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The map label for this gene is hom [H]

Identifier: 124485306

GI number: 124485306

Start: 455302

End: 456288

Strand: Reverse

Name: hom [H]

Synonym: Mlab_0481

Alternate gene names: 124485306

Gene position: 456288-455302 (Counterclockwise)

Preceding gene: 124485307

Following gene: 124485305

Centisome position: 25.28

GC content: 52.99

Gene sequence:

>987_bases
ATGAAAACATGGAATGTCGCGCTGATCGGCCTTGGTTCGGTCGGACGCGGTGTCGCAGAAGTCCTCGCAGGAGATGAGCG
GTTCCGGATCGTTGCCGCCGCGGATTCAAAAAGCGGCGTAATTGATCCTGCCGGCCTCAATATAGAAGAGATTCTTGCAA
AGAAAAAGAAGACCGGACGCTGCGGGGACCCCGCCTGGCCCGCGGCACGAATCTCGGCCGAAGCTGAATACGATATCCTT
GTCGAGGTTACTCCTACAAACGCCGAGACTGGCGAACCAGCACTTTCTATCATCAAAACCGCGATCATGCGGGGAAAGCA
TGTCGTCACTTCGAACAAAGGACCTGTCTCTCTCGCTTCAGCCGAACTGCTCAGACTGGCGGAAGAAAATAACGTTGGAT
TCCTTTTCGAAGGAACCGTGGCAGGCGCCGTACCAATTCTTCGCGGGATAAAATACGGACTTGCCGGCAACAAAATCAAA
GCACTCTACGGCGTTTTAAACGGAACCTGCAATTATATTCTGACCAGAATGGAGGAAGAGGGTTTGACGTATGTCCAGGC
ACTCGCCGAAGCACGCGATCTTGGATATGCCGAGGCAGATCCCACTTACGATATTAACGGGACCGATGCCGCGATCAAAC
TCGTCATCCTTGCAAATACCATGCTCGGGATGGATGTGAAACTTGACGATGTTCAACGTACCGGCATATCGGATTTGACC
GTTGATGCTCTCTTGATGGCCGAAGAAACAGGACACTCGATACGGCTGATTGCAACCCTTCACCCGGAAAAGAATCTTCT
GGAGGTCTCGCCGCGGCTTATCTCCAAAACCAATCCGCTTGTCGTTACCGGCACGTTGAACGCAGTGACCGTTGAAACCG
AGTATGCCGGCGCGATCACCTTCATCGGCCGGGGCGCAGGATCTGTTGAAACGGCCAGTGCGATCCTGGCGGATCTTCTC
TTTATCACAGACAAATATGACCGGTAA

Upstream 100 bases:

>100_bases
AAGCCGTAAGTGAACAGGAGATGACTCAGGCAGTGATAACGCTTAAAGAAATCGCCGTGGAAAAACATCTTCTCATCATC
AACCAGATAGGAGGCGGCTT

Downstream 100 bases:

>100_bases
GGAAAAATCCGGCGGCGTCCTCGAACGCCGCGGAGCATTTCTCACAGCCATGAGGCAGATGACCTTCGAAGCAGGGCACT
TCACCACTGCTGATCTGGCA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKTWNVALIGLGSVGRGVAEVLAGDERFRIVAAADSKSGVIDPAGLNIEEILAKKKKTGRCGDPAWPAARISAEAEYDIL
VEVTPTNAETGEPALSIIKTAIMRGKHVVTSNKGPVSLASAELLRLAEENNVGFLFEGTVAGAVPILRGIKYGLAGNKIK
ALYGVLNGTCNYILTRMEEEGLTYVQALAEARDLGYAEADPTYDINGTDAAIKLVILANTMLGMDVKLDDVQRTGISDLT
VDALLMAEETGHSIRLIATLHPEKNLLEVSPRLISKTNPLVVTGTLNAVTVETEYAGAITFIGRGAGSVETASAILADLL
FITDKYDR

Sequences:

>Translated_328_residues
MKTWNVALIGLGSVGRGVAEVLAGDERFRIVAAADSKSGVIDPAGLNIEEILAKKKKTGRCGDPAWPAARISAEAEYDIL
VEVTPTNAETGEPALSIIKTAIMRGKHVVTSNKGPVSLASAELLRLAEENNVGFLFEGTVAGAVPILRGIKYGLAGNKIK
ALYGVLNGTCNYILTRMEEEGLTYVQALAEARDLGYAEADPTYDINGTDAAIKLVILANTMLGMDVKLDDVQRTGISDLT
VDALLMAEETGHSIRLIATLHPEKNLLEVSPRLISKTNPLVVTGTLNAVTVETEYAGAITFIGRGAGSVETASAILADLL
FITDKYDR
>Mature_328_residues
MKTWNVALIGLGSVGRGVAEVLAGDERFRIVAAADSKSGVIDPAGLNIEEILAKKKKTGRCGDPAWPAARISAEAEYDIL
VEVTPTNAETGEPALSIIKTAIMRGKHVVTSNKGPVSLASAELLRLAEENNVGFLFEGTVAGAVPILRGIKYGLAGNKIK
ALYGVLNGTCNYILTRMEEEGLTYVQALAEARDLGYAEADPTYDINGTDAAIKLVILANTMLGMDVKLDDVQRTGISDLT
VDALLMAEETGHSIRLIATLHPEKNLLEVSPRLISKTNPLVVTGTLNAVTVETEYAGAITFIGRGAGSVETASAILADLL
FITDKYDR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=325, Percent_Identity=26.4615384615385, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 34752; Mature: 34752

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTWNVALIGLGSVGRGVAEVLAGDERFRIVAAADSKSGVIDPAGLNIEEILAKKKKTGR
CCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCC
CGDPAWPAARISAEAEYDILVEVTPTNAETGEPALSIIKTAIMRGKHVVTSNKGPVSLAS
CCCCCCCHHEECCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEHHH
AELLRLAEENNVGFLFEGTVAGAVPILRGIKYGLAGNKIKALYGVLNGTCNYILTRMEEE
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHC
GLTYVQALAEARDLGYAEADPTYDINGTDAAIKLVILANTMLGMDVKLDDVQRTGISDLT
CHHHHHHHHHHHHCCCCCCCCCEECCCCHHHEEEEEEECHHHCCCEEECHHHHCCCCHHH
VDALLMAEETGHSIRLIATLHPEKNLLEVSPRLISKTNPLVVTGTLNAVTVETEYAGAIT
HEEEEEECCCCCEEEEEEEECCCCCCEECCHHHHCCCCCEEEEECCEEEEEEECCCCEEE
FIGRGAGSVETASAILADLLFITDKYDR
EEECCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTWNVALIGLGSVGRGVAEVLAGDERFRIVAAADSKSGVIDPAGLNIEEILAKKKKTGR
CCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCC
CGDPAWPAARISAEAEYDILVEVTPTNAETGEPALSIIKTAIMRGKHVVTSNKGPVSLAS
CCCCCCCHHEECCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEHHH
AELLRLAEENNVGFLFEGTVAGAVPILRGIKYGLAGNKIKALYGVLNGTCNYILTRMEEE
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHC
GLTYVQALAEARDLGYAEADPTYDINGTDAAIKLVILANTMLGMDVKLDDVQRTGISDLT
CHHHHHHHHHHHHCCCCCCCCCEECCCCHHHEEEEEEECHHHCCCEEECHHHHCCCCHHH
VDALLMAEETGHSIRLIATLHPEKNLLEVSPRLISKTNPLVVTGTLNAVTVETEYAGAIT
HEEEEEECCCCCEEEEEEEECCCCCCEECCHHHHCCCCCEEEEECCEEEEEEECCCCEEE
FIGRGAGSVETASAILADLLFITDKYDR
EEECCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]