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The map label for this gene is guaB [H]

Identifier: 124486199

GI number: 124486199

Start: 1408552

End: 1410021

Strand: Reverse

Name: guaB [H]

Synonym: Mlab_1382

Alternate gene names: 124486199

Gene position: 1410021-1408552 (Counterclockwise)

Preceding gene: 124486200

Following gene: 124486185

Centisome position: 78.12

GC content: 53.61

Gene sequence:

>1470_bases
ATGTTTGGAGAAAAACTCAACATCCCTACGGCACTCACCTTCGATGATGTGCTGATTGAACCGGCAGAATCCTGGATAGA
GCCAAATGATGTAGATGTTCGATCCAGATTCTCTAAAAACATTTCACTCTCCATACCTTTGGTGAGTGCGGCAATGGACA
CAGTTACCGAGGCGGAAATGGCAATTTCTATGGCACGCGCCGGAGGTATCGGCGTTCTGCACAGAAACTGTACGCCCGAT
GAAGAGGTCTCCTTTGTCACCCGCGTTAAGTCGGCTGACAATGTCATCGAACGTGATGTCAGATACGTGACCCCCGACAC
GACCATTGCTCTTGTGGCAAATCTCATGGACCGCCACTCGATCGGCGGCGTGCCGGTCGTTGGTCCTCACGGCAAACTTC
TCGGCATCGTTTCGCGCCGGGATGTCCGCGGCCTTGTTAACAAGACCGGGACGGAAACCGTCGAAACGATCATGACCAAA
AAACCGATCGCCGTGAAAGACAATATCACTGCAGATGATGCCATCAATATGATGTACACCAAAAAGGTCGAGCGTCTTCC
GGTCGTTGATGACAAAGGCAGACTGACAGGTATCATCACCATGCAGGATCTGCTTGAAAAACAGCAGTATCCGAAAGCCA
ACCGCGATGCAAACGGAAAACTCCGTGTCGCCGCCGCAGTTGGACCGTTCGACATGGAGCGTGCATTAAAACTCGCAGAG
GCAGGCGTTGATGCGATCGTTGTGGACTGTGCCCACGGCCATAATATGCATGTTGTCCAGGGAGTAAAAGCGATCAAAGG
CGCCGTCTCATGCGATGTCGTCGCCGGAAATATCGCCACCTCGAAAGCTGCCGGCGAACTTGTAGGGTTCGTTGACGGGA
TCAAAGTCGGCATCGGTCCAGGTTCGATTTGTACGACCCGTATCGTTGCTGGTGTCGGCGTTCCGCAGATCTCTGCCATC
GCCAACGTATGTGATGTCGCAGATCCATGTGGCGTCCCGGTCATCGCAGACGGCGGCGTCAAATACAGCGGTGATGTGGC
CAAGGCAATCGTAGCTGGCGCTTCGTCAGTAATGATGGGCAGTATGTTTGCCGGAACCGACGAGGCTCCAGGTAAAACGA
TCATCGTCAAAGGCCGGAGATACAAACAGTACCGCGGCATGGGATCGCTCGGCGTCATGACCTCTGGAAATTCAAGCGAC
CGCTACTTCCAGAAGAAAGGTATCGGCTCGACCAAGTATGTTCCGGAAGGCGTCGAAGGTGCCACTCCGTATGTCGGTTC
CGTGACCGATGTCATCTATCAGACGATCGGCGGTCTCAAATCGGCGATGGGATATTCCGGAAGCAAGGATATCGAAACTA
TGCGGACGAATGCCAGGTTCGTCAGAATTACCTCCGCGGGACTGAAAGAGTCCCACCCCCACGACATCCTGATCACCGAT
GAAGCACCGAACTACCGTACCAATCTCTGA

Upstream 100 bases:

>100_bases
AGATCATCGGTGTCCGCGGCATGGTTTGCGGCGGAGACAGAACAACCATGGTTCAGGAAAGTCTCGTAAAGAAAGCGATT
CAGATGGTAAGGTAAACAAC

Downstream 100 bases:

>100_bases
ATTGGTACTTCTGTTTTTATTCCGAAATTAAAAAGAATAGGACTTACACGTTGTTATCCTTAATCCACGTCGGTAAGGGT
ATTACTGGGTGTTGAAACAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MFGEKLNIPTALTFDDVLIEPAESWIEPNDVDVRSRFSKNISLSIPLVSAAMDTVTEAEMAISMARAGGIGVLHRNCTPD
EEVSFVTRVKSADNVIERDVRYVTPDTTIALVANLMDRHSIGGVPVVGPHGKLLGIVSRRDVRGLVNKTGTETVETIMTK
KPIAVKDNITADDAINMMYTKKVERLPVVDDKGRLTGIITMQDLLEKQQYPKANRDANGKLRVAAAVGPFDMERALKLAE
AGVDAIVVDCAHGHNMHVVQGVKAIKGAVSCDVVAGNIATSKAAGELVGFVDGIKVGIGPGSICTTRIVAGVGVPQISAI
ANVCDVADPCGVPVIADGGVKYSGDVAKAIVAGASSVMMGSMFAGTDEAPGKTIIVKGRRYKQYRGMGSLGVMTSGNSSD
RYFQKKGIGSTKYVPEGVEGATPYVGSVTDVIYQTIGGLKSAMGYSGSKDIETMRTNARFVRITSAGLKESHPHDILITD
EAPNYRTNL

Sequences:

>Translated_489_residues
MFGEKLNIPTALTFDDVLIEPAESWIEPNDVDVRSRFSKNISLSIPLVSAAMDTVTEAEMAISMARAGGIGVLHRNCTPD
EEVSFVTRVKSADNVIERDVRYVTPDTTIALVANLMDRHSIGGVPVVGPHGKLLGIVSRRDVRGLVNKTGTETVETIMTK
KPIAVKDNITADDAINMMYTKKVERLPVVDDKGRLTGIITMQDLLEKQQYPKANRDANGKLRVAAAVGPFDMERALKLAE
AGVDAIVVDCAHGHNMHVVQGVKAIKGAVSCDVVAGNIATSKAAGELVGFVDGIKVGIGPGSICTTRIVAGVGVPQISAI
ANVCDVADPCGVPVIADGGVKYSGDVAKAIVAGASSVMMGSMFAGTDEAPGKTIIVKGRRYKQYRGMGSLGVMTSGNSSD
RYFQKKGIGSTKYVPEGVEGATPYVGSVTDVIYQTIGGLKSAMGYSGSKDIETMRTNARFVRITSAGLKESHPHDILITD
EAPNYRTNL
>Mature_489_residues
MFGEKLNIPTALTFDDVLIEPAESWIEPNDVDVRSRFSKNISLSIPLVSAAMDTVTEAEMAISMARAGGIGVLHRNCTPD
EEVSFVTRVKSADNVIERDVRYVTPDTTIALVANLMDRHSIGGVPVVGPHGKLLGIVSRRDVRGLVNKTGTETVETIMTK
KPIAVKDNITADDAINMMYTKKVERLPVVDDKGRLTGIITMQDLLEKQQYPKANRDANGKLRVAAAVGPFDMERALKLAE
AGVDAIVVDCAHGHNMHVVQGVKAIKGAVSCDVVAGNIATSKAAGELVGFVDGIKVGIGPGSICTTRIVAGVGVPQISAI
ANVCDVADPCGVPVIADGGVKYSGDVAKAIVAGASSVMMGSMFAGTDEAPGKTIIVKGRRYKQYRGMGSLGVMTSGNSSD
RYFQKKGIGSTKYVPEGVEGATPYVGSVTDVIYQTIGGLKSAMGYSGSKDIETMRTNARFVRITSAGLKESHPHDILITD
EAPNYRTNL

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=486, Percent_Identity=37.037037037037, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=37.5824175824176, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=37.5824175824176, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=37.5824175824176, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=37.5824175824176, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=37.4722838137472, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=37.5824175824176, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=35.8241758241758, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI156104880, Length=295, Percent_Identity=33.5593220338983, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI50541954, Length=297, Percent_Identity=33.6700336700337, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI50541952, Length=297, Percent_Identity=33.6700336700337, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI50541948, Length=297, Percent_Identity=33.6700336700337, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI50541956, Length=297, Percent_Identity=33.6700336700337, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=45.4166666666667, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1786293, Length=275, Percent_Identity=31.2727272727273, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71994385, Length=481, Percent_Identity=31.8087318087318, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71994389, Length=429, Percent_Identity=33.1002331002331, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=35.6846473029046, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=35.8178053830228, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=36.231884057971, Blast_Score=293, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=36.231884057971, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=35.7988165680473, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=36.9747899159664, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=36.7219917012448, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=36.7219917012448, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=36.6515837104072, Blast_Score=245, Evalue=5e-65,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51753; Mature: 51753

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGEKLNIPTALTFDDVLIEPAESWIEPNDVDVRSRFSKNISLSIPLVSAAMDTVTEAEM
CCCCCCCCCEEEEHHHHHCCCHHHCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHH
AISMARAGGIGVLHRNCTPDEEVSFVTRVKSADNVIERDVRYVTPDTTIALVANLMDRHS
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHC
IGGVPVVGPHGKLLGIVSRRDVRGLVNKTGTETVETIMTKKPIAVKDNITADDAINMMYT
CCCCEEECCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHH
KKVERLPVVDDKGRLTGIITMQDLLEKQQYPKANRDANGKLRVAAAVGPFDMERALKLAE
HHHHHCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHH
AGVDAIVVDCAHGHNMHVVQGVKAIKGAVSCDVVAGNIATSKAAGELVGFVDGIKVGIGP
CCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCEEECCCC
GSICTTRIVAGVGVPQISAIANVCDVADPCGVPVIADGGVKYSGDVAKAIVAGASSVMMG
CHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCEEECCHHHHHHHHCCHHHHHH
SMFAGTDEAPGKTIIVKGRRYKQYRGMGSLGVMTSGNSSDRYFQKKGIGSTKYVPEGVEG
HHHCCCCCCCCCEEEEECCHHHHHCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCC
ATPYVGSVTDVIYQTIGGLKSAMGYSGSKDIETMRTNARFVRITSAGLKESHPHDILITD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCEEEEEC
EAPNYRTNL
CCCCCCCCC
>Mature Secondary Structure
MFGEKLNIPTALTFDDVLIEPAESWIEPNDVDVRSRFSKNISLSIPLVSAAMDTVTEAEM
CCCCCCCCCEEEEHHHHHCCCHHHCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHH
AISMARAGGIGVLHRNCTPDEEVSFVTRVKSADNVIERDVRYVTPDTTIALVANLMDRHS
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHC
IGGVPVVGPHGKLLGIVSRRDVRGLVNKTGTETVETIMTKKPIAVKDNITADDAINMMYT
CCCCEEECCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHH
KKVERLPVVDDKGRLTGIITMQDLLEKQQYPKANRDANGKLRVAAAVGPFDMERALKLAE
HHHHHCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHH
AGVDAIVVDCAHGHNMHVVQGVKAIKGAVSCDVVAGNIATSKAAGELVGFVDGIKVGIGP
CCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCEEECCCC
GSICTTRIVAGVGVPQISAIANVCDVADPCGVPVIADGGVKYSGDVAKAIVAGASSVMMG
CHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCEEECCHHHHHHHHCCHHHHHH
SMFAGTDEAPGKTIIVKGRRYKQYRGMGSLGVMTSGNSSDRYFQKKGIGSTKYVPEGVEG
HHHCCCCCCCCCEEEEECCHHHHHCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCC
ATPYVGSVTDVIYQTIGGLKSAMGYSGSKDIETMRTNARFVRITSAGLKESHPHDILITD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCEEEEEC
EAPNYRTNL
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]