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The map label for this gene is kinC [H]

Identifier: 125623280

GI number: 125623280

Start: 406813

End: 408240

Strand: Reverse

Name: kinC [H]

Synonym: llmg_0413

Alternate gene names: 125623280

Gene position: 408240-406813 (Counterclockwise)

Preceding gene: 125623281

Following gene: 125623279

Centisome position: 16.14

GC content: 34.03

Gene sequence:

>1428_bases
ATGATTAAATTTTTTAATTCAATGATTTTTAAAGGAGTAGTTGCCCACCTACTTCTTTTTGTCATTCTTTTCATGAGCAA
TTTCGATTATAATCTCATTCATCTTAGTACTTTTATTGGTTATTATTTATTTTCACTCGTTTTTGTTCTGGTTTTTCTCA
ATCAGCAACATCGAATGATTGTGAATGTTTCTAAACAAATGAACGATATAAAAAACGGTTATTTGAATAGAGATAAAATT
CCAAAAGGGACAAGTAAAATCAATGAATTATATGAAGAAATTTTGAAGCTTGGTGAGGACATTGTTAGGACTCAAAATAA
TCTTGAAAATCAACGCAATCAATTAGATAGCATTCTTGCCTACATGGTTGACGGAGTGATTGCCACAGATCGCCGTGGTA
ATATCATCATGGCTAATAAGTCAGCCCTCCATTACCTAAACACAAGTAATGAGCTTCTAATGGAAAAGAATATTGTTGAT
GTTTTGAAAATCGCAGACCAGTATAACTTTTATGATTTACTTGAAAAAGAACCTGAAATAACCATCGAAACACACGATGC
TGGGAATGAATCAATTTCACTCCACATCAAATTTGCACTCTTTCGTCGTGAGTCAGGGTTCATTTCAGGAATTATTGCTG
TCTTGCACGACATGACCAAACAAGATAAAGCAGAACGTGAACGTCGTCTTTTTGTTTCTAATGTCTCGCATGAATTAAGA
ACTCCACTTACTTCCGTCAAGGCCTATCTTGAAGCATTAGAAGATGGCGCAATTGATGATAAAGAAACAGCTTCTTCATT
CATCGGTGTTTCACTAACCGAAACCAATCGGATGATTCGGATGATTTCTGATCTTTTAACATTGTCAAGAATGGACCAAG
ATCGAATTGTTCTTAATAAAGAAATCATTAATTTAATTGCCTTTTTAGACTATCAAATTAATCGATTAGACCAGATTTTA
GAAACTGAATCAAATGATTTAATTTCATCCAATTTTACACTCGTTAGAAAGTATTCTGACAAGCCAATCTGGGTAGAAAT
TGATACCGATAAAATTGCCCAAGTCATTGATAATATCATTGGTAATGCCATTAAATATTCACCAAAAGGTGGTACAATTA
CAATTTACGTTGAAACTCGTGAACGAGATGTCTTAATTTCGATTAAAGACGAAGGAATGGGAATTCCAAAATCTGATTTA
CTTAAGATTTTTGACCGTTTCTATCGAGTAGATAATGCTTCAAGAAATTCAAAAGTAGGTGGAACAGGTTTAGGCTTATC
TATTGTCCATGACATTGTCAAAATACATGGCGGAACAATTTTTGCAAGCTCCGAAGGCGAAGGCAAAGGAACAACTTTCA
GTTTCACACTGCCATATTCTTCTGAAACTTCCGAATATTGGGATGACGCTGCTGATGATTTTGAATAA

Upstream 100 bases:

>100_bases
GTTACAGTCCGCCGCTTGCGTGAAAAAGTTGAAGATACACCAAGCCGTCCACAATACGTTTCAACACGCCGCGGGGTTGG
CTATTACATGAGCAACCCAC

Downstream 100 bases:

>100_bases
AATTGTCCTTCCTAATTCAAACTACAAAAAGAGTTCACTGTCAAATCCGTGAACTCTTTTTTGGGGAAAAAATCTATTAT
TTCTTACATAGACTTCTTCA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MIKFFNSMIFKGVVAHLLLFVILFMSNFDYNLIHLSTFIGYYLFSLVFVLVFLNQQHRMIVNVSKQMNDIKNGYLNRDKI
PKGTSKINELYEEILKLGEDIVRTQNNLENQRNQLDSILAYMVDGVIATDRRGNIIMANKSALHYLNTSNELLMEKNIVD
VLKIADQYNFYDLLEKEPEITIETHDAGNESISLHIKFALFRRESGFISGIIAVLHDMTKQDKAERERRLFVSNVSHELR
TPLTSVKAYLEALEDGAIDDKETASSFIGVSLTETNRMIRMISDLLTLSRMDQDRIVLNKEIINLIAFLDYQINRLDQIL
ETESNDLISSNFTLVRKYSDKPIWVEIDTDKIAQVIDNIIGNAIKYSPKGGTITIYVETRERDVLISIKDEGMGIPKSDL
LKIFDRFYRVDNASRNSKVGGTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSSETSEYWDDAADDFE

Sequences:

>Translated_475_residues
MIKFFNSMIFKGVVAHLLLFVILFMSNFDYNLIHLSTFIGYYLFSLVFVLVFLNQQHRMIVNVSKQMNDIKNGYLNRDKI
PKGTSKINELYEEILKLGEDIVRTQNNLENQRNQLDSILAYMVDGVIATDRRGNIIMANKSALHYLNTSNELLMEKNIVD
VLKIADQYNFYDLLEKEPEITIETHDAGNESISLHIKFALFRRESGFISGIIAVLHDMTKQDKAERERRLFVSNVSHELR
TPLTSVKAYLEALEDGAIDDKETASSFIGVSLTETNRMIRMISDLLTLSRMDQDRIVLNKEIINLIAFLDYQINRLDQIL
ETESNDLISSNFTLVRKYSDKPIWVEIDTDKIAQVIDNIIGNAIKYSPKGGTITIYVETRERDVLISIKDEGMGIPKSDL
LKIFDRFYRVDNASRNSKVGGTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSSETSEYWDDAADDFE
>Mature_475_residues
MIKFFNSMIFKGVVAHLLLFVILFMSNFDYNLIHLSTFIGYYLFSLVFVLVFLNQQHRMIVNVSKQMNDIKNGYLNRDKI
PKGTSKINELYEEILKLGEDIVRTQNNLENQRNQLDSILAYMVDGVIATDRRGNIIMANKSALHYLNTSNELLMEKNIVD
VLKIADQYNFYDLLEKEPEITIETHDAGNESISLHIKFALFRRESGFISGIIAVLHDMTKQDKAERERRLFVSNVSHELR
TPLTSVKAYLEALEDGAIDDKETASSFIGVSLTETNRMIRMISDLLTLSRMDQDRIVLNKEIINLIAFLDYQINRLDQIL
ETESNDLISSNFTLVRKYSDKPIWVEIDTDKIAQVIDNIIGNAIKYSPKGGTITIYVETRERDVLISIKDEGMGIPKSDL
LKIFDRFYRVDNASRNSKVGGTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSSETSEYWDDAADDFE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=32.5396825396825, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=31.5126050420168, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=31.5789473684211, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=29.1338582677165, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=31.2757201646091, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=30.2040816326531, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=31.9502074688797, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788549, Length=403, Percent_Identity=26.5508684863524, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=344, Percent_Identity=24.1279069767442, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=30.2788844621514, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=384, Percent_Identity=22.9166666666667, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=28.0334728033473, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=26.605504587156, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=27.1966527196653, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788279, Length=237, Percent_Identity=29.957805907173, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789403, Length=227, Percent_Identity=30.3964757709251, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082128, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=239, Percent_Identity=24.6861924686192, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54145; Mature: 54145

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKFFNSMIFKGVVAHLLLFVILFMSNFDYNLIHLSTFIGYYLFSLVFVLVFLNQQHRMI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VNVSKQMNDIKNGYLNRDKIPKGTSKINELYEEILKLGEDIVRTQNNLENQRNQLDSILA
EEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMVDGVIATDRRGNIIMANKSALHYLNTSNELLMEKNIVDVLKIADQYNFYDLLEKEPEI
HHHCCEEEECCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCE
TIETHDAGNESISLHIKFALFRRESGFISGIIAVLHDMTKQDKAERERRLFVSNVSHELR
EEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLTSVKAYLEALEDGAIDDKETASSFIGVSLTETNRMIRMISDLLTLSRMDQDRIVLNK
CCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EIINLIAFLDYQINRLDQILETESNDLISSNFTLVRKYSDKPIWVEIDTDKIAQVIDNII
HHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCEEEEECHHHHHHHHHHHH
GNAIKYSPKGGTITIYVETRERDVLISIKDEGMGIPKSDLLKIFDRFYRVDNASRNSKVG
CCCEEECCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSSETSEYWDDAADDFE
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MIKFFNSMIFKGVVAHLLLFVILFMSNFDYNLIHLSTFIGYYLFSLVFVLVFLNQQHRMI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VNVSKQMNDIKNGYLNRDKIPKGTSKINELYEEILKLGEDIVRTQNNLENQRNQLDSILA
EEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMVDGVIATDRRGNIIMANKSALHYLNTSNELLMEKNIVDVLKIADQYNFYDLLEKEPEI
HHHCCEEEECCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCE
TIETHDAGNESISLHIKFALFRRESGFISGIIAVLHDMTKQDKAERERRLFVSNVSHELR
EEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLTSVKAYLEALEDGAIDDKETASSFIGVSLTETNRMIRMISDLLTLSRMDQDRIVLNK
CCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EIINLIAFLDYQINRLDQILETESNDLISSNFTLVRKYSDKPIWVEIDTDKIAQVIDNII
HHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCEEEEECHHHHHHHHHHHH
GNAIKYSPKGGTITIYVETRERDVLISIKDEGMGIPKSDLLKIFDRFYRVDNASRNSKVG
CCCEEECCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GTGLGLSIVHDIVKIHGGTIFASSEGEGKGTTFSFTLPYSSETSEYWDDAADDFE
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]