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The map label for this gene is hpt [H]

Identifier: 125622901

GI number: 125622901

Start: 22583

End: 23134

Strand: Direct

Name: hpt [H]

Synonym: llmg_0020

Alternate gene names: 125622901

Gene position: 22583-23134 (Clockwise)

Preceding gene: 125622900

Following gene: 125622902

Centisome position: 0.89

GC content: 33.33

Gene sequence:

>552_bases
ATGCTCGAAAAAAATCTTGATAAGGCCATTGAAAAAGCACTAGTTTCAGAAGAAGAAATTATTGAAAAATCCAAAGAACT
TGGAGAAATATTAACAAAAGAATACGAAGGGAAAAATCCTTTAGTTTTAGGAATTCTTCGTGGGTCAGTTCCTTTCTTAG
CTGAACTAATCAAACATATTGATTGTCATCTTGAAACTGATTTTATGACCGTATCAAGCTATCACGGAGGAACAAAATCT
TCTGGTGAAGTAAAATTGATTTTAGACGTTGATACAGCGGTTAAAGGTCGTGAAATTTTGATTGTTGAAGATATTATCGA
CACAGGTCGCACTTTAAAATATCTAAAAGAACTTTTGGAACATCGTGGAGCAAATGTAAAAATTGTTACGCTTCTTGATA
AACCAGAAGGAAGAATTGTTGAAATTAAACCAGATTATTCAGGATTTACCATTCCAAATGAATTTGTTGTTGGCTTTGGT
TTAGACTACGAAGAAAACTACCGTAACCTCCCATATGTTGGGGTTTTGAAGCCTGAGGTTTATAGTAAATAA

Upstream 100 bases:

>100_bases
ATCGTCGGAGTCGCATGCTCTGATTTGAGTAAAGAGCTCAAAAATGATAAAATTAGAAGAATATTATGGGTCAAACCCAG
TATAGGAGAGGAAATCAACG

Downstream 100 bases:

>100_bases
TTCATTGATTTAAGTAGGTTAAAAATTTTCTCAGACTAAAGTATGAAAAAATCTCTGACCAATACTTACTATTAGCATTC
CAAAAGGAAATATGCTATAA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLEKNLDKAIEKALVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHIDCHLETDFMTVSSYHGGTKS
SGEVKLILDVDTAVKGREILIVEDIIDTGRTLKYLKELLEHRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFG
LDYEENYRNLPYVGVLKPEVYSK

Sequences:

>Translated_183_residues
MLEKNLDKAIEKALVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHIDCHLETDFMTVSSYHGGTKS
SGEVKLILDVDTAVKGREILIVEDIIDTGRTLKYLKELLEHRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFG
LDYEENYRNLPYVGVLKPEVYSK
>Mature_183_residues
MLEKNLDKAIEKALVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHIDCHLETDFMTVSSYHGGTKS
SGEVKLILDVDTAVKGREILIVEDIIDTGRTLKYLKELLEHRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFG
LDYEENYRNLPYVGVLKPEVYSK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=178, Percent_Identity=34.8314606741573, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI9910262, Length=179, Percent_Identity=33.5195530726257, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=43.3734939759036, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17510817, Length=181, Percent_Identity=30.3867403314917, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20607; Mature: 20607

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKNLDKAIEKALVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
DCHLETDFMTVSSYHGGTKSSGEVKLILDVDTAVKGREILIVEDIIDTGRTLKYLKELLE
HCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHHHH
HRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFGLDYEENYRNLPYVGVLKPEV
HCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEECCHH
YSK
CCC
>Mature Secondary Structure
MLEKNLDKAIEKALVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
DCHLETDFMTVSSYHGGTKSSGEVKLILDVDTAVKGREILIVEDIIDTGRTLKYLKELLE
HCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHHHH
HRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFGLDYEENYRNLPYVGVLKPEV
HCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEECCHH
YSK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1465108; 11337471 [H]