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The map label for this gene is argG [H]

Identifier: 125623017

GI number: 125623017

Start: 134045

End: 135241

Strand: Direct

Name: argG [H]

Synonym: llmg_0138

Alternate gene names: 125623017

Gene position: 134045-135241 (Clockwise)

Preceding gene: 125623016

Following gene: 125623018

Centisome position: 5.3

GC content: 38.76

Gene sequence:

>1197_bases
ATGATGGGAAACAAAAAAATTGTCTTGGCATATTCAGGTGGATTGGATACGAGTGTCGCTGTAAAATGGCTGACTGATAA
AGGTTTTGATGTCATTGCCGCTTGCATGGATGTTGGTGAAGGGAAGGACTTGAATTTTATTCATGATAAAGCACTCCAAG
TTGGTGCGGTAGAGTCTGTTGTTCTAGACTGTAAGGCCGAATTCGCTGAAATCTTCGTTGGTGCTGCCCTCAAAGGAAAT
TTGATGTATGAAAATAAATATCCTTTAGTATCAGCATTGAGCCGCCCTTTAATTGCTAAAAAGTTAGTTAAGGTGGCTAA
AGAAAAAGGGGCAACCGCAATTGCTCATGGCTGTACAGGTAAAGGAAATGATCAAGTTCGTTTTGAAGTAGCAATCCATT
CACTTGCGCCAGAACTTGAAGTGATTGCTCCAGTCCGTGAGTGGCATTGGGCTCGTGAGGAAGAAATCGAGTATGCTAAT
CAAAATGGTGTTCCGATTCCTGCTGATTTGGATAATCCTTATTCTATTGATATGAATTTATGGGGACGTGCCATTGAAGC
AGGAGTTCTTGAAAATCCTTGGAATACCTGCCCTGAAGATGCTTTCTTCATGACTAATTCTGTTGAGGATGCTCCGAATG
AACCTGAGTTTATTGAAGTTGAGTTTAAAGAAGGTTTGCCAATTGCTTTGAATGGAAAAATCATGGAATTGCATGAAATT
ATTAAAGAAGTGAATATTATTGCAGGCAAACACGGTGTGGGTCGGATTGATCATATTGAAAACCGCTTGGTTGGGATTAA
ATCACGTGAATTTTATGAATGTCCAGCTGCTATTACCTTATTAAAAGCCCACAAGGATTTGGAAGATTTAACTTTTGTTC
GAGAATTAGCACATTTCAAGCCCGTTCTTGAAAATGAATTAGCAAATTTGATTTACAATGGCTTATGGTTTAATCCTGCG
ACTAAAGCTTTAATAGCTTATCTTGATGAAACACAAAAAGTAGTTAATGGCATCGTGAGAATTAAATTATACAAAGGTTT
AGCGACTCCAATAGGACGTAAGTCAACCAATTCTCTTTATAGTGAAAAATTGGCAACCTACACTGCAGCTGATGAGTTTG
ACCAGGCAGCGGCAGTTGGATTTATTAAACTTTGGGGCTTGCCTACTCAGGTTAATGCTCAAGTAAATCTCAAATAA

Upstream 100 bases:

>100_bases
TAAGAATAACTAAAACAAAAAACGCATATTTATACAAAAATGTTGACAAATGAATAAATATGCTGTATAATTGCATTTAT
ATTAATTTGAAAGAAGAAAA

Downstream 100 bases:

>100_bases
AAGATGAAAAAATTTGGAAAGTGAGAGAATGGTAGAAAAACTTTGGGGAGGACGTTTTGAAGCCTCATTAGATAAACAAA
CTGAAGAATTTGGTGCATCA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MMGNKKIVLAYSGGLDTSVAVKWLTDKGFDVIAACMDVGEGKDLNFIHDKALQVGAVESVVLDCKAEFAEIFVGAALKGN
LMYENKYPLVSALSRPLIAKKLVKVAKEKGATAIAHGCTGKGNDQVRFEVAIHSLAPELEVIAPVREWHWAREEEIEYAN
QNGVPIPADLDNPYSIDMNLWGRAIEAGVLENPWNTCPEDAFFMTNSVEDAPNEPEFIEVEFKEGLPIALNGKIMELHEI
IKEVNIIAGKHGVGRIDHIENRLVGIKSREFYECPAAITLLKAHKDLEDLTFVRELAHFKPVLENELANLIYNGLWFNPA
TKALIAYLDETQKVVNGIVRIKLYKGLATPIGRKSTNSLYSEKLATYTAADEFDQAAAVGFIKLWGLPTQVNAQVNLK

Sequences:

>Translated_398_residues
MMGNKKIVLAYSGGLDTSVAVKWLTDKGFDVIAACMDVGEGKDLNFIHDKALQVGAVESVVLDCKAEFAEIFVGAALKGN
LMYENKYPLVSALSRPLIAKKLVKVAKEKGATAIAHGCTGKGNDQVRFEVAIHSLAPELEVIAPVREWHWAREEEIEYAN
QNGVPIPADLDNPYSIDMNLWGRAIEAGVLENPWNTCPEDAFFMTNSVEDAPNEPEFIEVEFKEGLPIALNGKIMELHEI
IKEVNIIAGKHGVGRIDHIENRLVGIKSREFYECPAAITLLKAHKDLEDLTFVRELAHFKPVLENELANLIYNGLWFNPA
TKALIAYLDETQKVVNGIVRIKLYKGLATPIGRKSTNSLYSEKLATYTAADEFDQAAAVGFIKLWGLPTQVNAQVNLK
>Mature_398_residues
MMGNKKIVLAYSGGLDTSVAVKWLTDKGFDVIAACMDVGEGKDLNFIHDKALQVGAVESVVLDCKAEFAEIFVGAALKGN
LMYENKYPLVSALSRPLIAKKLVKVAKEKGATAIAHGCTGKGNDQVRFEVAIHSLAPELEVIAPVREWHWAREEEIEYAN
QNGVPIPADLDNPYSIDMNLWGRAIEAGVLENPWNTCPEDAFFMTNSVEDAPNEPEFIEVEFKEGLPIALNGKIMELHEI
IKEVNIIAGKHGVGRIDHIENRLVGIKSREFYECPAAITLLKAHKDLEDLTFVRELAHFKPVLENELANLIYNGLWFNPA
TKALIAYLDETQKVVNGIVRIKLYKGLATPIGRKSTNSLYSEKLATYTAADEFDQAAAVGFIKLWGLPTQVNAQVNLK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=397, Percent_Identity=41.3098236775819, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI16950633, Length=397, Percent_Identity=41.3098236775819, Blast_Score=301, Evalue=5e-82,
Organism=Escherichia coli, GI1789563, Length=373, Percent_Identity=31.0991957104558, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324514, Length=402, Percent_Identity=36.318407960199, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI21358151, Length=397, Percent_Identity=37.7833753148615, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 43959; Mature: 43959

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGNKKIVLAYSGGLDTSVAVKWLTDKGFDVIAACMDVGEGKDLNFIHDKALQVGAVESV
CCCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHH
VLDCKAEFAEIFVGAALKGNLMYENKYPLVSALSRPLIAKKLVKVAKEKGATAIAHGCTG
HHHHHHHHHHHHHHHEEECCEEECCCCCHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCC
KGNDQVRFEVAIHSLAPELEVIAPVREWHWAREEEIEYANQNGVPIPADLDNPYSIDMNL
CCCCEEEEEEEEEHHCCCHHEECCHHHHCCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHH
WGRAIEAGVLENPWNTCPEDAFFMTNSVEDAPNEPEFIEVEFKEGLPIALNGKIMELHEI
HHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEECCCHHHHHHH
IKEVNIIAGKHGVGRIDHIENRLVGIKSREFYECPAAITLLKAHKDLEDLTFVRELAHFK
HHHHHHEECCCCCCCHHHHHHHEECCCCCCHHHCHHHHHHHHHHCCHHHHHHHHHHHHHH
PVLENELANLIYNGLWFNPATKALIAYLDETQKVVNGIVRIKLYKGLATPIGRKSTNSLY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHH
SEKLATYTAADEFDQAAAVGFIKLWGLPTQVNAQVNLK
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECC
>Mature Secondary Structure
MMGNKKIVLAYSGGLDTSVAVKWLTDKGFDVIAACMDVGEGKDLNFIHDKALQVGAVESV
CCCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHH
VLDCKAEFAEIFVGAALKGNLMYENKYPLVSALSRPLIAKKLVKVAKEKGATAIAHGCTG
HHHHHHHHHHHHHHHEEECCEEECCCCCHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCC
KGNDQVRFEVAIHSLAPELEVIAPVREWHWAREEEIEYANQNGVPIPADLDNPYSIDMNL
CCCCEEEEEEEEEHHCCCHHEECCHHHHCCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHH
WGRAIEAGVLENPWNTCPEDAFFMTNSVEDAPNEPEFIEVEFKEGLPIALNGKIMELHEI
HHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEECCCHHHHHHH
IKEVNIIAGKHGVGRIDHIENRLVGIKSREFYECPAAITLLKAHKDLEDLTFVRELAHFK
HHHHHHEECCCCCCCHHHHHHHEECCCCCCHHHCHHHHHHHHHHCCHHHHHHHHHHHHHH
PVLENELANLIYNGLWFNPATKALIAYLDETQKVVNGIVRIKLYKGLATPIGRKSTNSLY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHH
SEKLATYTAADEFDQAAAVGFIKLWGLPTQVNAQVNLK
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]