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The map label for this gene is mtlA [H]

Identifier: 125622903

GI number: 125622903

Start: 26494

End: 28317

Strand: Direct

Name: mtlA [H]

Synonym: llmg_0022

Alternate gene names: 125622903

Gene position: 26494-28317 (Clockwise)

Preceding gene: 125622902

Following gene: 125622904

Centisome position: 1.05

GC content: 38.65

Gene sequence:

>1824_bases
ATGACTGATACTGTAAGCTTAAAAGTACGAGTTCAAAAACTTGGTACTGCATTATCTAATATGGTAATGCCCAATATTCC
TGTTTTAATTGCCTGGGGGGTGTTGACGATGTTCTTCATTCCTGATGGTTTTACACCTAATAAAACTTTTGCAGCGATGG
TTAGTCCCATGCTTCCTTTTCTTATTCCCTTAATGATTGGTTATACCGGTGGGAAAAATATTTATGAGCACCGTGGAGGA
GTAGTTGGTGCGATTGCAACCTTTGGTTCAATAATTGCGACAGCTAGTATTTCTGTAGGTGGTTTGAATGCTAAAGGAAA
TGTTCCGATGATTTTAGGAGCGATGATATTAGGACCTTTTGGCGCTTGGTTAATAAAAAAATTTGATGAATATATTCAAC
CACATATTAAAGCGGGCCTTGAAATGCTTATAAATAACTTTTCAGCAGGCTTAGTGGGATTTGGTTTATCTCTTTTTGCT
GTTAAAGTGGTTGGCCCACTTGTGGCTTGGCTAACAGATGTGATGGGACATGGCGTAGACTTTTTAATCTCTAACCATTT
AATTCCTCTTGCTAATCTTTTTATTGAGCCAGCAAAAATTTTATTTTTAAATAATGCAATCAATCAGGGAATCTTATCAC
CTTTAGGAATTCAACAGGTTTCTGAAAATGGGAAATCGCTTCTATTTTTATTGGAAGCTAATCCCGGTCCAGGGCTTGGA
ATTCTGATTGCCTTTATGCTTTTTGGTAAGGGTTCAGCTAAAGCAACAGCACCTGGTGCGATTTTAATTCAATTTGTTGG
TGGAATCCATGAAATTTACTTTCCTTATGTCATGATGAAACCTGCGCTCTTTTTTGCCGTCATGGCTGGCGGGGTGTCTG
GAACTTTAACAAATAACTTATTAGGTTCTGGTCTTGCAGCTCCTGCTTCACCTGGTTCGATTATTGCAATCACGGGAATG
GCATCTGGTAAATCAGCGGGTGGCTTTGCAAATGTTCTTTGCGTCTGGGCAGGGATTGCTGTAGCAGCAATTGTCTCTTT
TCTTGTAGCAGCCTTCATTTTAAAACGAGATAAATCGATGATTGATGATTCTGCTTTTGAAAATGCCAAAGTAGGAGTAG
CTACTGATAAGGCTGTCAGTAAGGGACAAGACTCTGTCAGCAATATTGTTACTGACCATGTCGATTTTTCTGCGATTAAA
CATATCATTTTTGCTTGTGATGCGGGAATGGGTTCATCGGCCATGGGTGCTTCTATTTTGAGAAATAAAGTCAAAAAAGC
TGGTTTGGGGCAAGATGTTACGAATGTCGCCATTGCTAACTTAAAAGCCGGTTCTGATACAATTGTCGTCACACAAGAGG
AACTTGCGCCAAGAGCTGCGACAATGGCTCCTGATGCTCATAGATATTCAGTGGCTAATTTCCTTAACTCACCTCGTTAC
GATGAAATTATCAGTAATCTAATGAATACTGATGAATCTGTCAGTGAACCTTTCATTGCTGACGACTTGGTCAGTAGAGA
AGAGATAGATTTGAATCAAATTGATGAAGTTGTTTTCTCTCATGATGGTTTACACATTGGTTCAAGTACTATGGGCAAAG
AAACCTTACAGGCAATTTTTAGCAGACATGATGTCAAGATTCCTATTTCTGATGTTGAATTTATTGGATTAGGCGCATTT
AATGCTAAAAACATCATGGTTGTTACAAAAGAAGAATTCACGGCAATAGCAAAACAGAAAGCTCCAAATGCTCAACATCT
TTCCGTTGAGTCTTTGATTACTACTCCAGAATACATCAATATGGTAAATCGAATGAACAAATAA

Upstream 100 bases:

>100_bases
TAAATCTTGGCACCTCCTTTTGTGTCAGGATTTTTATTTACAGTCTTATTGGTAGCGGTTATAATATAATTATATTAGTT
ACTATGTAAAGGAGTCTGAA

Downstream 100 bases:

>100_bases
AAAATCAATTGATTAGCTGATTAGTGAATAAGTAGAAATCAAAACAAAAAGGAATATTTATGTTTTTAACAAGTCGTGAG
CAAAAATTAATCCATACATT

Product: PTS system, mannitol-specific IIBC component

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTDTVSLKVRVQKLGTALSNMVMPNIPVLIAWGVLTMFFIPDGFTPNKTFAAMVSPMLPFLIPLMIGYTGGKNIYEHRGG
VVGAIATFGSIIATASISVGGLNAKGNVPMILGAMILGPFGAWLIKKFDEYIQPHIKAGLEMLINNFSAGLVGFGLSLFA
VKVVGPLVAWLTDVMGHGVDFLISNHLIPLANLFIEPAKILFLNNAINQGILSPLGIQQVSENGKSLLFLLEANPGPGLG
ILIAFMLFGKGSAKATAPGAILIQFVGGIHEIYFPYVMMKPALFFAVMAGGVSGTLTNNLLGSGLAAPASPGSIIAITGM
ASGKSAGGFANVLCVWAGIAVAAIVSFLVAAFILKRDKSMIDDSAFENAKVGVATDKAVSKGQDSVSNIVTDHVDFSAIK
HIIFACDAGMGSSAMGASILRNKVKKAGLGQDVTNVAIANLKAGSDTIVVTQEELAPRAATMAPDAHRYSVANFLNSPRY
DEIISNLMNTDESVSEPFIADDLVSREEIDLNQIDEVVFSHDGLHIGSSTMGKETLQAIFSRHDVKIPISDVEFIGLGAF
NAKNIMVVTKEEFTAIAKQKAPNAQHLSVESLITTPEYINMVNRMNK

Sequences:

>Translated_607_residues
MTDTVSLKVRVQKLGTALSNMVMPNIPVLIAWGVLTMFFIPDGFTPNKTFAAMVSPMLPFLIPLMIGYTGGKNIYEHRGG
VVGAIATFGSIIATASISVGGLNAKGNVPMILGAMILGPFGAWLIKKFDEYIQPHIKAGLEMLINNFSAGLVGFGLSLFA
VKVVGPLVAWLTDVMGHGVDFLISNHLIPLANLFIEPAKILFLNNAINQGILSPLGIQQVSENGKSLLFLLEANPGPGLG
ILIAFMLFGKGSAKATAPGAILIQFVGGIHEIYFPYVMMKPALFFAVMAGGVSGTLTNNLLGSGLAAPASPGSIIAITGM
ASGKSAGGFANVLCVWAGIAVAAIVSFLVAAFILKRDKSMIDDSAFENAKVGVATDKAVSKGQDSVSNIVTDHVDFSAIK
HIIFACDAGMGSSAMGASILRNKVKKAGLGQDVTNVAIANLKAGSDTIVVTQEELAPRAATMAPDAHRYSVANFLNSPRY
DEIISNLMNTDESVSEPFIADDLVSREEIDLNQIDEVVFSHDGLHIGSSTMGKETLQAIFSRHDVKIPISDVEFIGLGAF
NAKNIMVVTKEEFTAIAKQKAPNAQHLSVESLITTPEYINMVNRMNK
>Mature_606_residues
TDTVSLKVRVQKLGTALSNMVMPNIPVLIAWGVLTMFFIPDGFTPNKTFAAMVSPMLPFLIPLMIGYTGGKNIYEHRGGV
VGAIATFGSIIATASISVGGLNAKGNVPMILGAMILGPFGAWLIKKFDEYIQPHIKAGLEMLINNFSAGLVGFGLSLFAV
KVVGPLVAWLTDVMGHGVDFLISNHLIPLANLFIEPAKILFLNNAINQGILSPLGIQQVSENGKSLLFLLEANPGPGLGI
LIAFMLFGKGSAKATAPGAILIQFVGGIHEIYFPYVMMKPALFFAVMAGGVSGTLTNNLLGSGLAAPASPGSIIAITGMA
SGKSAGGFANVLCVWAGIAVAAIVSFLVAAFILKRDKSMIDDSAFENAKVGVATDKAVSKGQDSVSNIVTDHVDFSAIKH
IIFACDAGMGSSAMGASILRNKVKKAGLGQDVTNVAIANLKAGSDTIVVTQEELAPRAATMAPDAHRYSVANFLNSPRYD
EIISNLMNTDESVSEPFIADDLVSREEIDLNQIDEVVFSHDGLHIGSSTMGKETLQAIFSRHDVKIPISDVEFIGLGAFN
AKNIMVVTKEEFTAIAKQKAPNAQHLSVESLITTPEYINMVNRMNK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=531, Percent_Identity=47.2693032015066, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1789301, Length=485, Percent_Identity=43.0927835051546, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 64140; Mature: 64009

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTVSLKVRVQKLGTALSNMVMPNIPVLIAWGVLTMFFIPDGFTPNKTFAAMVSPMLPF
CCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LIPLMIGYTGGKNIYEHRGGVVGAIATFGSIIATASISVGGLNAKGNVPMILGAMILGPF
HHHHHHCCCCCCHHHHHCCCEEEHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHH
GAWLIKKFDEYIQPHIKAGLEMLINNFSAGLVGFGLSLFAVKVVGPLVAWLTDVMGHGVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLISNHLIPLANLFIEPAKILFLNNAINQGILSPLGIQQVSENGKSLLFLLEANPGPGLG
HHHHCCCHHHHHHHHCCHHEEEEHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCCCHH
ILIAFMLFGKGSAKATAPGAILIQFVGGIHEIYFPYVMMKPALFFAVMAGGVSGTLTNNL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LGSGLAAPASPGSIIAITGMASGKSAGGFANVLCVWAGIAVAAIVSFLVAAFILKRDKSM
HHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDDSAFENAKVGVATDKAVSKGQDSVSNIVTDHVDFSAIKHIIFACDAGMGSSAMGASIL
HCCHHHCCCCCCCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHH
RNKVKKAGLGQDVTNVAIANLKAGSDTIVVTQEELAPRAATMAPDAHRYSVANFLNSPRY
HHHHHHCCCCCCHHHHHHEEECCCCCEEEEEHHHHCCHHHHCCCCHHHHHHHHHHCCCCH
DEIISNLMNTDESVSEPFIADDLVSREEIDLNQIDEVVFSHDGLHIGSSTMGKETLQAIF
HHHHHHHHCCCCHHCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SRHDVKIPISDVEFIGLGAFNAKNIMVVTKEEFTAIAKQKAPNAQHLSVESLITTPEYIN
HCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEHHHHHCCHHHHH
MVNRMNK
HHHHCCC
>Mature Secondary Structure 
TDTVSLKVRVQKLGTALSNMVMPNIPVLIAWGVLTMFFIPDGFTPNKTFAAMVSPMLPF
CCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LIPLMIGYTGGKNIYEHRGGVVGAIATFGSIIATASISVGGLNAKGNVPMILGAMILGPF
HHHHHHCCCCCCHHHHHCCCEEEHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHH
GAWLIKKFDEYIQPHIKAGLEMLINNFSAGLVGFGLSLFAVKVVGPLVAWLTDVMGHGVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLISNHLIPLANLFIEPAKILFLNNAINQGILSPLGIQQVSENGKSLLFLLEANPGPGLG
HHHHCCCHHHHHHHHCCHHEEEEHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCCCHH
ILIAFMLFGKGSAKATAPGAILIQFVGGIHEIYFPYVMMKPALFFAVMAGGVSGTLTNNL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LGSGLAAPASPGSIIAITGMASGKSAGGFANVLCVWAGIAVAAIVSFLVAAFILKRDKSM
HHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDDSAFENAKVGVATDKAVSKGQDSVSNIVTDHVDFSAIKHIIFACDAGMGSSAMGASIL
HCCHHHCCCCCCCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHH
RNKVKKAGLGQDVTNVAIANLKAGSDTIVVTQEELAPRAATMAPDAHRYSVANFLNSPRY
HHHHHHCCCCCCHHHHHHEEECCCCCEEEEEHHHHCCHHHHCCCCHHHHHHHHHHCCCCH
DEIISNLMNTDESVSEPFIADDLVSREEIDLNQIDEVVFSHDGLHIGSSTMGKETLQAIF
HHHHHHHHCCCCHHCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SRHDVKIPISDVEFIGLGAFNAKNIMVVTKEEFTAIAKQKAPNAQHLSVESLITTPEYIN
HCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEHHHHHCCHHHHH
MVNRMNK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10878121; 12397186 [H]