGNTGIGLAF
VGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASGGMKAAIAKAKELSETEGYFLAMQFENPANPEVHEKTTGAEI
IDAFGPTGLDAFVAGAGTGGTITGVSHALKKVNPNIKTYVVEADESAILSGEPAGPHKIQGISAGFIPENLDTKSYDEII
RVKGEDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLSTALYDFDSEK

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=36.8253968253968, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=36.8253968253968, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=36.8253968253968, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI11345492, Length=204, Percent_Identity=28.4313725490196, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788754, Length=323, Percent_Identity=50.7739938080495, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=39.4648829431438, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1790207, Length=241, Percent_Identity=28.6307053941909, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=47.1571906354515, Blast_Score=256, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=50.4918032786885, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=45.1505016722408, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=45.2380952380952, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=43.8127090301003, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=39.375, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=43.6619718309859, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=37.1069182389937, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=47.4137931034483, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71996324, Length=329, Percent_Identity=24.6200607902736, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=38.390092879257, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=38.9728096676737, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24643623, Length=317, Percent_Identity=38.1703470031546, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI20129101, Length=317, Percent_Identity=38.1703470031546, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32492; Mature: 32361

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIYENITELIGHTPIIKLQNVPADSADVYVKLEAFNPGGSVKDRIALSMIRAAEADGR
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
LQAGGTIVEPTSGNTGIGLAFVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASG
EECCCEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GMKAAIAKAKELSETEGYFLAMQFENPANPEVHEKTTGAEIIDAFGPTGLDAFVAGAGTG
CHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCHHEEECCCCC
GTITGVSHALKKVNPNIKTYVVEADESAILSGEPAGPHKIQGISAGFIPENLDTKSYDEI
CCHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCEECCEECCCCCCCCCCCCCCCE
IRVKGEDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLS
EEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
TALYDFDSEK
HHEECCCCCC
>Mature Secondary Structure 
TKIYENITELIGHTPIIKLQNVPADSADVYVKLEAFNPGGSVKDRIALSMIRAAEADGR
CHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
LQAGGTIVEPTSGNTGIGLAFVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASG
EECCCEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GMKAAIAKAKELSETEGYFLAMQFENPANPEVHEKTTGAEIIDAFGPTGLDAFVAGAGTG
CHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCHHEEECCCCC
GTITGVSHALKKVNPNIKTYVVEADESAILSGEPAGPHKIQGISAGFIPENLDTKSYDEI
CCHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCEECCEECCCCCCCCCCCCCCCE
IRVKGEDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLS
EEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
TALYDFDSEK
HHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA