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The map label for this gene is prsA [H]

Identifier: 124486132

GI number: 124486132

Start: 1339583

End: 1339864

Strand: Reverse

Name: prsA [H]

Synonym: Mlab_1314

Alternate gene names: 124486132

Gene position: 1339864-1339583 (Counterclockwise)

Preceding gene: 124486133

Following gene: 124486131

Centisome position: 74.23

GC content: 50.0

Gene sequence:

>282_bases
ATGGTACGGGTAAAAGCATCCCACATTTTAGTAAAGACCGAAGCTCAAGCAAAAGAGATCATGCAGAAGATCTCTGCCGG
CGATGATTTTGCCAAACTCGCCAAAATGTATTCGCAGTGTCCGTCAGGCAATGCCGGCGGCGACCTCGGCTATTTCGGCA
AAGGCCAGATGGTGAAACCCTTCGAAGACGCCTGTTTCAAGGCAAAAGCCGGCGATGTTGTGGGCCCGGTCAAAACCCAG
TTCGGCTGGCATATCATCAAAGTAACCGATATTAAGAACTGA

Upstream 100 bases:

>100_bases
TTGACGGGGGTGTCGAGGCCTCTTCTGCTATCCTCGATCACGTCTGGATGCCGTGAAAAACCATAGAGCTTATTGGCAGT
GAATACGATATGATAGACGT

Downstream 100 bases:

>100_bases
TCCTCTATGAAAAAATCTGCCTTCGATGACTTAGTCGCTGCTGTCAGGAGTGATGACAGCGCAAGGCAGGAGTCTGCGGC
GAACAAGATCTGTTCATTGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 93; Mature: 93

Protein sequence:

>93_residues
MVRVKASHILVKTEAQAKEIMQKISAGDDFAKLAKMYSQCPSGNAGGDLGYFGKGQMVKPFEDACFKAKAGDVVGPVKTQ
FGWHIIKVTDIKN

Sequences:

>Translated_93_residues
MVRVKASHILVKTEAQAKEIMQKISAGDDFAKLAKMYSQCPSGNAGGDLGYFGKGQMVKPFEDACFKAKAGDVVGPVKTQ
FGWHIIKVTDIKN
>Mature_93_residues
MVRVKASHILVKTEAQAKEIMQKISAGDDFAKLAKMYSQCPSGNAGGDLGYFGKGQMVKPFEDACFKAKAGDVVGPVKTQ
FGWHIIKVTDIKN

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=111, Percent_Identity=42.3423423423423, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=53.0120481927711, Blast_Score=91, Evalue=2e-20,
Organism=Escherichia coli, GI1786238, Length=104, Percent_Identity=36.5384615384615, Blast_Score=61, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537235, Length=91, Percent_Identity=38.4615384615385, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=110, Percent_Identity=36.3636363636364, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356303, Length=91, Percent_Identity=41.7582417582418, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF05698 Trigger_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 10077; Mature: 10077

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVKASHILVKTEAQAKEIMQKISAGDDFAKLAKMYSQCPSGNAGGDLGYFGKGQMVKP
CEEECCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
FEDACFKAKAGDVVGPVKTQFGWHIIKVTDIKN
HHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MVRVKASHILVKTEAQAKEIMQKISAGDDFAKLAKMYSQCPSGNAGGDLGYFGKGQMVKP
CEEECCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
FEDACFKAKAGDVVGPVKTQFGWHIIKVTDIKN
HHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA