Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 124486475

GI number: 124486475

Start: 1697288

End: 1698115

Strand: Reverse

Name: nadC [H]

Synonym: Mlab_1663

Alternate gene names: 124486475

Gene position: 1698115-1697288 (Counterclockwise)

Preceding gene: 124486476

Following gene: 124486474

Centisome position: 94.08

GC content: 56.04

Gene sequence:

>828_bases
ATGATCCCGACCGACCAGCTTCTCTCGTTCGTTGCCGAGGACGTTTCCGCAGGCGATATCACGACCCTTGCCCTTCTGGA
AGACAATGTGGTCTCGGCCCATATCGAGGCACGTGAAGAGATGGTCGTATCCGGCATAGAAGAGTGCGAATGGCTGTTTA
AAAACGCCGGGGTTTTTACCGAGGTCCTGGTCAAAGACGGTTCGACGGCCCATGCGGGCGAGAAGATCCTCGACCTCAAA
GGCTCGGTCCATGCGATCCTCTCTCTCGAGCGGACGTGTCTCAATCTTCTGGGTAGAATGAGCGGCATCGCATCTTCTGC
GGCGAAGGCGTCCCGTCTCGTTTCGGTCGTGAATGATCATGTCAGGGTCGCCGGAACGAGGAAGACGGCTCCCGGCCTCC
GCTTTTTCGATAAAAAAGCCCTGATCGCCGGCGGTGCTCTTCCTCACCGATACACGCTTTCGGATCAGTTTCTCATCAAG
GATACCCATCGGACGATGATGCCGGTCGATGAGGCGATACGCAAATGCCGGGAATATTCCGATAAAAAGGTGGAGTGCGA
GGTCGAGTCTTTAGAGGATGCTCTTCTTGCGGCAAAGACCGGCGCCGACATCATCATGTTCGACAACATGACTCCGGAAC
TTATCCGCGAAGCGATCGCCGCTCTCGAGGAAGCAGGCCTTCGCGGGGAAGTGACTTTGGAGATCTCGGGCGGCATCACG
CCGGAGACCGTCGATAAATACGCCGGTCTCGATGTGGATGTGATCAGTATGGGGGCGCTGACCCATTCGGTCCGCTGTGC
GGATGTGAGTTTAGAGGTTGATATATAA

Upstream 100 bases:

>100_bases
CATCACGCTTAGGGACGGCGTCGTTCCGATCCAGGTGCCGGAAAGCATCGCGGACCGGGCCCGCCTTGCGATCGAGCGGA
TGATCGGGGCATCGGCATAA

Downstream 100 bases:

>100_bases
ATGCAGGTTGAGACGAAAGCAGCTCTCGCTCTTTTCGCCGGATCGATCCTGCTGACTGTCGTGTTTTTCCTTCTGGGATT
GCCGTTCTTCTTCCTGTTCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MIPTDQLLSFVAEDVSAGDITTLALLEDNVVSAHIEAREEMVVSGIEECEWLFKNAGVFTEVLVKDGSTAHAGEKILDLK
GSVHAILSLERTCLNLLGRMSGIASSAAKASRLVSVVNDHVRVAGTRKTAPGLRFFDKKALIAGGALPHRYTLSDQFLIK
DTHRTMMPVDEAIRKCREYSDKKVECEVESLEDALLAAKTGADIIMFDNMTPELIREAIAALEEAGLRGEVTLEISGGIT
PETVDKYAGLDVDVISMGALTHSVRCADVSLEVDI

Sequences:

>Translated_275_residues
MIPTDQLLSFVAEDVSAGDITTLALLEDNVVSAHIEAREEMVVSGIEECEWLFKNAGVFTEVLVKDGSTAHAGEKILDLK
GSVHAILSLERTCLNLLGRMSGIASSAAKASRLVSVVNDHVRVAGTRKTAPGLRFFDKKALIAGGALPHRYTLSDQFLIK
DTHRTMMPVDEAIRKCREYSDKKVECEVESLEDALLAAKTGADIIMFDNMTPELIREAIAALEEAGLRGEVTLEISGGIT
PETVDKYAGLDVDVISMGALTHSVRCADVSLEVDI
>Mature_275_residues
MIPTDQLLSFVAEDVSAGDITTLALLEDNVVSAHIEAREEMVVSGIEECEWLFKNAGVFTEVLVKDGSTAHAGEKILDLK
GSVHAILSLERTCLNLLGRMSGIASSAAKASRLVSVVNDHVRVAGTRKTAPGLRFFDKKALIAGGALPHRYTLSDQFLIK
DTHRTMMPVDEAIRKCREYSDKKVECEVESLEDALLAAKTGADIIMFDNMTPELIREAIAALEEAGLRGEVTLEISGGIT
PETVDKYAGLDVDVISMGALTHSVRCADVSLEVDI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=245, Percent_Identity=35.5102040816327, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786299, Length=258, Percent_Identity=37.984496124031, Blast_Score=118, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321162, Length=275, Percent_Identity=28.7272727272727, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29669; Mature: 29669

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTDQLLSFVAEDVSAGDITTLALLEDNVVSAHIEAREEMVVSGIEECEWLFKNAGVFT
CCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHE
EVLVKDGSTAHAGEKILDLKGSVHAILSLERTCLNLLGRMSGIASSAAKASRLVSVVNDH
EHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VRVAGTRKTAPGLRFFDKKALIAGGALPHRYTLSDQFLIKDTHRTMMPVDEAIRKCREYS
EEEEECCCCCCCCHHHCCHHHEECCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHCC
DKKVECEVESLEDALLAAKTGADIIMFDNMTPELIREAIAALEEAGLRGEVTLEISGGIT
CCEEEEHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
PETVDKYAGLDVDVISMGALTHSVRCADVSLEVDI
HHHHHHHCCCCEEHEEHHHHHHEEEEEEEEEEECC
>Mature Secondary Structure
MIPTDQLLSFVAEDVSAGDITTLALLEDNVVSAHIEAREEMVVSGIEECEWLFKNAGVFT
CCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHE
EVLVKDGSTAHAGEKILDLKGSVHAILSLERTCLNLLGRMSGIASSAAKASRLVSVVNDH
EHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VRVAGTRKTAPGLRFFDKKALIAGGALPHRYTLSDQFLIKDTHRTMMPVDEAIRKCREYS
EEEEECCCCCCCCHHHCCHHHEECCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHCC
DKKVECEVESLEDALLAAKTGADIIMFDNMTPELIREAIAALEEAGLRGEVTLEISGGIT
CCEEEEHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
PETVDKYAGLDVDVISMGALTHSVRCADVSLEVDI
HHHHHHHCCCCEEHEEHHHHHHEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]