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The map label for this gene is 124486485

Identifier: 124486485

GI number: 124486485

Start: 1706191

End: 1707618

Strand: Reverse

Name: 124486485

Synonym: Mlab_1673

Alternate gene names: NA

Gene position: 1707618-1706191 (Counterclockwise)

Preceding gene: 124486488

Following gene: 124486484

Centisome position: 94.61

GC content: 57.28

Gene sequence:

>1428_bases
ATGCATGTTCTCTTTCCCACAGGACGCCAGAGTGCCCCCTCCCTCGTTCTGGCATTATCCAAGGTAACCGAGTTTACCTG
TGAGATCGTCGAAACAGGCGAAATTGCTTCTTTTTTAACGCCCGGATCATTAGAAAAGCTGATTCATGCGCACCCCTGCG
ATCTTGCGGTCGTTTCCGGGATGTGTACGGCGTCTTTTCGCGATACGGAAAAGAGAACGGGCGTTCCCATCAGGAAAGGA
ACGCGCCACGCGGCCGATATGGGGATGTGCGTTCCGCTGATATCGGCCGGCAGGCTTTCAGCGGATATGCCGGCCGACGA
TATGCTTGCCGAAGAGAAAAGAAAGGCCGCCCGGCAGAATCTGATCCTTGCCGAGTTCGAGGCCGAGCCGTTTTTTACGA
TCCGGGACGTGAAGATCGGGGGGACCTCGCGGATCAAGGTGATCCATGAGATCATGGACGCCCACCGGCACCCCTTCCTT
CGGGAAGCGGTGATTAGTGCCCATGAAAACGGGGCCGACATCGTGGATCTCGGGTTCGGGTTCGATGCGACCGAGGATGA
TGTGGTAAGGTGTTTTTCGATGGCGGCGGATCTGGACATCCCGCTTTCGATCGACACGCTGGATCCGATTCTGATCGAAG
CCGCGCTTTTCCGTGCGGATCTGATCCTTTCGCTTACGAAAGAAACGATCCCTCTTCTCGCAGAAAAGATCCTGGAGGCG
GGAGCGGCGGTTGTTTTGATCCCGCGGGACGATGCATCTCTCGAGGAGACGATCTCGTCGGCTCTGGATGCCGGACTTTT
CAAAATCCTCGCCGATCCGCTTCTCCAGCCGCCGCTTTCGGGGATGACCCGGTCCCTTGCCGGTTATCTGCCGGAGACAG
TTTGCCCGAAGGTGCTTGGATGCGTGAACGTCGTCGAGATGGTGGACGCGGACAGTCCGGGAATGTGCGCTATGCTTGCG
TCGGTCGCTGCCGAAACGGGGACCGCGTGCCTGTTGATTTCCGAACACTCGGACAAAACGCACGGGGCAACTGCCGAGAT
GCGGCGTGCGGTCGAGATGATGACGTTGTCGAAAGACCGCCCGTATCCAAAGGACGTCGGTCTCGATCTTTTGATCCTCA
AAGAAAAACGCTGCCGGCGGGAACCTCCCCTTCTCTACGAAGAGATCCGGGACGCCGGGGTTCCTTCGGACTCCCTCGAG
TATGATCCGAAAGGAAACTTCCGTATCGGGATCGAGAACGGATATATCGTCGCCGTCAGAGATGGAAAGGCGATCCGGGG
GACCTCGTGGTACGATGTCTTCTCTGAGATCCTCGCTGAAGACGGCGTTTCCCTGCTGGACCATGCAGCGTATCTCGGTA
AAGAGCTGTATAAAGCGGAGCTTGCCCTGCGGTTTGGCAGAAGTTTCGAGCAGGACGGGAACTTCTGA

Upstream 100 bases:

>100_bases
CCGTCCGCTGAAGCGCTCGTGTGGATATGCAGATCGCAGGTAATGAGAACCATCTTACGGTAATTACTATGTAAGTACAA
AAACATAAGGATAACATACA

Downstream 100 bases:

>100_bases
CCATGCGGTATTATCTGCGAAAGGATGTTTTGATCGTCAGAGGAAACTTTCGGGCGGCAAGCAACGGTGTGGACGGCGGC
CTTGCGGACGTCAGATCGAT

Product: hypothetical protein

Products: diphosphate; dihydropteroate

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MHVLFPTGRQSAPSLVLALSKVTEFTCEIVETGEIASFLTPGSLEKLIHAHPCDLAVVSGMCTASFRDTEKRTGVPIRKG
TRHAADMGMCVPLISAGRLSADMPADDMLAEEKRKAARQNLILAEFEAEPFFTIRDVKIGGTSRIKVIHEIMDAHRHPFL
REAVISAHENGADIVDLGFGFDATEDDVVRCFSMAADLDIPLSIDTLDPILIEAALFRADLILSLTKETIPLLAEKILEA
GAAVVLIPRDDASLEETISSALDAGLFKILADPLLQPPLSGMTRSLAGYLPETVCPKVLGCVNVVEMVDADSPGMCAMLA
SVAAETGTACLLISEHSDKTHGATAEMRRAVEMMTLSKDRPYPKDVGLDLLILKEKRCRREPPLLYEEIRDAGVPSDSLE
YDPKGNFRIGIENGYIVAVRDGKAIRGTSWYDVFSEILAEDGVSLLDHAAYLGKELYKAELALRFGRSFEQDGNF

Sequences:

>Translated_475_residues
MHVLFPTGRQSAPSLVLALSKVTEFTCEIVETGEIASFLTPGSLEKLIHAHPCDLAVVSGMCTASFRDTEKRTGVPIRKG
TRHAADMGMCVPLISAGRLSADMPADDMLAEEKRKAARQNLILAEFEAEPFFTIRDVKIGGTSRIKVIHEIMDAHRHPFL
REAVISAHENGADIVDLGFGFDATEDDVVRCFSMAADLDIPLSIDTLDPILIEAALFRADLILSLTKETIPLLAEKILEA
GAAVVLIPRDDASLEETISSALDAGLFKILADPLLQPPLSGMTRSLAGYLPETVCPKVLGCVNVVEMVDADSPGMCAMLA
SVAAETGTACLLISEHSDKTHGATAEMRRAVEMMTLSKDRPYPKDVGLDLLILKEKRCRREPPLLYEEIRDAGVPSDSLE
YDPKGNFRIGIENGYIVAVRDGKAIRGTSWYDVFSEILAEDGVSLLDHAAYLGKELYKAELALRFGRSFEQDGNF
>Mature_475_residues
MHVLFPTGRQSAPSLVLALSKVTEFTCEIVETGEIASFLTPGSLEKLIHAHPCDLAVVSGMCTASFRDTEKRTGVPIRKG
TRHAADMGMCVPLISAGRLSADMPADDMLAEEKRKAARQNLILAEFEAEPFFTIRDVKIGGTSRIKVIHEIMDAHRHPFL
REAVISAHENGADIVDLGFGFDATEDDVVRCFSMAADLDIPLSIDTLDPILIEAALFRADLILSLTKETIPLLAEKILEA
GAAVVLIPRDDASLEETISSALDAGLFKILADPLLQPPLSGMTRSLAGYLPETVCPKVLGCVNVVEMVDADSPGMCAMLA
SVAAETGTACLLISEHSDKTHGATAEMRRAVEMMTLSKDRPYPKDVGLDLLILKEKRCRREPPLLYEEIRDAGVPSDSLE
YDPKGNFRIGIENGYIVAVRDGKAIRGTSWYDVFSEILAEDGVSLLDHAAYLGKELYKAELALRFGRSFEQDGNF

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: 2.5.1.15

Molecular weight: Translated: 51673; Mature: 51673

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLFPTGRQSAPSLVLALSKVTEFTCEIVETGEIASFLTPGSLEKLIHAHPCDLAVVSG
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCCHHHHHH
MCTASFRDTEKRTGVPIRKGTRHAADMGMCVPLISAGRLSADMPADDMLAEEKRKAARQN
HHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
LILAEFEAEPFFTIRDVKIGGTSRIKVIHEIMDAHRHPFLREAVISAHENGADIVDLGFG
CEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCC
FDATEDDVVRCFSMAADLDIPLSIDTLDPILIEAALFRADLILSLTKETIPLLAEKILEA
CCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAAVVLIPRDDASLEETISSALDAGLFKILADPLLQPPLSGMTRSLAGYLPETVCPKVLG
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHH
CVNVVEMVDADSPGMCAMLASVAAETGTACLLISEHSDKTHGATAEMRRAVEMMTLSKDR
HHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
PYPKDVGLDLLILKEKRCRREPPLLYEEIRDAGVPSDSLEYDPKGNFRIGIENGYIVAVR
CCCHHCCCEEEEECCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEEE
DGKAIRGTSWYDVFSEILAEDGVSLLDHAAYLGKELYKAELALRFGRSFEQDGNF
CCCEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHVLFPTGRQSAPSLVLALSKVTEFTCEIVETGEIASFLTPGSLEKLIHAHPCDLAVVSG
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCCHHHHHH
MCTASFRDTEKRTGVPIRKGTRHAADMGMCVPLISAGRLSADMPADDMLAEEKRKAARQN
HHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
LILAEFEAEPFFTIRDVKIGGTSRIKVIHEIMDAHRHPFLREAVISAHENGADIVDLGFG
CEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCC
FDATEDDVVRCFSMAADLDIPLSIDTLDPILIEAALFRADLILSLTKETIPLLAEKILEA
CCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAAVVLIPRDDASLEETISSALDAGLFKILADPLLQPPLSGMTRSLAGYLPETVCPKVLG
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHH
CVNVVEMVDADSPGMCAMLASVAAETGTACLLISEHSDKTHGATAEMRRAVEMMTLSKDR
HHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
PYPKDVGLDLLILKEKRCRREPPLLYEEIRDAGVPSDSLEYDPKGNFRIGIENGYIVAVR
CCCHHCCCEEEEECCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEEE
DGKAIRGTSWYDVFSEILAEDGVSLLDHAAYLGKELYKAELALRFGRSFEQDGNF
CCCEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate; 4-aminobenzoate

Specific reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]