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The map label for this gene is aroE [H]

Identifier: 124486464

GI number: 124486464

Start: 1680104

End: 1681525

Strand: Reverse

Name: aroE [H]

Synonym: Mlab_1652

Alternate gene names: 124486464

Gene position: 1681525-1680104 (Counterclockwise)

Preceding gene: 124486465

Following gene: 124486463

Centisome position: 93.16

GC content: 52.39

Gene sequence:

>1422_bases
ATGACTGCAAATTGTGCCGTTATCGTGGCGAAAGATGAGAGAGAAGTTCGAACTCTTTCAGAAGAAGCGATCTCGAAAGG
AGCAGAGGCTCTTGAATTCCGGCTGGATTCCTTCCCGGTTATTCCTGCAGACCTCTCCTTTCTTTCATGCGGGGTTCCAT
CAATAGCCACACTCAGATCTCCGTTGGACGAAGAGCGGAAGGAGATTTTCATCCGTGCTCTTTCGTCGGGCGCGACATAC
ATCGACATAGAATCAGATTCGGTTCTGAGAGGTCAGTTTCCAAAAGAACAGGTCATCTGTTCGTATCATGACTTTGAAAA
AACTCCTGCCGATGATGAAATTCTCACGATCTTCAAAGACCTCCAATCTTCGGGAATCCCCAAAGCCGCATTCATGGTGA
GGGGGCCGGCGGATCTGCTTGCCGTCTGGAATGCAGCATCAGTTCTGAGAGAAAGAGGATATCCGTTTATCTTTATAGGC
ATGGGGGCCGCCGGTGAGGTTACACGTATCCGTGCCGCCGAGCTTGGATCAATGCTCAACTACTGTGCCTTAAGGCCGGA
ACTTGCATCCGCTCCGGGTCAGATAACACTGGAAGAGGCTGAGAGACTCGGTACCGACCCGCAGATTACTGCCGTAACCG
GATATCCTTTGACCCATACCTTCTCGCCGGAGATCCACAACGCAGCGTTCAAAGCCGCGAAGATCCGGGGAAGATATGTG
AAGATCCCCGCAGCTTCTCAGGAAGTGCCCCTGATTCCTGATGTTATCAAAAAATATCGGATCATCGGGATGAACGTAAC
CATTCCTCATAAAGAGTCGGTCATCCCTCTCCTGAAACGGATAGATCCTCTCGCGGAGTCTGCCGGCGCAGTGAACACTA
TCCGAAATTCTCCCGCCGGCCTTGAGGGGTACAATACCGATATTCTGGGAATAGCGGCGTCGCTCGCTTCGGTGGATATG
GATCCAAAGGATGCCGATGTGCTTATCATCGGTGCCGGAGGGGCAGCAAAGGCCGCCGCCGCATATCTGAAATCTGCCGG
TGCTCGTCTTTCGATAACCAACAGGACCCATTCCCGGGCAGAGACACTTGCCGAAATATTTGGTGCCCGGGCAGTGAAGC
TGGAGGACCTTGCTCCGGAGTATCAGCTGATTCTGAATGCGACCCCGGCTGGAATGAGCGGGTTTGAACACTGCTCACCG
GTTCCAAATACGCTATTCACCAAAGACACGGTTGTTATGGATATGATCTATGATCCGGAAGTGACTCCCCTTCTTGCCGC
TGCAAAAGCAGCCGGCGTTCGTGCCTGCATCAACGGAAAGACCATGCTTATCGAACAGGCCGCCGCGTCATTCACTCTCT
GGACAGGAATTACTCCGAATCGTGATGTGATGAGAAAAGCATTCGAAGCGAGGGCGGCATGA

Upstream 100 bases:

>100_bases
TTTCCGTATCCGATCTCGCGATCGGCGATCTGGTCTACGTCAGACTTGAAAGCGGCGGCCGCCACTTCGGGCATACGATG
GCGGAAACAATCTGCGAAAA

Downstream 100 bases:

>100_bases
TCGGTAAAGGCATGTCCTACGGTGCTTTGTCGGTGATCAATGCGGTATCTACCGGAAAAGGGGCAGCATTCGGCATAGAC
CTCAAAACCGAGGCGACCGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTANCAVIVAKDEREVRTLSEEAISKGAEALEFRLDSFPVIPADLSFLSCGVPSIATLRSPLDEERKEIFIRALSSGATY
IDIESDSVLRGQFPKEQVICSYHDFEKTPADDEILTIFKDLQSSGIPKAAFMVRGPADLLAVWNAASVLRERGYPFIFIG
MGAAGEVTRIRAAELGSMLNYCALRPELASAPGQITLEEAERLGTDPQITAVTGYPLTHTFSPEIHNAAFKAAKIRGRYV
KIPAASQEVPLIPDVIKKYRIIGMNVTIPHKESVIPLLKRIDPLAESAGAVNTIRNSPAGLEGYNTDILGIAASLASVDM
DPKDADVLIIGAGGAAKAAAAYLKSAGARLSITNRTHSRAETLAEIFGARAVKLEDLAPEYQLILNATPAGMSGFEHCSP
VPNTLFTKDTVVMDMIYDPEVTPLLAAAKAAGVRACINGKTMLIEQAAASFTLWTGITPNRDVMRKAFEARAA

Sequences:

>Translated_473_residues
MTANCAVIVAKDEREVRTLSEEAISKGAEALEFRLDSFPVIPADLSFLSCGVPSIATLRSPLDEERKEIFIRALSSGATY
IDIESDSVLRGQFPKEQVICSYHDFEKTPADDEILTIFKDLQSSGIPKAAFMVRGPADLLAVWNAASVLRERGYPFIFIG
MGAAGEVTRIRAAELGSMLNYCALRPELASAPGQITLEEAERLGTDPQITAVTGYPLTHTFSPEIHNAAFKAAKIRGRYV
KIPAASQEVPLIPDVIKKYRIIGMNVTIPHKESVIPLLKRIDPLAESAGAVNTIRNSPAGLEGYNTDILGIAASLASVDM
DPKDADVLIIGAGGAAKAAAAYLKSAGARLSITNRTHSRAETLAEIFGARAVKLEDLAPEYQLILNATPAGMSGFEHCSP
VPNTLFTKDTVVMDMIYDPEVTPLLAAAKAAGVRACINGKTMLIEQAAASFTLWTGITPNRDVMRKAFEARAA
>Mature_472_residues
TANCAVIVAKDEREVRTLSEEAISKGAEALEFRLDSFPVIPADLSFLSCGVPSIATLRSPLDEERKEIFIRALSSGATYI
DIESDSVLRGQFPKEQVICSYHDFEKTPADDEILTIFKDLQSSGIPKAAFMVRGPADLLAVWNAASVLRERGYPFIFIGM
GAAGEVTRIRAAELGSMLNYCALRPELASAPGQITLEEAERLGTDPQITAVTGYPLTHTFSPEIHNAAFKAAKIRGRYVK
IPAASQEVPLIPDVIKKYRIIGMNVTIPHKESVIPLLKRIDPLAESAGAVNTIRNSPAGLEGYNTDILGIAASLASVDMD
PKDADVLIIGAGGAAKAAAAYLKSAGARLSITNRTHSRAETLAEIFGARAVKLEDLAPEYQLILNATPAGMSGFEHCSPV
PNTLFTKDTVVMDMIYDPEVTPLLAAAKAAGVRACINGKTMLIEQAAASFTLWTGITPNRDVMRKAFEARAA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=265, Percent_Identity=33.2075471698113, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1787983, Length=267, Percent_Identity=29.5880149812734, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320332, Length=513, Percent_Identity=25.9259259259259, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 50746; Mature: 50615

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANCAVIVAKDEREVRTLSEEAISKGAEALEFRLDSFPVIPADLSFLSCGVPSIATLRS
CCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHC
PLDEERKEIFIRALSSGATYIDIESDSVLRGQFPKEQVICSYHDFEKTPADDEILTIFKD
CHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHEEEEECCCCCCCCCHHHHHHHHH
LQSSGIPKAAFMVRGPADLLAVWNAASVLRERGYPFIFIGMGAAGEVTRIRAAELGSMLN
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH
YCALRPELASAPGQITLEEAERLGTDPQITAVTGYPLTHTFSPEIHNAAFKAAKIRGRYV
HHHCCCHHHCCCCCEEHHHHHHCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHCCCEE
KIPAASQEVPLIPDVIKKYRIIGMNVTIPHKESVIPLLKRIDPLAESAGAVNTIRNSPAG
ECCCCCCCCCCCHHHHHCEEEEEEEEECCCCHHHHHHHHHHCHHHHHCCCHHHHCCCCCC
LEGYNTDILGIAASLASVDMDPKDADVLIIGAGGAAKAAAAYLKSAGARLSITNRTHSRA
CCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHH
ETLAEIFGARAVKLEDLAPEYQLILNATPAGMSGFEHCSPVPNTLFTKDTVVMDMIYDPE
HHHHHHHCCCEEEHHHCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCCEEEEEEEECCC
VTPLLAAAKAAGVRACINGKTMLIEQAAASFTLWTGITPNRDVMRKAFEARAA
CCHHHHHHHHCCCEEEECCCEEEEEHHCCCEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TANCAVIVAKDEREVRTLSEEAISKGAEALEFRLDSFPVIPADLSFLSCGVPSIATLRS
CCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHC
PLDEERKEIFIRALSSGATYIDIESDSVLRGQFPKEQVICSYHDFEKTPADDEILTIFKD
CHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHEEEEECCCCCCCCCHHHHHHHHH
LQSSGIPKAAFMVRGPADLLAVWNAASVLRERGYPFIFIGMGAAGEVTRIRAAELGSMLN
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH
YCALRPELASAPGQITLEEAERLGTDPQITAVTGYPLTHTFSPEIHNAAFKAAKIRGRYV
HHHCCCHHHCCCCCEEHHHHHHCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHCCCEE
KIPAASQEVPLIPDVIKKYRIIGMNVTIPHKESVIPLLKRIDPLAESAGAVNTIRNSPAG
ECCCCCCCCCCCHHHHHCEEEEEEEEECCCCHHHHHHHHHHCHHHHHCCCHHHHCCCCCC
LEGYNTDILGIAASLASVDMDPKDADVLIIGAGGAAKAAAAYLKSAGARLSITNRTHSRA
CCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHH
ETLAEIFGARAVKLEDLAPEYQLILNATPAGMSGFEHCSPVPNTLFTKDTVVMDMIYDPE
HHHHHHHCCCEEEHHHCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCCEEEEEEEECCC
VTPLLAAAKAAGVRACINGKTMLIEQAAASFTLWTGITPNRDVMRKAFEARAA
CCHHHHHHHHCCCEEEECCCEEEEEHHCCCEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA