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The map label for this gene is pyrC [H]

Identifier: 124485190

GI number: 124485190

Start: 341803

End: 343068

Strand: Reverse

Name: pyrC [H]

Synonym: Mlab_0363

Alternate gene names: 124485190

Gene position: 343068-341803 (Counterclockwise)

Preceding gene: 124485191

Following gene: 124485189

Centisome position: 19.01

GC content: 52.21

Gene sequence:

>1266_bases
ATGTCTGAACTGGTTCTTTCAAATGCCCGGCTGCCTGACGGAAGGATCGCAGACATCTCCATAGATCAGGGAATCATCAC
CCACATCGGGAGTTCCGGACATGGAGAAAGAGTAATTAACTGCAGAAACCGGCTCTGCATACCGGCTGCTACCGACATGC
ATGTCCATATGCGGGATGGTAGTCAGGCAGCAAAAGAGACTTGGAAAACCGGGACTCAGGCGGCGGCGGCAGGAGGAGTG
GCTACGGTCGTCGACCAGCCAAACACCATTCCTCCAATGGATACCGTTGAAAACTTTCTGGAGAGAGCCGCTCTCGCCTC
GAAGGAATCCTTCTGTCACTTCGGCATCAACGGATCGGTTACCGAACATGCGGATATTGCAGGCCTCGCAAAAGCTGGAG
TTCTTGCATTTGGCGAGATGTTTGCAGCTCCATCGAGTTACGGCAGCGCCCTCCCTGCAGAGGTGATCAGGGATTCTCTA
AAAACCATCGCAAATCAAAACATGCTGGTCACCGTACATGCGGAAGAAGTTATTCTCGGGGAGATTCATTCCCTTGCCGA
GCATTCCCGTTCACGTCCGATATCCGGAGAGATAGAAACCATCCGGCTTGTGCAGAATCTCGCACCGACGCATGCACAAC
TGCACATCTGTCATGTCAGCGGCGCCGAAGCATTCGAAACGATCAAAGGAAGTTTCGAAGTCGCCCCCCATCATCTTTTT
TTGTCCTATGAAGATACTGATCCGGAAAATACTTTTTGGAAAATGAATCCCCCGCTCCGTTCAAAAAAGGAGCGGCTGCA
TCTCATTCAAAACTTCGCAAAAATCCCCGTGATTGCCTCGGACCATGCCCCCCATACAATTCAGGAAAAGTCACAGCCGT
TCTCCGCTTCTGCACCGTCCGGAGTTCCCGGCGTGGAAACGATGCTCCCTCTCCTGATGAATGCCGTGACACAGCGAACG
ATCACCCTGAACGATGTAATTGAAAAAACGGTAACAAATCCATGCAGAATACTTGGCATATCTGCCCCATCGCTTAGTCC
GGGCAGCCGGGCCGATCTTGCCGTATATGTCGACATCCCGACAAAGATAACCGGCGAAGCTCTGCACAGTAAATGCGGGT
GGACCCCCTATGAAGGAATGTCCGGGCTTTTTCCCGCAACAACGGTGATAGGCGGTATCCCTGCATGGCATGACGGGGAA
TTTACCCACGGCGGCGGACAGATGTGGAAAAATACCCAAAAGGCACAACTTCGCCGAAAAGAGTAA

Upstream 100 bases:

>100_bases
AGTGATTGAAGGTTCCGGGGTTGTCATGCAGACACGTATCGGCGGCGAACGATTCATCGAACCGCCGCTTGGCGATCCGG
TTCCAAGAGTTTGCTGAAAT

Downstream 100 bases:

>100_bases
TAAGCTTCAGGACAAACAAAATATGCGTGCCGAAAATACCAGACATGTTTTAGGCCCCCGTACGATCAATACGCGATCGC
GTGAAATGAGTTTCGGGACA

Product: hypothetical protein

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSELVLSNARLPDGRIADISIDQGIITHIGSSGHGERVINCRNRLCIPAATDMHVHMRDGSQAAKETWKTGTQAAAAGGV
ATVVDQPNTIPPMDTVENFLERAALASKESFCHFGINGSVTEHADIAGLAKAGVLAFGEMFAAPSSYGSALPAEVIRDSL
KTIANQNMLVTVHAEEVILGEIHSLAEHSRSRPISGEIETIRLVQNLAPTHAQLHICHVSGAEAFETIKGSFEVAPHHLF
LSYEDTDPENTFWKMNPPLRSKKERLHLIQNFAKIPVIASDHAPHTIQEKSQPFSASAPSGVPGVETMLPLLMNAVTQRT
ITLNDVIEKTVTNPCRILGISAPSLSPGSRADLAVYVDIPTKITGEALHSKCGWTPYEGMSGLFPATTVIGGIPAWHDGE
FTHGGGQMWKNTQKAQLRRKE

Sequences:

>Translated_421_residues
MSELVLSNARLPDGRIADISIDQGIITHIGSSGHGERVINCRNRLCIPAATDMHVHMRDGSQAAKETWKTGTQAAAAGGV
ATVVDQPNTIPPMDTVENFLERAALASKESFCHFGINGSVTEHADIAGLAKAGVLAFGEMFAAPSSYGSALPAEVIRDSL
KTIANQNMLVTVHAEEVILGEIHSLAEHSRSRPISGEIETIRLVQNLAPTHAQLHICHVSGAEAFETIKGSFEVAPHHLF
LSYEDTDPENTFWKMNPPLRSKKERLHLIQNFAKIPVIASDHAPHTIQEKSQPFSASAPSGVPGVETMLPLLMNAVTQRT
ITLNDVIEKTVTNPCRILGISAPSLSPGSRADLAVYVDIPTKITGEALHSKCGWTPYEGMSGLFPATTVIGGIPAWHDGE
FTHGGGQMWKNTQKAQLRRKE
>Mature_420_residues
SELVLSNARLPDGRIADISIDQGIITHIGSSGHGERVINCRNRLCIPAATDMHVHMRDGSQAAKETWKTGTQAAAAGGVA
TVVDQPNTIPPMDTVENFLERAALASKESFCHFGINGSVTEHADIAGLAKAGVLAFGEMFAAPSSYGSALPAEVIRDSLK
TIANQNMLVTVHAEEVILGEIHSLAEHSRSRPISGEIETIRLVQNLAPTHAQLHICHVSGAEAFETIKGSFEVAPHHLFL
SYEDTDPENTFWKMNPPLRSKKERLHLIQNFAKIPVIASDHAPHTIQEKSQPFSASAPSGVPGVETMLPLLMNAVTQRTI
TLNDVIEKTVTNPCRILGISAPSLSPGSRADLAVYVDIPTKITGEALHSKCGWTPYEGMSGLFPATTVIGGIPAWHDGEF
THGGGQMWKNTQKAQLRRKE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=29.639175257732, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1786722, Length=418, Percent_Identity=24.4019138755981, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87082175, Length=431, Percent_Identity=25.754060324826, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=348, Percent_Identity=30.1724137931034, Blast_Score=134, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6322218, Length=369, Percent_Identity=29.5392953929539, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24642586, Length=357, Percent_Identity=31.0924369747899, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18859883, Length=403, Percent_Identity=26.7990074441687, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45349; Mature: 45218

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELVLSNARLPDGRIADISIDQGIITHIGSSGHGERVINCRNRLCIPAATDMHVHMRDG
CCCCEECCCCCCCCCEEEEECCCCHHHHCCCCCCCCHHEECCCCEEEECCCCCEEEECCC
SQAAKETWKTGTQAAAAGGVATVVDQPNTIPPMDTVENFLERAALASKESFCHFGINGSV
CHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCC
TEHADIAGLAKAGVLAFGEMFAAPSSYGSALPAEVIRDSLKTIANQNMLVTVHAEEVILG
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHH
EIHSLAEHSRSRPISGEIETIRLVQNLAPTHAQLHICHVSGAEAFETIKGSFEVAPHHLF
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCEEECCEEEE
LSYEDTDPENTFWKMNPPLRSKKERLHLIQNFAKIPVIASDHAPHTIQEKSQPFSASAPS
EEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCHHHCCCCCCCCCCC
GVPGVETMLPLLMNAVTQRTITLNDVIEKTVTNPCRILGISAPSLSPGSRADLAVYVDIP
CCCCHHHHHHHHHHHHHHCEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEEECC
TKITGEALHSKCGWTPYEGMSGLFPATTVIGGIPAWHDGEFTHGGGQMWKNTQKAQLRRK
CCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECCCHHHHCCCHHHHHCCC
E
C
>Mature Secondary Structure 
SELVLSNARLPDGRIADISIDQGIITHIGSSGHGERVINCRNRLCIPAATDMHVHMRDG
CCCEECCCCCCCCCEEEEECCCCHHHHCCCCCCCCHHEECCCCEEEECCCCCEEEECCC
SQAAKETWKTGTQAAAAGGVATVVDQPNTIPPMDTVENFLERAALASKESFCHFGINGSV
CHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCC
TEHADIAGLAKAGVLAFGEMFAAPSSYGSALPAEVIRDSLKTIANQNMLVTVHAEEVILG
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHH
EIHSLAEHSRSRPISGEIETIRLVQNLAPTHAQLHICHVSGAEAFETIKGSFEVAPHHLF
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCEEECCEEEE
LSYEDTDPENTFWKMNPPLRSKKERLHLIQNFAKIPVIASDHAPHTIQEKSQPFSASAPS
EEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCHHHCCCCCCCCCCC
GVPGVETMLPLLMNAVTQRTITLNDVIEKTVTNPCRILGISAPSLSPGSRADLAVYVDIP
CCCCHHHHHHHHHHHHHHCEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEEECC
TKITGEALHSKCGWTPYEGMSGLFPATTVIGGIPAWHDGEFTHGGGQMWKNTQKAQLRRK
CCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECCCHHHHCCCHHHHHCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]