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The map label for this gene is tbp2 [H]

Identifier: 124485272

GI number: 124485272

Start: 428918

End: 429487

Strand: Reverse

Name: tbp2 [H]

Synonym: Mlab_0447

Alternate gene names: 124485272

Gene position: 429487-428918 (Counterclockwise)

Preceding gene: 124485273

Following gene: 124485268

Centisome position: 23.79

GC content: 50.0

Gene sequence:

>570_bases
ATGTCAAACCTTCCCGAAGACTCGCTGAAGATTGAGAATATTGTTGCATCAACCAAGGTGAATGACAGTCTGGACCTTGT
GGCGCTCGCCGCCCAGATTCCGGGAGCGGAATATAATAAACAGCGTTTCCCCGGAGTCGTCCTGCGCATGCAGAATCCGA
AAATTGCGGCCCTGGTTTTCGGATCGGGAAAAGTCGTCCTTACCGGCGCCAAAAGCCTCGAGAATCTGACCAAAGGACTG
GAATACCTGGTAGCTCTCCTAAAAGAGCTCAAGATCAACATTCTGGACAACCCGACCTACACCGTTCAAAACATCGTCAC
CTCGGCCGACCTTGGAAGCCGCATCAATCTCAACAAGATCGCGATGAGCTTCAATCTGGACAAGATCGAGTATGAACCCG
AGCAGTTTCCGGGACTCGTCTACCGGCTCGACGATCCGAAAGTGGTCGTTCTGCTCTTTGGTTCGGGAAAACTTATCATC
ACCGGCGGAAAGAAAACGGCAGATGCAAAGAAAGCGGTCAAAAAGATCTACGATGATCTGATCTCTCTCAAACTTCTGCA
GATAGAATAA

Upstream 100 bases:

>100_bases
CAAACATACCTGGCGTGAATACGATTAAGCATATTTTCCCCCTCTTTTTTTAAGCAACCCACACGAGTATTTATATACTA
ACCTGTATTAACTTATAAAT

Downstream 100 bases:

>100_bases
CCAATATCGATTTTCCTCTGTTTTTTAGATGTTTACGCCAGGAAAGCAAAAGGCTTGAAAAAAGGCAGGGAGTTATCCCT
GATAGGTGACTTCGAGACTG

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein 2; BAP 2; TATA sequence-binding protein 2; TBP 2; TATA-box factor 2 [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MSNLPEDSLKIENIVASTKVNDSLDLVALAAQIPGAEYNKQRFPGVVLRMQNPKIAALVFGSGKVVLTGAKSLENLTKGL
EYLVALLKELKINILDNPTYTVQNIVTSADLGSRINLNKIAMSFNLDKIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLII
TGGKKTADAKKAVKKIYDDLISLKLLQIE

Sequences:

>Translated_189_residues
MSNLPEDSLKIENIVASTKVNDSLDLVALAAQIPGAEYNKQRFPGVVLRMQNPKIAALVFGSGKVVLTGAKSLENLTKGL
EYLVALLKELKINILDNPTYTVQNIVTSADLGSRINLNKIAMSFNLDKIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLII
TGGKKTADAKKAVKKIYDDLISLKLLQIE
>Mature_188_residues
SNLPEDSLKIENIVASTKVNDSLDLVALAAQIPGAEYNKQRFPGVVLRMQNPKIAALVFGSGKVVLTGAKSLENLTKGLE
YLVALLKELKINILDNPTYTVQNIVTSADLGSRINLNKIAMSFNLDKIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLIIT
GGKKTADAKKAVKKIYDDLISLKLLQIE

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation [H]

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family [H]

Homologues:

Organism=Homo sapiens, GI285026520, Length=173, Percent_Identity=36.9942196531792, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI39930602, Length=177, Percent_Identity=36.1581920903955, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4507379, Length=173, Percent_Identity=36.9942196531792, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4759234, Length=168, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555358, Length=174, Percent_Identity=37.9310344827586, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193202769, Length=195, Percent_Identity=24.6153846153846, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17509361, Length=195, Percent_Identity=24.6153846153846, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320996, Length=168, Percent_Identity=39.8809523809524, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17136834, Length=184, Percent_Identity=35.8695652173913, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17647997, Length=177, Percent_Identity=35.5932203389831, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294 [H]

Pfam domain/function: PF00352 TBP [H]

EC number: NA

Molecular weight: Translated: 20686; Mature: 20554

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLPEDSLKIENIVASTKVNDSLDLVALAAQIPGAEYNKQRFPGVVLRMQNPKIAALVF
CCCCCCCHHHHHHHEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEE
GSGKVVLTGAKSLENLTKGLEYLVALLKELKINILDNPTYTVQNIVTSADLGSRINLNKI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEHHHHHHHCCCCCCCCCEEE
AMSFNLDKIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLIITGGKKTADAKKAVKKIYDDL
EEEECCCCEEECCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHH
ISLKLLQIE
HCEEEEEEC
>Mature Secondary Structure 
SNLPEDSLKIENIVASTKVNDSLDLVALAAQIPGAEYNKQRFPGVVLRMQNPKIAALVF
CCCCCCHHHHHHHEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEE
GSGKVVLTGAKSLENLTKGLEYLVALLKELKINILDNPTYTVQNIVTSADLGSRINLNKI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEHHHHHHHCCCCCCCCCEEE
AMSFNLDKIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLIITGGKKTADAKKAVKKIYDDL
EEEECCCCEEECCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHH
ISLKLLQIE
HCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA