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The map label for this gene is srp54

Identifier: 124486290

GI number: 124486290

Start: 1512129

End: 1513469

Strand: Reverse

Name: srp54

Synonym: Mlab_1474

Alternate gene names: 124486290

Gene position: 1513469-1512129 (Counterclockwise)

Preceding gene: 124486291

Following gene: 124486287

Centisome position: 83.85

GC content: 52.65

Gene sequence:

>1341_bases
ATGGGACTTGATACACTTTCCAACTCACTCAAAGACGCGATGAAAAAACTCGCCGGCAAAACTGTCATCGACCGTGCTGC
CGTCGACGAACTCGTTCGCGATCTCCAGCGGGCTCTGCTCTCATCCGACGTAAACGTCAAACTCGTGATGGAGCTTTCCA
AGCAGATCAAAGCCCGCTCGCTGGACGAAGATCTTCCCAAAGGCATCAACGCCCGTGAACATGTTCTCAGGATCGTGTAT
CAGGAGCTGGTGAATCTTGTCGGCAAAGAGGCTGAGTTCTCCTTAAAACCGCAGAAGATCCTTATGGCCGGTCTGCAGGG
ATCGGGTAAGACCACTACGACCGGAAAACTCTGCCGCTACTTCCAGAGAAAAGGGCTGAAAGTAGGGGCGATCGGCGCCG
ACAACTTCAGGCCGGGAGCGTATGCCCAGCTGGAAACGCTCTGTAAAAAGATCAATGTTCCAAGTTACGGTGATCCAAAG
GAGAAAGACGCCGTAAAAATCGTTAAAGACGGACTTGCCGCTCTCAAAGATGTGGATGTCATCATCGTCGATACCGCCGG
CCGTCATGCGCTGGAGGATGACCTGATCGATGAGATTACGCAGGTCAACGCATACCTCAACCCCGATCACCGCTGGCTCG
TCATCGACGCCGCTCTCGGTCAGGCGGCCCGCGATCAGGCCAAACGGTTCCATGAAGCGATCGGCATCGACGGCGTTATC
GTAACCAAGATGGACGGTACGGCGAAAGGAGGAGGCGCCATGTCTGCTGTCGCCGAGACCCAGTCCGGAATCGTTTTCAT
CGGTAACGGTGAGACGATCGACGATCTCGAACGCTTCGATCCCAACGGATTCATCTCCAGACTTCTCGGTATGGGCGATC
TCAAAGCCCTCGTTGAAAAGGCCGAAGAGTCGATGAACGCCGAGGATGTCGATGTCAACGCCATGCTTCGGGGAAAGTTT
ACGCTGAATGATATGTACAAACAGCTCGAAGCGGTTCAGAAGATGGGTCCGTTAAAGCAGGTCCTCTCCATGCTGCCGAT
GGGCAACATGAACGTTCCGTCCGACGCTCTGGAAGGAACCGCCGACAAGATGAAAAAGTTTAGGATCATCATGGACTCCA
TGACCCCTCAGGAACTTGACGAACCTGCTTTGATCAACACATCCAGAATGATACGGGTCGCCAAAGGTTCCGGTTCTTCG
GTTGAAGAGGTCAGGGATCTCATCAAATATTATAAGATGATGCAGAAAACCCTGAAAGGATTCAGAGGAAACAGAATGGC
GATGGGCAAAATGATGAAACAAATGCAGAAAGGCGGCATGGGACCTATGGGTCCAATGTAA

Upstream 100 bases:

>100_bases
GGAAAACCGCTTGTTTTCCTCGGAGTCGGGCAGGGGTATGACGATATGAAACCATTCACTCCTTCGCTGATTATTGATGA
AATATTCGGAGATGACTAAC

Downstream 100 bases:

>100_bases
ACTCGTTTTTTATTACGATTTCGTATAGCTTATATTATAATTGTCTGTCCCGGTTCCGTCAGGGAGGATGGTAAAGTGGA
TCAATGCCTCTTCGTAATAA

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MGLDTLSNSLKDAMKKLAGKTVIDRAAVDELVRDLQRALLSSDVNVKLVMELSKQIKARSLDEDLPKGINAREHVLRIVY
QELVNLVGKEAEFSLKPQKILMAGLQGSGKTTTTGKLCRYFQRKGLKVGAIGADNFRPGAYAQLETLCKKINVPSYGDPK
EKDAVKIVKDGLAALKDVDVIIVDTAGRHALEDDLIDEITQVNAYLNPDHRWLVIDAALGQAARDQAKRFHEAIGIDGVI
VTKMDGTAKGGGAMSAVAETQSGIVFIGNGETIDDLERFDPNGFISRLLGMGDLKALVEKAEESMNAEDVDVNAMLRGKF
TLNDMYKQLEAVQKMGPLKQVLSMLPMGNMNVPSDALEGTADKMKKFRIIMDSMTPQELDEPALINTSRMIRVAKGSGSS
VEEVRDLIKYYKMMQKTLKGFRGNRMAMGKMMKQMQKGGMGPMGPM

Sequences:

>Translated_446_residues
MGLDTLSNSLKDAMKKLAGKTVIDRAAVDELVRDLQRALLSSDVNVKLVMELSKQIKARSLDEDLPKGINAREHVLRIVY
QELVNLVGKEAEFSLKPQKILMAGLQGSGKTTTTGKLCRYFQRKGLKVGAIGADNFRPGAYAQLETLCKKINVPSYGDPK
EKDAVKIVKDGLAALKDVDVIIVDTAGRHALEDDLIDEITQVNAYLNPDHRWLVIDAALGQAARDQAKRFHEAIGIDGVI
VTKMDGTAKGGGAMSAVAETQSGIVFIGNGETIDDLERFDPNGFISRLLGMGDLKALVEKAEESMNAEDVDVNAMLRGKF
TLNDMYKQLEAVQKMGPLKQVLSMLPMGNMNVPSDALEGTADKMKKFRIIMDSMTPQELDEPALINTSRMIRVAKGSGSS
VEEVRDLIKYYKMMQKTLKGFRGNRMAMGKMMKQMQKGGMGPMGPM
>Mature_445_residues
GLDTLSNSLKDAMKKLAGKTVIDRAAVDELVRDLQRALLSSDVNVKLVMELSKQIKARSLDEDLPKGINAREHVLRIVYQ
ELVNLVGKEAEFSLKPQKILMAGLQGSGKTTTTGKLCRYFQRKGLKVGAIGADNFRPGAYAQLETLCKKINVPSYGDPKE
KDAVKIVKDGLAALKDVDVIIVDTAGRHALEDDLIDEITQVNAYLNPDHRWLVIDAALGQAARDQAKRFHEAIGIDGVIV
TKMDGTAKGGGAMSAVAETQSGIVFIGNGETIDDLERFDPNGFISRLLGMGDLKALVEKAEESMNAEDVDVNAMLRGKFT
LNDMYKQLEAVQKMGPLKQVLSMLPMGNMNVPSDALEGTADKMKKFRIIMDSMTPQELDEPALINTSRMIRVAKGSGSSV
EEVRDLIKYYKMMQKTLKGFRGNRMAMGKMMKQMQKGGMGPMGPM

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=464, Percent_Identity=40.948275862069, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI226371618, Length=402, Percent_Identity=42.7860696517413, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=51.0344827586207, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI23308697, Length=314, Percent_Identity=24.203821656051, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI295424842, Length=314, Percent_Identity=24.203821656051, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=35.2941176470588, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789874, Length=220, Percent_Identity=38.1818181818182, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539958, Length=433, Percent_Identity=39.0300230946882, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI193206261, Length=220, Percent_Identity=30.4545454545455, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6325345, Length=410, Percent_Identity=41.4634146341463, Blast_Score=299, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=38.1818181818182, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=30.4545454545455, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_METLZ (A2STI3)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030906.1
- ProteinModelPortal:   A2STI3
- SMR:   A2STI3
- STRING:   A2STI3
- GeneID:   4795584
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1474
- eggNOG:   arNOG04631
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- PhylomeDB:   A2STI3
- ProtClustDB:   PRK00771
- BioCyc:   MLAB410358:MLAB_1474-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 48858; Mature: 48727

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLDTLSNSLKDAMKKLAGKTVIDRAAVDELVRDLQRALLSSDVNVKLVMELSKQIKARS
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
LDEDLPKGINAREHVLRIVYQELVNLVGKEAEFSLKPQKILMAGLQGSGKTTTTGKLCRY
CHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHH
FQRKGLKVGAIGADNFRPGAYAQLETLCKKINVPSYGDPKEKDAVKIVKDGLAALKDVDV
HHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
IIVDTAGRHALEDDLIDEITQVNAYLNPDHRWLVIDAALGQAARDQAKRFHEAIGIDGVI
EEEECCCCHHHHHHHHHHHHHHHCEECCCCCEEEEEHHHCHHHHHHHHHHHHHHCCCCEE
VTKMDGTAKGGGAMSAVAETQSGIVFIGNGETIDDLERFDPNGFISRLLGMGDLKALVEK
EEECCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHHHHHCCHHHHHHHHH
AEESMNAEDVDVNAMLRGKFTLNDMYKQLEAVQKMGPLKQVLSMLPMGNMNVPSDALEGT
HHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHCCC
ADKMKKFRIIMDSMTPQELDEPALINTSRMIRVAKGSGSSVEEVRDLIKYYKMMQKTLKG
HHHHHHHHHHHHCCCHHHCCCCCEECHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
FRGNRMAMGKMMKQMQKGGMGPMGPM
CCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GLDTLSNSLKDAMKKLAGKTVIDRAAVDELVRDLQRALLSSDVNVKLVMELSKQIKARS
CHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
LDEDLPKGINAREHVLRIVYQELVNLVGKEAEFSLKPQKILMAGLQGSGKTTTTGKLCRY
CHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHH
FQRKGLKVGAIGADNFRPGAYAQLETLCKKINVPSYGDPKEKDAVKIVKDGLAALKDVDV
HHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
IIVDTAGRHALEDDLIDEITQVNAYLNPDHRWLVIDAALGQAARDQAKRFHEAIGIDGVI
EEEECCCCHHHHHHHHHHHHHHHCEECCCCCEEEEEHHHCHHHHHHHHHHHHHHCCCCEE
VTKMDGTAKGGGAMSAVAETQSGIVFIGNGETIDDLERFDPNGFISRLLGMGDLKALVEK
EEECCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHHHHHCCHHHHHHHHH
AEESMNAEDVDVNAMLRGKFTLNDMYKQLEAVQKMGPLKQVLSMLPMGNMNVPSDALEGT
HHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHCCC
ADKMKKFRIIMDSMTPQELDEPALINTSRMIRVAKGSGSSVEEVRDLIKYYKMMQKTLKG
HHHHHHHHHHHHCCCHHHCCCCCEECHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
FRGNRMAMGKMMKQMQKGGMGPMGPM
CCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA