Click here to switch to the map view.

The map label for this gene is mptA

Identifier: 124484847

GI number: 124484847

Start: 19260

End: 20195

Strand: Reverse

Name: mptA

Synonym: Mlab_0018

Alternate gene names: 124484847

Gene position: 20195-19260 (Counterclockwise)

Preceding gene: 124484849

Following gene: 124484846

Centisome position: 1.12

GC content: 51.82

Gene sequence:

>936_bases
ATGTCATTACCAGATGTGCAGTCCACCGCCCCGGATGTGAGAATCAGCCTAACGCGTGTTGGTGTGAAAAATGTCAGAAA
ACTTGTCGAGGTCGGCAGACCCGGAAAGACCCGGCCGGCGATCTTTATATCAGAGTTTGATGTATTCGTTGATCTTCCAA
GCAGTCTGAAAGGAGCAAATCTTTCCAGAAACTTCGAAGTGATCGACGAGGTGCTCCAGCAGGCAACGAGCGGTGATGTC
AAAGGTATTGAGGATGTGTGCGGGATCGTTTCACGAAAACTTCTCGACCATCATGAATATGCTGACCGCACGGAAGTTTT
TATGAGAAGTTTCTACATGATGAACCGGGAGACACCCGTCTCGAAGACGTCATGTCAGGAAGTCATCAATGTCTACGCAC
ATGCGGTAGCCCAGAGAACGAACGGCAAACCGATGGTCAGGAAAAGTGTCGGAGCTGAAGTTACCGGTATCACCGCATGT
CCGTGCGCTCAAAACATCATGAAGGATCACGCGATGCATGTGATGGAACAACTCGAGATTCCCGAGGATAAGATCTCGGC
ATTCTTCAACGAGATCCCGATGGCAAGCCACAACCAGCGCGGACGCGGCTTCCTCTGTGTTGAGACGGACGGCGATATCA
TCGTCCCGCTCGAAAAGATCGTAACGGTTCTCAAAGAATCGATGAGCGCAAAGATCTACGAACTCCTGAAGCGCGGCGAT
GAGAGCTATGTCGTGATGGCGGCCCACAAGAACGCCAGATTCGTCGAAGACTGTGTTCGCGAGATGGCACGCAGAGTGGT
CTCCACATTTGGTGACCTTCCTGGGGACACCCACATCACGATCCGGCAGACCAATGAGGAAAGCATCCATCAGCATGACG
CTTACGCGGAGAGAAAGGCAACCCTTGCCGAACTTCGCGATGAGCTCAGCATATAA

Upstream 100 bases:

>100_bases
ACGTATAAAATTATATACCCTCATCCCCATACACATAGTTACACGTTGACGTGCCTTAAATCGAAAACGGCATACTAACG
AAAAAAGGACACGATATATA

Downstream 100 bases:

>100_bases
TCACTTTTTTTTAATCTGTTCATCCGTCTTTGTACTTAATGAAATTATTTTCATAACCAGCAGAGATAAAGTATCTGAAA
ATGACCTCTTTTCACCATAA

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSLPDVQSTAPDVRISLTRVGVKNVRKLVEVGRPGKTRPAIFISEFDVFVDLPSSLKGANLSRNFEVIDEVLQQATSGDV
KGIEDVCGIVSRKLLDHHEYADRTEVFMRSFYMMNRETPVSKTSCQEVINVYAHAVAQRTNGKPMVRKSVGAEVTGITAC
PCAQNIMKDHAMHVMEQLEIPEDKISAFFNEIPMASHNQRGRGFLCVETDGDIIVPLEKIVTVLKESMSAKIYELLKRGD
ESYVVMAAHKNARFVEDCVREMARRVVSTFGDLPGDTHITIRQTNEESIHQHDAYAERKATLAELRDELSI

Sequences:

>Translated_311_residues
MSLPDVQSTAPDVRISLTRVGVKNVRKLVEVGRPGKTRPAIFISEFDVFVDLPSSLKGANLSRNFEVIDEVLQQATSGDV
KGIEDVCGIVSRKLLDHHEYADRTEVFMRSFYMMNRETPVSKTSCQEVINVYAHAVAQRTNGKPMVRKSVGAEVTGITAC
PCAQNIMKDHAMHVMEQLEIPEDKISAFFNEIPMASHNQRGRGFLCVETDGDIIVPLEKIVTVLKESMSAKIYELLKRGD
ESYVVMAAHKNARFVEDCVREMARRVVSTFGDLPGDTHITIRQTNEESIHQHDAYAERKATLAELRDELSI
>Mature_310_residues
SLPDVQSTAPDVRISLTRVGVKNVRKLVEVGRPGKTRPAIFISEFDVFVDLPSSLKGANLSRNFEVIDEVLQQATSGDVK
GIEDVCGIVSRKLLDHHEYADRTEVFMRSFYMMNRETPVSKTSCQEVINVYAHAVAQRTNGKPMVRKSVGAEVTGITACP
CAQNIMKDHAMHVMEQLEIPEDKISAFFNEIPMASHNQRGRGFLCVETDGDIIVPLEKIVTVLKESMSAKIYELLKRGDE
SYVVMAAHKNARFVEDCVREMARRVVSTFGDLPGDTHITIRQTNEESIHQHDAYAERKATLAELRDELSI

Specific function: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MPTA_METLZ (A2SPE0)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001029463.1
- ProteinModelPortal:   A2SPE0
- SMR:   A2SPE0
- STRING:   A2SPE0
- GeneID:   4794768
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_0018
- eggNOG:   arNOG04823
- HOGENOM:   HBG626871
- OMA:   ACPCAQN
- ProtClustDB:   PRK13675
- BioCyc:   MLAB410358:MLAB_0018-MONOMER
- HAMAP:   MF_01527_A
- InterPro:   IPR003801
- InterPro:   IPR022840
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: NA

Molecular weight: Translated: 34821; Mature: 34690

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPDVQSTAPDVRISLTRVGVKNVRKLVEVGRPGKTRPAIFISEFDVFVDLPSSLKGAN
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHEEECCCCCCCCC
LSRNFEVIDEVLQQATSGDVKGIEDVCGIVSRKLLDHHEYADRTEVFMRSFYMMNRETPV
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SKTSCQEVINVYAHAVAQRTNGKPMVRKSVGAEVTGITACPCAQNIMKDHAMHVMEQLEI
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHCC
PEDKISAFFNEIPMASHNQRGRGFLCVETDGDIIVPLEKIVTVLKESMSAKIYELLKRGD
CHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHCCC
ESYVVMAAHKNARFVEDCVREMARRVVSTFGDLPGDTHITIRQTNEESIHQHDAYAERKA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
TLAELRDELSI
HHHHHHHHHCC
>Mature Secondary Structure 
SLPDVQSTAPDVRISLTRVGVKNVRKLVEVGRPGKTRPAIFISEFDVFVDLPSSLKGAN
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHEEECCCCCCCCC
LSRNFEVIDEVLQQATSGDVKGIEDVCGIVSRKLLDHHEYADRTEVFMRSFYMMNRETPV
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SKTSCQEVINVYAHAVAQRTNGKPMVRKSVGAEVTGITACPCAQNIMKDHAMHVMEQLEI
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHCC
PEDKISAFFNEIPMASHNQRGRGFLCVETDGDIIVPLEKIVTVLKESMSAKIYELLKRGD
CHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHCCC
ESYVVMAAHKNARFVEDCVREMARRVVSTFGDLPGDTHITIRQTNEESIHQHDAYAERKA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
TLAELRDELSI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA