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The map label for this gene is apt1 [H]

Identifier: 124485046

GI number: 124485046

Start: 208263

End: 208826

Strand: Reverse

Name: apt1 [H]

Synonym: Mlab_0219

Alternate gene names: 124485046

Gene position: 208826-208263 (Counterclockwise)

Preceding gene: 124485048

Following gene: 124485045

Centisome position: 11.57

GC content: 49.47

Gene sequence:

>564_bases
ATGCTTGAAATCCTCAAAGAATCCCTTCTGACATGTCCTATGGTCAAACGGGAAAAAGACGGGGTGGTCTATAATTATTT
CATCAATCCTCTGACAGACGGCATCCCGGAAGTCACGGCGGAACTTCTGCGTGATGTGACGGCGGCGATGATGGTGTCCC
TCGATCTGAAAAACGTCGATAAGATCGTGGTATCCGAGGCAATGGGAATCCACATAGGGACTGCGCTAACTCTTGCGACC
GGCATTCCCTTCGTTGTTATCAGAAAACGGGAATACCGTCTGCCGGGCGAAGTCGTCATCGGTCAGGAGACCGGATACTC
CAAAGGAACCCTCTATATGAACTGTGTGCATAAAGGCGACAGAGTCGTGATCATTGACGATGTCATCAGTACCGGCGGCA
CGATCAAAGGGATCCTCCCGGCACTGAAAATTGCCGGGGCGGAACTTGTGGATATTCTCTTTGTTGTGAACAGAGGATCT
CCAGATATCGGCATTCCCTACAAAACACTTGTCACGATCGATGTTGACGAAAACGGTGTGAAGATCATTGATTCAGCTTT
CTGA

Upstream 100 bases:

>100_bases
GCCGGAATGTATTTCATTGAAAGAGCATTAGCGGCACGAACAGAAAAACCTTGTCTCGCCGGCGTTAGACGTATTTGTAA
GAAAAGTCAACATATGAGGC

Downstream 100 bases:

>100_bases
AGTTATTACCCAGCTAAAAAGCCGAAATGCAAAAAGGATCGCAGTTCAGCTGCCCGAAGGGCTGAAACGACAAGCAGCGG
AGATCTCCAGAGCTCTAAAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT 1 [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLEILKESLLTCPMVKREKDGVVYNYFINPLTDGIPEVTAELLRDVTAAMMVSLDLKNVDKIVVSEAMGIHIGTALTLAT
GIPFVVIRKREYRLPGEVVIGQETGYSKGTLYMNCVHKGDRVVIIDDVISTGGTIKGILPALKIAGAELVDILFVVNRGS
PDIGIPYKTLVTIDVDENGVKIIDSAF

Sequences:

>Translated_187_residues
MLEILKESLLTCPMVKREKDGVVYNYFINPLTDGIPEVTAELLRDVTAAMMVSLDLKNVDKIVVSEAMGIHIGTALTLAT
GIPFVVIRKREYRLPGEVVIGQETGYSKGTLYMNCVHKGDRVVIIDDVISTGGTIKGILPALKIAGAELVDILFVVNRGS
PDIGIPYKTLVTIDVDENGVKIIDSAF
>Mature_187_residues
MLEILKESLLTCPMVKREKDGVVYNYFINPLTDGIPEVTAELLRDVTAAMMVSLDLKNVDKIVVSEAMGIHIGTALTLAT
GIPFVVIRKREYRLPGEVVIGQETGYSKGTLYMNCVHKGDRVVIIDDVISTGGTIKGILPALKIAGAELVDILFVVNRGS
PDIGIPYKTLVTIDVDENGVKIIDSAF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1786675, Length=132, Percent_Identity=32.5757575757576, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20289; Mature: 20289

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEILKESLLTCPMVKREKDGVVYNYFINPLTDGIPEVTAELLRDVTAAMMVSLDLKNVD
CHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHH
KIVVSEAMGIHIGTALTLATGIPFVVIRKREYRLPGEVVIGQETGYSKGTLYMNCVHKGD
HHHHHHHCCEEHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEECCCC
RVVIIDDVISTGGTIKGILPALKIAGAELVDILFVVNRGSPDIGIPYKTLVTIDVDENGV
EEEEEECHHCCCCCHHHHHHHHHHCCHHHEEEEEEEECCCCCCCCCEEEEEEEEECCCCE
KIIDSAF
EEEECCC
>Mature Secondary Structure
MLEILKESLLTCPMVKREKDGVVYNYFINPLTDGIPEVTAELLRDVTAAMMVSLDLKNVD
CHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHH
KIVVSEAMGIHIGTALTLATGIPFVVIRKREYRLPGEVVIGQETGYSKGTLYMNCVHKGD
HHHHHHHCCEEHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEECCCC
RVVIIDDVISTGGTIKGILPALKIAGAELVDILFVVNRGSPDIGIPYKTLVTIDVDENGV
EEEEEECHHCCCCCHHHHHHHHHHCCHHHEEEEEEEECCCCCCCCCEEEEEEEEECCCCE
KIIDSAF
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA