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The map label for this gene is recQ [H]

Identifier: 124484849

GI number: 124484849

Start: 21302

End: 22783

Strand: Reverse

Name: recQ [H]

Synonym: Mlab_0020

Alternate gene names: 124484849

Gene position: 22783-21302 (Counterclockwise)

Preceding gene: 124484850

Following gene: 124484847

Centisome position: 1.26

GC content: 53.91

Gene sequence:

>1482_bases
ATGACGAAAGGGATACAGCAGACACTGGAAAAATACTTCCACCACCAGACGTTCCGTCCTAACCAGCAGGAGATCATCGA
AAAGATCGTCAGCGGGAGGGACGTTCTCGCAGTGATGGCGACCGGCGGGGGAAAATCCCTCTGTTACCAGCTCCCGGCCC
TGATGCTTGACGGGATGACGATCGTCATCTCTCCCCTGATTGCTCTAATGAAAGATCAAGTGGACTCGCTTTCGAATCAG
GGGGTGACGGTCGAGACCTTAAACAGTCTGCAAACCTACGACGAACGACGAAGAGTCGAGCAGGATATGCGTGACGGAAA
AGTCAGGATCCTGTACGTCTCGCCGGAACGGGCAGTGACTCCGGCATTTTTTGCGACGCTTTCCGGCTGCAAGGTGGCGC
TTTTTGCCGTAGACGAGGCACACTGCATCTCGATGTGGGGTCATCAGTTCAGGCCCGAATATCGGGAGATCAAACATCTG
AGGGACAAGTTCCCGGGTGTTCCGATCGCCGCTTTTACCGCCACGGCTACTCTTCGGGTACGCGAAGATATCGTAAACGA
ACTGAGACTGAACGATCCCGCTGAATTCATCGGAAGTTTCGACCGGAGAAATCTCCGGTACTCGGTATTTGCTGAGCCGA
ATGCCCAGGTACGGATGCAGAAAATTATCAGTTACGTCACCGCCCACAAAGATGATCCGGGGATCATCTACTGCTTCTCG
CGGGCGAGTACCGAAGAACTGGCGGAGCGCCTTCGAAAGGTGCATATCATGGCAAATCCGTATCATGCCGGCCTGCCGAC
CCCGGAACGGAGCCGGGTGCAGGAAGGATTTCTCAATAACTCAATCAGGGTGATCTGTGCAACGGTGGCGTTCGGGATGG
GGATCGATAAACCTGACGTCAGATATGTGATCCATGCCCATATGCCAAAAGACATCGAGTCCTACTATCAGGAGACGGGA
CGGGCAGGGAGAGACGGAAAAGCCGGGGAGTGCCTGCTGTTCTATTCGGGCGGCGACCGGCGCAAGATAGAAAATATGCT
CGAACGTGAGTTCACCGATAAGAAAAAATCCGAGATCGCCCGGGAGAAGCTGGACCAGATGTATGCCTACTGCACGGCCA
AATCGTGCCGAAGACAGCTGCTCCTTTCCTACTTCGACGAAGAAATACAGCCCTGCGGGAACTGCGATACCTGCGGGGAC
AAAAAAATAAAGCAGAGCAAGCCGGCGGGCAGTCTCACGAAGATGATCCTTACAGGAGTGCAGGATGTGGACGGGATTCT
AACGACGCCCGAGTTCATCTCGTTCCTTCTCGGTCTCGAACGGGCAAAGACGGTAAAACTTCAGCTGAACACGCATCCGT
TGTTCGGTGCGGCGAACGGAAGGGAGAGAGAAGAGATCGAAAAGGAAGTCAGCAGTCTTCTCAAATCCGGCAGGCTCCGT
CTTGAAGGAAAAACCGTTCGAAAACTGTGCTCAGGAAATTGA

Upstream 100 bases:

>100_bases
ACCTGCTCGAATAATCCTGGTCCGGCAGCGAACGGTGTCTAAAGGAAAAGTGAATACCCCGCCGGTGCCAAAGTTAAGGA
AAGGGCACCCCAAAAAATTC

Downstream 100 bases:

>100_bases
TCTAGGTAAGCAGTCCCCGAAATTCCGCACCGGTCGTCTCGATATCGCTATTTTTCACCTGATCAACAAGACCTGCATAT
TTTTTACTCCCGGCACGTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTKGIQQTLEKYFHHQTFRPNQQEIIEKIVSGRDVLAVMATGGGKSLCYQLPALMLDGMTIVISPLIALMKDQVDSLSNQ
GVTVETLNSLQTYDERRRVEQDMRDGKVRILYVSPERAVTPAFFATLSGCKVALFAVDEAHCISMWGHQFRPEYREIKHL
RDKFPGVPIAAFTATATLRVREDIVNELRLNDPAEFIGSFDRRNLRYSVFAEPNAQVRMQKIISYVTAHKDDPGIIYCFS
RASTEELAERLRKVHIMANPYHAGLPTPERSRVQEGFLNNSIRVICATVAFGMGIDKPDVRYVIHAHMPKDIESYYQETG
RAGRDGKAGECLLFYSGGDRRKIENMLEREFTDKKKSEIAREKLDQMYAYCTAKSCRRQLLLSYFDEEIQPCGNCDTCGD
KKIKQSKPAGSLTKMILTGVQDVDGILTTPEFISFLLGLERAKTVKLQLNTHPLFGAANGREREEIEKEVSSLLKSGRLR
LEGKTVRKLCSGN

Sequences:

>Translated_493_residues
MTKGIQQTLEKYFHHQTFRPNQQEIIEKIVSGRDVLAVMATGGGKSLCYQLPALMLDGMTIVISPLIALMKDQVDSLSNQ
GVTVETLNSLQTYDERRRVEQDMRDGKVRILYVSPERAVTPAFFATLSGCKVALFAVDEAHCISMWGHQFRPEYREIKHL
RDKFPGVPIAAFTATATLRVREDIVNELRLNDPAEFIGSFDRRNLRYSVFAEPNAQVRMQKIISYVTAHKDDPGIIYCFS
RASTEELAERLRKVHIMANPYHAGLPTPERSRVQEGFLNNSIRVICATVAFGMGIDKPDVRYVIHAHMPKDIESYYQETG
RAGRDGKAGECLLFYSGGDRRKIENMLEREFTDKKKSEIAREKLDQMYAYCTAKSCRRQLLLSYFDEEIQPCGNCDTCGD
KKIKQSKPAGSLTKMILTGVQDVDGILTTPEFISFLLGLERAKTVKLQLNTHPLFGAANGREREEIEKEVSSLLKSGRLR
LEGKTVRKLCSGN
>Mature_492_residues
TKGIQQTLEKYFHHQTFRPNQQEIIEKIVSGRDVLAVMATGGGKSLCYQLPALMLDGMTIVISPLIALMKDQVDSLSNQG
VTVETLNSLQTYDERRRVEQDMRDGKVRILYVSPERAVTPAFFATLSGCKVALFAVDEAHCISMWGHQFRPEYREIKHLR
DKFPGVPIAAFTATATLRVREDIVNELRLNDPAEFIGSFDRRNLRYSVFAEPNAQVRMQKIISYVTAHKDDPGIIYCFSR
ASTEELAERLRKVHIMANPYHAGLPTPERSRVQEGFLNNSIRVICATVAFGMGIDKPDVRYVIHAHMPKDIESYYQETGR
AGRDGKAGECLLFYSGGDRRKIENMLEREFTDKKKSEIAREKLDQMYAYCTAKSCRRQLLLSYFDEEIQPCGNCDTCGDK
KIKQSKPAGSLTKMILTGVQDVDGILTTPEFISFLLGLERAKTVKLQLNTHPLFGAANGREREEIEKEVSSLLKSGRLRL
EGKTVRKLCSGN

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=506, Percent_Identity=37.1541501976285, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI14591902, Length=407, Percent_Identity=40.04914004914, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI14591904, Length=407, Percent_Identity=40.04914004914, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI148612816, Length=419, Percent_Identity=38.4248210023866, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI110735439, Length=405, Percent_Identity=39.2592592592593, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI169218196, Length=405, Percent_Identity=39.2592592592593, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI51242947, Length=391, Percent_Identity=39.1304347826087, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI51242943, Length=391, Percent_Identity=39.1304347826087, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI284005309, Length=370, Percent_Identity=37.8378378378378, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI50659095, Length=101, Percent_Identity=36.6336633663366, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI7661920, Length=361, Percent_Identity=21.8836565096953, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI188035877, Length=350, Percent_Identity=22, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI148613856, Length=358, Percent_Identity=23.7430167597765, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38201710, Length=358, Percent_Identity=23.7430167597765, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI222352149, Length=357, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI13129006, Length=112, Percent_Identity=33.0357142857143, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI55749865, Length=347, Percent_Identity=23.6311239193084, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994977, Length=401, Percent_Identity=49.8753117206983, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI87082221, Length=348, Percent_Identity=25, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71987997, Length=501, Percent_Identity=36.7265469061876, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71987993, Length=492, Percent_Identity=38.0081300813008, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI25145561, Length=415, Percent_Identity=39.7590361445783, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI32564293, Length=399, Percent_Identity=39.0977443609023, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17552866, Length=428, Percent_Identity=40.1869158878505, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17537549, Length=357, Percent_Identity=24.6498599439776, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533224, Length=340, Percent_Identity=22.6470588235294, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71987143, Length=339, Percent_Identity=21.5339233038348, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510307, Length=364, Percent_Identity=21.978021978022, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17510309, Length=364, Percent_Identity=21.978021978022, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995514, Length=364, Percent_Identity=21.978021978022, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=481, Percent_Identity=38.2536382536383, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6320041, Length=351, Percent_Identity=26.7806267806268, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324217, Length=327, Percent_Identity=25.0764525993884, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320224, Length=336, Percent_Identity=21.7261904761905, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646066, Length=495, Percent_Identity=37.1717171717172, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24664226, Length=426, Percent_Identity=39.6713615023474, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI62472181, Length=437, Percent_Identity=39.3592677345538, Blast_Score=291, Evalue=9e-79,
Organism=Drosophila melanogaster, GI24664230, Length=437, Percent_Identity=39.3592677345538, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI21358123, Length=399, Percent_Identity=36.5914786967419, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24662330, Length=338, Percent_Identity=22.7810650887574, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642822, Length=435, Percent_Identity=24.367816091954, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583281, Length=341, Percent_Identity=25.5131964809384, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583279, Length=341, Percent_Identity=25.5131964809384, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574962, Length=341, Percent_Identity=23.7536656891496, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 55736; Mature: 55605

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKGIQQTLEKYFHHQTFRPNQQEIIEKIVSGRDVLAVMATGGGKSLCYQLPALMLDGMT
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHH
IVISPLIALMKDQVDSLSNQGVTVETLNSLQTYDERRRVEQDMRDGKVRILYVSPERAVT
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
PAFFATLSGCKVALFAVDEAHCISMWGHQFRPEYREIKHLRDKFPGVPIAAFTATATLRV
HHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHH
REDIVNELRLNDPAEFIGSFDRRNLRYSVFAEPNAQVRMQKIISYVTAHKDDPGIIYCFS
HHHHHHHHCCCCHHHHHCCHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEC
RASTEELAERLRKVHIMANPYHAGLPTPERSRVQEGFLNNSIRVICATVAFGMGIDKPDV
CCCHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
RYVIHAHMPKDIESYYQETGRAGRDGKAGECLLFYSGGDRRKIENMLEREFTDKKKSEIA
EEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
REKLDQMYAYCTAKSCRRQLLLSYFDEEIQPCGNCDTCGDKKIKQSKPAGSLTKMILTGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHH
QDVDGILTTPEFISFLLGLERAKTVKLQLNTHPLFGAANGREREEIEKEVSSLLKSGRLR
HHHCCCCCCHHHHHHHHHHCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHCCCEE
LEGKTVRKLCSGN
ECCHHHHHHHCCC
>Mature Secondary Structure 
TKGIQQTLEKYFHHQTFRPNQQEIIEKIVSGRDVLAVMATGGGKSLCYQLPALMLDGMT
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHH
IVISPLIALMKDQVDSLSNQGVTVETLNSLQTYDERRRVEQDMRDGKVRILYVSPERAVT
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
PAFFATLSGCKVALFAVDEAHCISMWGHQFRPEYREIKHLRDKFPGVPIAAFTATATLRV
HHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHH
REDIVNELRLNDPAEFIGSFDRRNLRYSVFAEPNAQVRMQKIISYVTAHKDDPGIIYCFS
HHHHHHHHCCCCHHHHHCCHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEC
RASTEELAERLRKVHIMANPYHAGLPTPERSRVQEGFLNNSIRVICATVAFGMGIDKPDV
CCCHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
RYVIHAHMPKDIESYYQETGRAGRDGKAGECLLFYSGGDRRKIENMLEREFTDKKKSEIA
EEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
REKLDQMYAYCTAKSCRRQLLLSYFDEEIQPCGNCDTCGDKKIKQSKPAGSLTKMILTGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHH
QDVDGILTTPEFISFLLGLERAKTVKLQLNTHPLFGAANGREREEIEKEVSSLLKSGRLR
HHHCCCCCCHHHHHHHHHHCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHCCCEE
LEGKTVRKLCSGN
ECCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]