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The map label for this gene is 124485045

Identifier: 124485045

GI number: 124485045

Start: 207329

End: 208279

Strand: Reverse

Name: 124485045

Synonym: Mlab_0218

Alternate gene names: NA

Gene position: 208279-207329 (Counterclockwise)

Preceding gene: 124485046

Following gene: 124485044

Centisome position: 11.54

GC content: 52.68

Gene sequence:

>951_bases
TTGATTCAGCTTTCTGAAGTTATTACCCAGCTAAAAAGCCGAAATGCAAAAAGGATCGCAGTTCAGCTGCCCGAAGGGCT
GAAACGACAAGCAGCGGAGATCTCCAGAGCTCTAAAAGAGGAGGGGTTCGATGTCCTGATCAGCGGAGATGCCTGCTGGG
GAGCCTGCGATCTGAGTCTGGATGCTTTGGAGTGGGCGGATGTTCTCGTCCATGTCGGGCACACCCCGGTGACTCCGGAA
AAAAACGTCATCTATCTCCCATTCCAGCAGGACATTCCCCTTGAAATTCTGGAATCCGCCGTGCCTCAACTCAAGAAATA
TGCATCGGTCGGGGTCACAACGACGATCCAGCACGCCCATCAGACAAAGGCAATCTGCAGGTGGCTGAATGAACACGGAG
TGAACGCCGTGATCGGAGAGGGATCCTCGCGAACCCCGCTCGACGGCCAGGTTCTTGGATGTACCTATGCTTCGGCAAAA
AATGCAAACGCCGAAGCATACCTGTTCATCGGGACCGGCGTTTTTCATGCGATCGGCGTATCGCTTGCCACGAAAAAACC
AACCTTCTCTCTCGACCCGTTCGCCGACGGTATCCTGCAGGAAGTTTCTGCCGACCGTCTTTTGAGAAAACGGTTTGCTC
AGATCGAAAAGGCAAAAAGTGCGAAAACATTCGGGATCCTGCTCTCTTCCAAATCGGGTCAGGCACGCCGTGAACTTGCT
GAACGGCTTGCCACCTTGAACGAAAATGCCACGGTCATTCTGATTCGGGAGATATCCGAGATGCAGCTGAGAAATCTCGG
CTTCGATGCCTATGTGAATACAGCATGCCCGAGACTTGCTCTGGATGACCAGAGCCGGTTTCCCGTGCCGGTCCTCTCGC
CTGCCGAATTTGAGATCGTTCTTGGAAAACGCAGTTGGGACGATTATGTCATCGATGAAATTTTACCATGA

Upstream 100 bases:

>100_bases
GTGGATATTCTCTTTGTTGTGAACAGAGGATCTCCAGATATCGGCATTCCCTACAAAACACTTGTCACGATCGATGTTGA
CGAAAACGGTGTGAAGATCA

Downstream 100 bases:

>100_bases
AACTCAGACAACTTGAGATGTGCCTGCAGAAGGTACAGGGATTTCACTCGCCGGTTGCCGAACTTGAACAATATATGACG
CCTGCCCCGCTTGCAGCGAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIQLSEVITQLKSRNAKRIAVQLPEGLKRQAAEISRALKEEGFDVLISGDACWGACDLSLDALEWADVLVHVGHTPVTPE
KNVIYLPFQQDIPLEILESAVPQLKKYASVGVTTTIQHAHQTKAICRWLNEHGVNAVIGEGSSRTPLDGQVLGCTYASAK
NANAEAYLFIGTGVFHAIGVSLATKKPTFSLDPFADGILQEVSADRLLRKRFAQIEKAKSAKTFGILLSSKSGQARRELA
ERLATLNENATVILIREISEMQLRNLGFDAYVNTACPRLALDDQSRFPVPVLSPAEFEIVLGKRSWDDYVIDEILP

Sequences:

>Translated_316_residues
MIQLSEVITQLKSRNAKRIAVQLPEGLKRQAAEISRALKEEGFDVLISGDACWGACDLSLDALEWADVLVHVGHTPVTPE
KNVIYLPFQQDIPLEILESAVPQLKKYASVGVTTTIQHAHQTKAICRWLNEHGVNAVIGEGSSRTPLDGQVLGCTYASAK
NANAEAYLFIGTGVFHAIGVSLATKKPTFSLDPFADGILQEVSADRLLRKRFAQIEKAKSAKTFGILLSSKSGQARRELA
ERLATLNENATVILIREISEMQLRNLGFDAYVNTACPRLALDDQSRFPVPVLSPAEFEIVLGKRSWDDYVIDEILP
>Mature_316_residues
MIQLSEVITQLKSRNAKRIAVQLPEGLKRQAAEISRALKEEGFDVLISGDACWGACDLSLDALEWADVLVHVGHTPVTPE
KNVIYLPFQQDIPLEILESAVPQLKKYASVGVTTTIQHAHQTKAICRWLNEHGVNAVIGEGSSRTPLDGQVLGCTYASAK
NANAEAYLFIGTGVFHAIGVSLATKKPTFSLDPFADGILQEVSADRLLRKRFAQIEKAKSAKTFGILLSSKSGQARRELA
ERLATLNENATVILIREISEMQLRNLGFDAYVNTACPRLALDDQSRFPVPVLSPAEFEIVLGKRSWDDYVIDEILP

Specific function: Unknown

COG id: COG1736

COG function: function code J; Diphthamide synthase subunit DPH2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116686106, Length=331, Percent_Identity=29.3051359516616, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17552166, Length=320, Percent_Identity=28.125, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322088, Length=321, Percent_Identity=27.7258566978193, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662841, Length=323, Percent_Identity=29.7213622291022, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356957, Length=323, Percent_Identity=29.7213622291022, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016435
- InterPro:   IPR002728
- InterPro:   IPR022428 [H]

Pfam domain/function: PF01866 Diphthamide_syn [H]

EC number: NA

Molecular weight: Translated: 34691; Mature: 34691

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00024 HEMOPEXIN ; PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQLSEVITQLKSRNAKRIAVQLPEGLKRQAAEISRALKEEGFDVLISGDACWGACDLSL
CCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCH
DALEWADVLVHVGHTPVTPEKNVIYLPFQQDIPLEILESAVPQLKKYASVGVTTTIQHAH
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTKAICRWLNEHGVNAVIGEGSSRTPLDGQVLGCTYASAKNANAEAYLFIGTGVFHAIGV
HHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECHHHHHHHH
SLATKKPTFSLDPFADGILQEVSADRLLRKRFAQIEKAKSAKTFGILLSSKSGQARRELA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
ERLATLNENATVILIREISEMQLRNLGFDAYVNTACPRLALDDQSRFPVPVLSPAEFEIV
HHHHHCCCCCEEEEEECHHHHHHHHCCCHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEE
LGKRSWDDYVIDEILP
EECCCCCHHHHHHHCC
>Mature Secondary Structure
MIQLSEVITQLKSRNAKRIAVQLPEGLKRQAAEISRALKEEGFDVLISGDACWGACDLSL
CCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCH
DALEWADVLVHVGHTPVTPEKNVIYLPFQQDIPLEILESAVPQLKKYASVGVTTTIQHAH
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTKAICRWLNEHGVNAVIGEGSSRTPLDGQVLGCTYASAKNANAEAYLFIGTGVFHAIGV
HHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECHHHHHHHH
SLATKKPTFSLDPFADGILQEVSADRLLRKRFAQIEKAKSAKTFGILLSSKSGQARRELA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
ERLATLNENATVILIREISEMQLRNLGFDAYVNTACPRLALDDQSRFPVPVLSPAEFEIV
HHHHHCCCCCEEEEEECHHHHHHHHCCCHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEE
LGKRSWDDYVIDEILP
EECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]