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The map label for this gene is fbp

Identifier: 124486146

GI number: 124486146

Start: 1357709

End: 1358530

Strand: Reverse

Name: fbp

Synonym: Mlab_1328

Alternate gene names: 124486146

Gene position: 1358530-1357709 (Counterclockwise)

Preceding gene: 124486147

Following gene: 124486145

Centisome position: 75.27

GC content: 57.3

Gene sequence:

>822_bases
ATGATGATCGCGGACCAGGCAGGACCGATCCGTTCCGCGTTTATCAGCAACCAGAATTATGCGGGCTCCACGAACTCTTC
CGGCGAGGATCAGGCCGAGATGGACACCTGGGCCGACACCAGGATCACCTCAGTTCTCCAGGAAAGCGGGCTTGTCCGTT
CCATTGCTTCCGAAGAACAGGAGGATATCACCGAGATGTCTCCTTCTGCGAAGTATTCGGTCGTGATGGATCCCCTAGAC
GGCTCCTCGCTTATCAAGGTAAATCTGACCGTCGGGACGATCGTCGGGATCTATGAAGGCGACGTTCTTCAGGCGGGTAA
CAAGCTTCGCGCCGCATTCTATATGCTCTACGGCCCGCTGACGACGCTGACGATCTCGCTTGGGAACGGGGTCTCGATCT
TTGCGATGAATGAGGAAGGCACCTACGTTCTCTTAAAAGAGAATGTGAGGATTCCGGAAGGCACGCTCTGCGGAAGCGGC
GGTCTGCGGCCCGAGTGGACCGAGAAACACATTCAGTACATGAATGCGATCGAGTGCGAAGGCGGAAAGAACCGGTACTC
CGGCTCTTTCGTGGCCGACTTCCACCAGATCCTGGAGTACGGCGGCGTGTATGCCTATCCGGCGACGAAGAAGTCCGCGT
CCGGGAAACTGCGGCTGGTCTTCGAGATCAACCCGATCGGTTTCCTCGCGGTCCAGGCAGGAGGGGCAGTCTCGAACGGC
GAGTCTTCGACCCTTGAGATCGTCCCGACAAAGGTTCATCAGAGAACGCCCGTGTATGTCGGCAGCAAAGGGATGATCGC
GAAAATCGAGGCGATTCGCTGA

Upstream 100 bases:

>100_bases
ACGTTTTTTTGCCTCCAGCACGCATATCATAGATACTATGAAAACCTTGCAGGAGTATCTTTCCGCCTCACATGCCCCTG
AGGATTTGGGAAAAATAATC

Downstream 100 bases:

>100_bases
ACATGCACACGACGGTCTCGGTCTTTGCAAAGCCGGTCGGCGGGGTCTCCGGGACGACCCGGGTCTTCCCCGATATCCTC
CAGACGGCGGCAAAGATGCT

Product: D-fructose 1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MMIADQAGPIRSAFISNQNYAGSTNSSGEDQAEMDTWADTRITSVLQESGLVRSIASEEQEDITEMSPSAKYSVVMDPLD
GSSLIKVNLTVGTIVGIYEGDVLQAGNKLRAAFYMLYGPLTTLTISLGNGVSIFAMNEEGTYVLLKENVRIPEGTLCGSG
GLRPEWTEKHIQYMNAIECEGGKNRYSGSFVADFHQILEYGGVYAYPATKKSASGKLRLVFEINPIGFLAVQAGGAVSNG
ESSTLEIVPTKVHQRTPVYVGSKGMIAKIEAIR

Sequences:

>Translated_273_residues
MMIADQAGPIRSAFISNQNYAGSTNSSGEDQAEMDTWADTRITSVLQESGLVRSIASEEQEDITEMSPSAKYSVVMDPLD
GSSLIKVNLTVGTIVGIYEGDVLQAGNKLRAAFYMLYGPLTTLTISLGNGVSIFAMNEEGTYVLLKENVRIPEGTLCGSG
GLRPEWTEKHIQYMNAIECEGGKNRYSGSFVADFHQILEYGGVYAYPATKKSASGKLRLVFEINPIGFLAVQAGGAVSNG
ESSTLEIVPTKVHQRTPVYVGSKGMIAKIEAIR
>Mature_273_residues
MMIADQAGPIRSAFISNQNYAGSTNSSGEDQAEMDTWADTRITSVLQESGLVRSIASEEQEDITEMSPSAKYSVVMDPLD
GSSLIKVNLTVGTIVGIYEGDVLQAGNKLRAAFYMLYGPLTTLTISLGNGVSIFAMNEEGTYVLLKENVRIPEGTLCGSG
GLRPEWTEKHIQYMNAIECEGGKNRYSGSFVADFHQILEYGGVYAYPATKKSASGKLRLVFEINPIGFLAVQAGGAVSNG
ESSTLEIVPTKVHQRTPVYVGSKGMIAKIEAIR

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=261, Percent_Identity=36.7816091954023, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI16579888, Length=261, Percent_Identity=36.7816091954023, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI22907028, Length=267, Percent_Identity=35.5805243445693, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1790679, Length=272, Percent_Identity=39.7058823529412, Blast_Score=184, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17508131, Length=262, Percent_Identity=35.8778625954198, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323409, Length=280, Percent_Identity=34.2857142857143, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI45550998, Length=273, Percent_Identity=38.8278388278388, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI19921562, Length=273, Percent_Identity=38.8278388278388, Blast_Score=167, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_METLZ (A2ST39)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030762.1
- STRING:   A2ST39
- GeneID:   4794821
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1328
- eggNOG:   arNOG06461
- HOGENOM:   HBG731261
- ProtClustDB:   CLSK949627
- BioCyc:   MLAB410358:MLAB_1328-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 29383; Mature: 29383

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00124 FBPASE

Important sites: BINDING 233-233 BINDING 263-263

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIADQAGPIRSAFISNQNYAGSTNSSGEDQAEMDTWADTRITSVLQESGLVRSIASEEQ
CEECCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EDITEMSPSAKYSVVMDPLDGSSLIKVNLTVGTIVGIYEGDVLQAGNKLRAAFYMLYGPL
HHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEEEEEEECCCHHHCCCHHHEEEHEEECCC
TTLTISLGNGVSIFAMNEEGTYVLLKENVRIPEGTLCGSGGLRPEWTEKHIQYMNAIECE
EEEEEEECCCEEEEEECCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHEEECC
GGKNRYSGSFVADFHQILEYGGVYAYPATKKSASGKLRLVFEINPIGFLAVQAGGAVSNG
CCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCC
ESSTLEIVPTKVHQRTPVYVGSKGMIAKIEAIR
CCCEEEEEECCCCCCCCEEECCCCCEEEEEECC
>Mature Secondary Structure
MMIADQAGPIRSAFISNQNYAGSTNSSGEDQAEMDTWADTRITSVLQESGLVRSIASEEQ
CEECCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EDITEMSPSAKYSVVMDPLDGSSLIKVNLTVGTIVGIYEGDVLQAGNKLRAAFYMLYGPL
HHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEEEEEEECCCHHHCCCHHHEEEHEEECCC
TTLTISLGNGVSIFAMNEEGTYVLLKENVRIPEGTLCGSGGLRPEWTEKHIQYMNAIECE
EEEEEEECCCEEEEEECCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHEEECC
GGKNRYSGSFVADFHQILEYGGVYAYPATKKSASGKLRLVFEINPIGFLAVQAGGAVSNG
CCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCC
ESSTLEIVPTKVHQRTPVYVGSKGMIAKIEAIR
CCCEEEEEECCCCCCCCEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA