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The map label for this gene is mch

Identifier: 124485226

GI number: 124485226

Start: 376067

End: 377011

Strand: Reverse

Name: mch

Synonym: Mlab_0399

Alternate gene names: 124485226

Gene position: 377011-376067 (Counterclockwise)

Preceding gene: 124485227

Following gene: 124485225

Centisome position: 20.89

GC content: 52.91

Gene sequence:

>945_bases
TTGGTAAGTGTAAACGAACTTGGACTTGATCTCTTCGAAGAACTCGTAGAGAACGCAGATCTGTTTAATGTTGCATACCA
CGAACTCGACAACGGTTCCCGTGTCGTCGACTGTGGTGTGAGTGTTCCGGGCGGCTATGGAGCCGGCGACTACTTTACCC
GTATTTGTATGGGCGGCCTTGGCGATATCGCATTCCGTCAGGGTATGGTCGGCCAGTTCCCGATGACGTTCATCGATGTG
AACACCGATTTCCCGGCAATCTCCTGCCTTGGCTCACAGAAAGCCGGATGGACTGTCAAACACGACAACTTCTTCGCCAT
GGGTTCAGGACCCGCACGTGCCCTGTCCCTTCAGCCGAAACACACCTTCGAAGTCATCGGCTACGAGGATGAGTCCGATG
CAGCAGTAATCTGTCTTGAGGCTGACCGCCTCCCAAGCGGAGCTGTCATGGAGATGATCGCAGAGAAGTGTAAGGTCGAT
GTTGCAAACGTCTGCGCTCTTGTCGCTCCGACCTCGTCACTGGTTGGTTCGATCCAGGTTGCAGGACGCTGTGTCGAGAC
TGCAGTCTACAAACTGAACGAACTCGGCTTTGACACGACGAAGATCATTGCAGCAGCAGGTACCGCCCCGATCCCGCCAG
TACGCGGAGCAAAACTCGCAATGGGCGTTACAAACGACGCAACTATCTACCACGGACAGATCAACCTGACGATGAATGCA
CCGGAGATCGTTGACTATCTTGAGAAGATCCCGAGCTGCTCGTCCAACGGATACGGCAAACCGTTCAATGATATCTTCAA
GGAAGCAGGATACGACTTCTACAAGATCGACAAGAGTCTCTTCTCCCCGGCAGAAGTTATCATCAACGAAGTTTCCACCG
GCAAAGTGTATCAGGTCGGAAAGGTCGACACCGCTGTAACCCTGAAGTCATTCGGTCTTGCATAA

Upstream 100 bases:

>100_bases
AAGCTTCTTCAGAAGAAGAACTGACAGGGAAATTCCGACTCATAACTCTTATCTATTTGACGGTTCCATATCTGACTAAT
ATTCCTTAGGGTGATTTATT

Downstream 100 bases:

>100_bases
GACGAGGAATCAGAACAGGGAATCGCTCCCACTCTTTTTCCGCAGGATTAATAACTACGTAAATAGTATTTAGTAAGGTA
ATTTGGACTCGTGGTCTAGG

Product: N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase

Products: NA

Alternate protein names: Methenyl-H4MPT cyclohydrolase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MVSVNELGLDLFEELVENADLFNVAYHELDNGSRVVDCGVSVPGGYGAGDYFTRICMGGLGDIAFRQGMVGQFPMTFIDV
NTDFPAISCLGSQKAGWTVKHDNFFAMGSGPARALSLQPKHTFEVIGYEDESDAAVICLEADRLPSGAVMEMIAEKCKVD
VANVCALVAPTSSLVGSIQVAGRCVETAVYKLNELGFDTTKIIAAAGTAPIPPVRGAKLAMGVTNDATIYHGQINLTMNA
PEIVDYLEKIPSCSSNGYGKPFNDIFKEAGYDFYKIDKSLFSPAEVIINEVSTGKVYQVGKVDTAVTLKSFGLA

Sequences:

>Translated_314_residues
MVSVNELGLDLFEELVENADLFNVAYHELDNGSRVVDCGVSVPGGYGAGDYFTRICMGGLGDIAFRQGMVGQFPMTFIDV
NTDFPAISCLGSQKAGWTVKHDNFFAMGSGPARALSLQPKHTFEVIGYEDESDAAVICLEADRLPSGAVMEMIAEKCKVD
VANVCALVAPTSSLVGSIQVAGRCVETAVYKLNELGFDTTKIIAAAGTAPIPPVRGAKLAMGVTNDATIYHGQINLTMNA
PEIVDYLEKIPSCSSNGYGKPFNDIFKEAGYDFYKIDKSLFSPAEVIINEVSTGKVYQVGKVDTAVTLKSFGLA
>Mature_314_residues
MVSVNELGLDLFEELVENADLFNVAYHELDNGSRVVDCGVSVPGGYGAGDYFTRICMGGLGDIAFRQGMVGQFPMTFIDV
NTDFPAISCLGSQKAGWTVKHDNFFAMGSGPARALSLQPKHTFEVIGYEDESDAAVICLEADRLPSGAVMEMIAEKCKVD
VANVCALVAPTSSLVGSIQVAGRCVETAVYKLNELGFDTTKIIAAAGTAPIPPVRGAKLAMGVTNDATIYHGQINLTMNA
PEIVDYLEKIPSCSSNGYGKPFNDIFKEAGYDFYKIDKSLFSPAEVIINEVSTGKVYQVGKVDTAVTLKSFGLA

Specific function: Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(+)

COG id: COG3252

COG function: function code H; Methenyltetrahydromethanopterin cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MCH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MCH_METLZ (A2SQG9)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001029842.1
- ProteinModelPortal:   A2SQG9
- SMR:   A2SQG9
- STRING:   A2SQG9
- GeneID:   4794649
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_0399
- eggNOG:   arNOG05033
- HOGENOM:   HBG497176
- OMA:   YFAMGSG
- ProtClustDB:   PRK02264
- BioCyc:   MLAB410358:MLAB_0399-MONOMER
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_00486
- InterPro:   IPR003209
- TIGRFAMs:   TIGR03120

Pfam domain/function: PF02289 MCH; SSF56199 Cyclohydrolase

EC number: =3.5.4.27

Molecular weight: Translated: 33489; Mature: 33489

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVNELGLDLFEELVENADLFNVAYHELDNGSRVVDCGVSVPGGYGAGDYFTRICMGGL
CCCHHHCCHHHHHHHHCCCCEEEHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCC
GDIAFRQGMVGQFPMTFIDVNTDFPAISCLGSQKAGWTVKHDNFFAMGSGPARALSLQPK
CHHHHHCCCCCCCCEEEEEECCCCCCEEECCCCCCCEEEECCCEEEECCCCCEEEEECCC
HTFEVIGYEDESDAAVICLEADRLPSGAVMEMIAEKCKVDVANVCALVAPTSSLVGSIQV
CEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
AGRCVETAVYKLNELGFDTTKIIAAAGTAPIPPVRGAKLAMGVTNDATIYHGQINLTMNA
HHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEEEEEECC
PEIVDYLEKIPSCSSNGYGKPFNDIFKEAGYDFYKIDKSLFSPAEVIINEVSTGKVYQVG
HHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEHHHHHCCHHHHHHHCCCCCCEEEEC
KVDTAVTLKSFGLA
CCCCEEEHHHCCCC
>Mature Secondary Structure
MVSVNELGLDLFEELVENADLFNVAYHELDNGSRVVDCGVSVPGGYGAGDYFTRICMGGL
CCCHHHCCHHHHHHHHCCCCEEEHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCC
GDIAFRQGMVGQFPMTFIDVNTDFPAISCLGSQKAGWTVKHDNFFAMGSGPARALSLQPK
CHHHHHCCCCCCCCEEEEEECCCCCCEEECCCCCCCEEEECCCEEEECCCCCEEEEECCC
HTFEVIGYEDESDAAVICLEADRLPSGAVMEMIAEKCKVDVANVCALVAPTSSLVGSIQV
CEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
AGRCVETAVYKLNELGFDTTKIIAAAGTAPIPPVRGAKLAMGVTNDATIYHGQINLTMNA
HHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEEEEEECC
PEIVDYLEKIPSCSSNGYGKPFNDIFKEAGYDFYKIDKSLFSPAEVIINEVSTGKVYQVG
HHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEHHHHHCCHHHHHHHCCCCCCEEEEC
KVDTAVTLKSFGLA
CCCCEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA