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The map label for this gene is argH

Identifier: 125623018

GI number: 125623018

Start: 135270

End: 136649

Strand: Direct

Name: argH

Synonym: llmg_0139

Alternate gene names: 125623018

Gene position: 135270-136649 (Clockwise)

Preceding gene: 125623017

Following gene: 125623020

Centisome position: 5.35

GC content: 35.58

Gene sequence:

>1380_bases
ATGGTAGAAAAACTTTGGGGAGGACGTTTTGAAGCCTCATTAGATAAACAAACTGAAGAATTTGGTGCATCAATTAAATT
TGAACAAAGACTTGCTCCTTTTGATTTAAAGGGCTCTTTAGCTCATGTGAAAATGTTAGGTGAAACAGGGATTATCACTG
CTGAGGAAGCTACAACAATTGCTGATGGGCTGATAAAAGTAGAAGAAAAACTTATGAAGGGGCAAATTGAGTTCAAAATT
GAAAATGAAGACATTCATATGAATATGGAAACTTATCTTCATGATGAAATTGGTCCACTTGCAGGAAAACTTCATACCGC
TCGGTCTAGAAATGATCAAGTAGCAACCGATATGCACCTCTATCTCAAAAGTGTTTTATCTGATCTTTTAAAAGCTTTAA
GAACGCTTCGTGAAACTATTGTAAATCTTTCTGTAAACCATGTTGACACTCTTATGCCGGGTTATACTCATTTGCAACAT
GCCCAACCGATTTCTTTTGCCCAACATTTAATGGCCTATTATCAAATGTTTACTCGAGATTTTGAACGCTTTGAATTTAA
TGTAAAACATACTGATATGAATCCTTTAGGAGCGGCAGCTTTGGCTGGAACTACTTTTCCAATTGACAGGGAGTTAACCA
CAAATTTGCTTCAATTTGAGAAAGTCTATGCTAATTCCATGGATGCTGTCAGTGATCGTGATTTTATTTTGGAATTCTTG
TCAAACTCTAGTTTGTTGATGATGCATTTATCAAGATTATGTGAAGAACTTTTGCTTTGGTCTAGTCATGAATTCAATTT
TGTTAGTTTATCAGATAATTATTCTACGGGGTCCTCCATCATGCCACAAAAAAAGAATCCAGATATGGCTGAATTGATTC
GAGGAAAGAGCGGAAGAGTTTATGGAAATCTTATATCTTTATTGACTGTCATGAAGGGACTTCCTTTAACTTACAACAAA
GACTTACAAGAAGACAAAGAGGGAATGTTTGACAGTGCTGATACCATATTAACATCATTGAGTGTTATGGATGGAATGTT
GTCAACCATGACTGTAAACCGTGTAAACATGGAAAAGGCGACAGAGCAAGATTTTTCAAATGCAACCGAGCTGGCTGATT
ATCTTGCGGCAAAAGGTCTTCCTTTTAGGGAGGCACACGAATTAGTAGGTCAATTAGTTTTAAAATGCATAAAAAAAGGA
ATTTATCTTCAAGAGGTGAGCTTAAAAGACTATCAAGCTTTGTCTCAATTAATAGAAGAAGACGTTTATGAAATTTTGAA
ATCTAGAACGGCTGTTTCACGAAGGAATTCTTTAGGTGGAACTGGTTTTGAATCGATTAAGAAGCAAATTGAACAAGCAA
AAAAAGAGCTTCAAAAATGA

Upstream 100 bases:

>100_bases
GCAGCGGCAGTTGGATTTATTAAACTTTGGGGCTTGCCTACTCAGGTTAATGCTCAAGTAAATCTCAAATAAAAGATGAA
AAAATTTGGAAAGTGAGAGA

Downstream 100 bases:

>100_bases
AGCTCTTTTTATACAATTACTTTTTTAGTGTAACTGAATTATTGTGTGTAAAGTAGTTGATCAGATTGAAGATGACAAGG
ATTGCTGAACCTACAAATAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITAEEATTIADGLIKVEEKLMKGQIEFKI
ENEDIHMNMETYLHDEIGPLAGKLHTARSRNDQVATDMHLYLKSVLSDLLKALRTLRETIVNLSVNHVDTLMPGYTHLQH
AQPISFAQHLMAYYQMFTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRELTTNLLQFEKVYANSMDAVSDRDFILEFL
SNSSLLMMHLSRLCEELLLWSSHEFNFVSLSDNYSTGSSIMPQKKNPDMAELIRGKSGRVYGNLISLLTVMKGLPLTYNK
DLQEDKEGMFDSADTILTSLSVMDGMLSTMTVNRVNMEKATEQDFSNATELADYLAAKGLPFREAHELVGQLVLKCIKKG
IYLQEVSLKDYQALSQLIEEDVYEILKSRTAVSRRNSLGGTGFESIKKQIEQAKKELQK

Sequences:

>Translated_459_residues
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITAEEATTIADGLIKVEEKLMKGQIEFKI
ENEDIHMNMETYLHDEIGPLAGKLHTARSRNDQVATDMHLYLKSVLSDLLKALRTLRETIVNLSVNHVDTLMPGYTHLQH
AQPISFAQHLMAYYQMFTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRELTTNLLQFEKVYANSMDAVSDRDFILEFL
SNSSLLMMHLSRLCEELLLWSSHEFNFVSLSDNYSTGSSIMPQKKNPDMAELIRGKSGRVYGNLISLLTVMKGLPLTYNK
DLQEDKEGMFDSADTILTSLSVMDGMLSTMTVNRVNMEKATEQDFSNATELADYLAAKGLPFREAHELVGQLVLKCIKKG
IYLQEVSLKDYQALSQLIEEDVYEILKSRTAVSRRNSLGGTGFESIKKQIEQAKKELQK
>Mature_459_residues
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITAEEATTIADGLIKVEEKLMKGQIEFKI
ENEDIHMNMETYLHDEIGPLAGKLHTARSRNDQVATDMHLYLKSVLSDLLKALRTLRETIVNLSVNHVDTLMPGYTHLQH
AQPISFAQHLMAYYQMFTRDFERFEFNVKHTDMNPLGAAALAGTTFPIDRELTTNLLQFEKVYANSMDAVSDRDFILEFL
SNSSLLMMHLSRLCEELLLWSSHEFNFVSLSDNYSTGSSIMPQKKNPDMAELIRGKSGRVYGNLISLLTVMKGLPLTYNK
DLQEDKEGMFDSADTILTSLSVMDGMLSTMTVNRVNMEKATEQDFSNATELADYLAAKGLPFREAHELVGQLVLKCIKKG
IYLQEVSLKDYQALSQLIEEDVYEILKSRTAVSRRNSLGGTGFESIKKQIEQAKKELQK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=455, Percent_Identity=45.7142857142857, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=455, Percent_Identity=45.7142857142857, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303549, Length=455, Percent_Identity=43.7362637362637, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303547, Length=455, Percent_Identity=42.8571428571429, Blast_Score=357, Evalue=1e-98,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=46.2555066079295, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1787896, Length=342, Percent_Identity=24.2690058479532, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=41.6122004357298, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=39.1592920353982, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=39.1592920353982, Blast_Score=331, Evalue=7e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_LACLM (A2RHL0)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001031501.1
- ProteinModelPortal:   A2RHL0
- SMR:   A2RHL0
- STRING:   A2RHL0
- GeneID:   4796894
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_0139
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51867; Mature: 51867

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITAEEATTI
CCCCCCCCCCCCHHHHHHHHHCCCCEEHHCCCCCCCCCCHHHHEEECCCCCEECHHHHHH
ADGLIKVEEKLMKGQIEFKIENEDIHMNMETYLHDEIGPLAGKLHTARSRNDQVATDMHL
HHHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YLKSVLSDLLKALRTLRETIVNLSVNHVDTLMPGYTHLQHAQPISFAQHLMAYYQMFTRD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
FERFEFNVKHTDMNPLGAAALAGTTFPIDRELTTNLLQFEKVYANSMDAVSDRDFILEFL
HHHHEEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SNSSLLMMHLSRLCEELLLWSSHEFNFVSLSDNYSTGSSIMPQKKNPDMAELIRGKSGRV
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCH
YGNLISLLTVMKGLPLTYNKDLQEDKEGMFDSADTILTSLSVMDGMLSTMTVNRVNMEKA
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEQDFSNATELADYLAAKGLPFREAHELVGQLVLKCIKKGIYLQEVSLKDYQALSQLIEE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
DVYEILKSRTAVSRRNSLGGTGFESIKKQIEQAKKELQK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVEKLWGGRFEASLDKQTEEFGASIKFEQRLAPFDLKGSLAHVKMLGETGIITAEEATTI
CCCCCCCCCCCCHHHHHHHHHCCCCEEHHCCCCCCCCCCHHHHEEECCCCCEECHHHHHH
ADGLIKVEEKLMKGQIEFKIENEDIHMNMETYLHDEIGPLAGKLHTARSRNDQVATDMHL
HHHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YLKSVLSDLLKALRTLRETIVNLSVNHVDTLMPGYTHLQHAQPISFAQHLMAYYQMFTRD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
FERFEFNVKHTDMNPLGAAALAGTTFPIDRELTTNLLQFEKVYANSMDAVSDRDFILEFL
HHHHEEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SNSSLLMMHLSRLCEELLLWSSHEFNFVSLSDNYSTGSSIMPQKKNPDMAELIRGKSGRV
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCH
YGNLISLLTVMKGLPLTYNKDLQEDKEGMFDSADTILTSLSVMDGMLSTMTVNRVNMEKA
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEQDFSNATELADYLAAKGLPFREAHELVGQLVLKCIKKGIYLQEVSLKDYQALSQLIEE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
DVYEILKSRTAVSRRNSLGGTGFESIKKQIEQAKKELQK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA