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The map label for this gene is eif6

Identifier: 124486294

GI number: 124486294

Start: 1517369

End: 1518037

Strand: Reverse

Name: eif6

Synonym: Mlab_1478

Alternate gene names: 124486294

Gene position: 1518037-1517369 (Counterclockwise)

Preceding gene: 124486295

Following gene: 124486293

Centisome position: 84.1

GC content: 50.52

Gene sequence:

>669_bases
ATGGACCCGACCCTGTCATTGAATGGTGACCCGAACATCGGCGTGTATGCCCGTGTCTTTGAAGATCTTGCCGTAGTCCC
GGTCGAAGCTCCAAAAGAGTTCCGGGACAAAATAGCGGAAGCTTTGGATGTCGAGGTTATTGAAACCTTTGTCCAGGGAT
CCTCTGTCATAGGTCTTCTTCTGACAGGCAACTCCCGCGGATTTGTCGTTTCCGGTCTCATTCAGGATTCAGAACTCGAA
ATCCTTCAGGAGTACGGCGACTGTCTGCTCCTTGGAGAAGAGATGAATGCGGCAGGGAACGTAATCCTGACCAACGATTC
GTTTGCCGTCGTGCATCCGGACATGTCGTCTGCGATGCGCGAAATGGTGGCGGATTTTCTGAAAGTCAAGATAATCCCGA
TGTCCTTTGCAGGAGTCGGAACGGTCGGTATGACATGCGCCTGTACAAATACAGGTGTTCTTCTACCGGCACGAAGTACT
CCCGAGGAGATCGAAAAACTGGAACGCAGCATCGATGATGCTAACGTGGCTATCGGAACCGGATCCGTCAACATGGGTTC
GGGACTTATAGGTACCGGTCTTCTGATCAACAGTAAAGGATATCTGGCAGGTAACGCTACCACGGGCTATGAACTTGGTA
GAATCGAAGATGTATTTGGATTCTTGTGA

Upstream 100 bases:

>100_bases
CGTCTGGGCACGCGGATCCCAGAAACCGCCAAGACGCATTCGTGTTCGGGCAATGAAGTTCGAAGATGGTCAGGTCCAGG
CAGAACTTGCTGAGGAATAA

Downstream 100 bases:

>100_bases
AAAATTTCTATTTTTCACGAGTTGAGCATGCTTTGTAAAAAGTATGCGATTTCTGTGAGGTGAAATGAATGCCGAAATTC
GAGGTAAAGGGCACGTTCAA

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MDPTLSLNGDPNIGVYARVFEDLAVVPVEAPKEFRDKIAEALDVEVIETFVQGSSVIGLLLTGNSRGFVVSGLIQDSELE
ILQEYGDCLLLGEEMNAAGNVILTNDSFAVVHPDMSSAMREMVADFLKVKIIPMSFAGVGTVGMTCACTNTGVLLPARST
PEEIEKLERSIDDANVAIGTGSVNMGSGLIGTGLLINSKGYLAGNATTGYELGRIEDVFGFL

Sequences:

>Translated_222_residues
MDPTLSLNGDPNIGVYARVFEDLAVVPVEAPKEFRDKIAEALDVEVIETFVQGSSVIGLLLTGNSRGFVVSGLIQDSELE
ILQEYGDCLLLGEEMNAAGNVILTNDSFAVVHPDMSSAMREMVADFLKVKIIPMSFAGVGTVGMTCACTNTGVLLPARST
PEEIEKLERSIDDANVAIGTGSVNMGSGLIGTGLLINSKGYLAGNATTGYELGRIEDVFGFL
>Mature_222_residues
MDPTLSLNGDPNIGVYARVFEDLAVVPVEAPKEFRDKIAEALDVEVIETFVQGSSVIGLLLTGNSRGFVVSGLIQDSELE
ILQEYGDCLLLGEEMNAAGNVILTNDSFAVVHPDMSSAMREMVADFLKVKIIPMSFAGVGTVGMTCACTNTGVLLPARST
PEEIEKLERSIDDANVAIGTGSVNMGSGLIGTGLLINSKGYLAGNATTGYELGRIEDVFGFL

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=220, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI31563378, Length=220, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17506075, Length=219, Percent_Identity=27.3972602739726, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325273, Length=213, Percent_Identity=30.0469483568075, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21492634, Length=223, Percent_Identity=27.3542600896861, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_METLZ (A2STI7)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030910.1
- ProteinModelPortal:   A2STI7
- SMR:   A2STI7
- STRING:   A2STI7
- GeneID:   4795544
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1478
- eggNOG:   arNOG10240
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- PhylomeDB:   A2STI7
- ProtClustDB:   PRK04046
- BioCyc:   MLAB410358:MLAB_1478-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 23440; Mature: 23440

Theoretical pI: Translated: 3.95; Mature: 3.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPTLSLNGDPNIGVYARVFEDLAVVPVEAPKEFRDKIAEALDVEVIETFVQGSSVIGLL
CCCCEECCCCCCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LTGNSRGFVVSGLIQDSELEILQEYGDCLLLGEEMNAAGNVILTNDSFAVVHPDMSSAMR
EECCCCCEEEEEEECCHHHHHHHHCCCEEEECCCCCCCCCEEEECCCEEEECCCHHHHHH
EMVADFLKVKIIPMSFAGVGTVGMTCACTNTGVLLPARSTPEEIEKLERSIDDANVAIGT
HHHHHHHEEEEEEEECCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCEEEEEC
GSVNMGSGLIGTGLLINSKGYLAGNATTGYELGRIEDVFGFL
CCCCCCCCCEECCEEEECCCEEECCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MDPTLSLNGDPNIGVYARVFEDLAVVPVEAPKEFRDKIAEALDVEVIETFVQGSSVIGLL
CCCCEECCCCCCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LTGNSRGFVVSGLIQDSELEILQEYGDCLLLGEEMNAAGNVILTNDSFAVVHPDMSSAMR
EECCCCCEEEEEEECCHHHHHHHHCCCEEEECCCCCCCCCEEEECCCEEEECCCHHHHHH
EMVADFLKVKIIPMSFAGVGTVGMTCACTNTGVLLPARSTPEEIEKLERSIDDANVAIGT
HHHHHHHEEEEEEEECCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCEEEEEC
GSVNMGSGLIGTGLLINSKGYLAGNATTGYELGRIEDVFGFL
CCCCCCCCCEECCEEEECCCEEECCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA