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The map label for this gene is pccB [H]

Identifier: 124266209

GI number: 124266209

Start: 1080976

End: 1082508

Strand: Direct

Name: pccB [H]

Synonym: Mpe_A1016

Alternate gene names: 124266209

Gene position: 1080976-1082508 (Clockwise)

Preceding gene: 124266208

Following gene: 124266210

Centisome position: 26.73

GC content: 65.95

Gene sequence:

>1533_bases
ATGCACGACATCATCGAAGAGCTCAAGCGGCGACGCGAGCGGGCCCGCCTGGGCGGCGGCGAGAAGCGCATCGAGGCGCA
GCACGGCAAGGGCAAGCTCACCGCGCGCGAGCGGCTGGAGCTGTTGCTCGACGCCGGCACCTTCGAGGAATGGGACATGT
TCGTCGAGCACCGCTGCGCCGACTTCGGCATGGCCGATAACAAGATCCCCGGCGACGGCGTGGTGACCGGCTACGGCATG
ATCAACGGCCGCCTGGTGTTCGTCTTCAGCCAGGACTTCACCGTGTTCGGCGGCGCGCTCAGCGAGGCCCACGCTGAGAA
AATCTGCAAGGTGATGGACCAGGCGATGAAGGTCGGTGCGCCGGTCATCGGCTTGAACGACTCCGGCGGCGCGCGCATCC
AGGAAGGCGTGGCCTCGCTGGGCGGCTATGCCGAGGTGTTCCAGCGCAACGTGATGGCCTCGGGCGTGGTGCCGCAGATC
AGCCTGATCATGGGCCCGTCGGCTGGTGGCGCCGTCTACTCGCCGGCCATGACCGACTTCATCTTCATGGTGAAGGACAG
CAGCTACATGTTCGTCACCGGGCCCGAAGTGGTGAAGACGGTGACGCACGAGGAAGTGACGGCCGAGGAGCTGGGTGGCG
CGATCACGCACACCACCAAGAGCGGTGTCGCCGACATGGCGTTCGAGAACGACGTCGAGGCCATCCTGATGCTGCGACGC
TTCTACAACTACCTGCCGCTGAACAACCGCGAGAAGGCGCCGGTGCGCCTGGGCGGCGACCCGGCCGAGCGGCTGGACTA
TTCGCTCGACACGCTGGTGCCTGACAACGCCAACAAGCCCTACGACATGAGGGAGCTGATCCTGAAGGTGGCCGACGACG
GCGACTTCTTCGAACTCCAGCCCGAGTACGCGAAGAACATCCTGATCGGCTTCGCGCGCATGGAGGGGCAGACGGTCGGC
ATCGTCGCCAACCAGCCGCTGGTGCTGGCCGGCTGCCTGGACATCAAGAGCAGCATCAAGGCGGCGCGCTTCGTGCGCTT
CTGCGACGCCTTCAACATCCCGGTGGTCACCTTCGTCGACGTGCCGGGCTTCATGCCGGGCACCAGCCAGGAGTACGGCG
GCATCATCAAGCACGGCGCGAAGCTGCTCTACGCCTATGCCGAATGCACCGTGCCCAAGGTGACGGTGATCACCCGCAAG
GCCTACGGCGGCGCCTACGACGTGATGGCCTCCAAGCACCTGCGCGGCGACGTGAACTTCGCCTGGCCCAACGCCGAGAT
CGCGGTGATGGGCGCGAAGGGCGCGGTGGAGATCATCTTCCGCGAGGACAAGGGCGACCCGGCCAAGCTGGCCGCGCGCG
AGGCCGAGTACAAGCAGCGCTTCGCCAACCCCTTCGTGGCCGGTGCGCGCGGCTACATCGACGACGTGATCCAGCCGCAC
GAGACGCGCAAGCGCATCTGCCGTTCGCTGGTGATGCTGCGCGACAAGAAGCTCGAGAACCCGTGGCGCAAGCACGGCAA
CATTCCTCTTTGA

Upstream 100 bases:

>100_bases
GGCACGCCGCCTGCTCGACCTCGCCGACTGATTCACGCACCGACTTCTGCCCCGTTCCGTCCCACCCGACACATCCATCC
AGGCCGAGAGGACCATCCCC

Downstream 100 bases:

>100_bases
CGCGGCGAGGGAACGAGACATGTTCACCAAGATTCTTATTGCCAACCGCGGGGACAACGGCCGACAGGCCGTTGCGGCGC
AGCCAGATTGCCTGGTGCGC

Product: propionyl-CoA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MHDIIEELKRRRERARLGGGEKRIEAQHGKGKLTARERLELLLDAGTFEEWDMFVEHRCADFGMADNKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVMASGVVPQI
SLIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEAILMLRR
FYNYLPLNNREKAPVRLGGDPAERLDYSLDTLVPDNANKPYDMRELILKVADDGDFFELQPEYAKNILIGFARMEGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKVTVITRK
AYGGAYDVMASKHLRGDVNFAWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAREAEYKQRFANPFVAGARGYIDDVIQPH
ETRKRICRSLVMLRDKKLENPWRKHGNIPL

Sequences:

>Translated_510_residues
MHDIIEELKRRRERARLGGGEKRIEAQHGKGKLTARERLELLLDAGTFEEWDMFVEHRCADFGMADNKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVMASGVVPQI
SLIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEAILMLRR
FYNYLPLNNREKAPVRLGGDPAERLDYSLDTLVPDNANKPYDMRELILKVADDGDFFELQPEYAKNILIGFARMEGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKVTVITRK
AYGGAYDVMASKHLRGDVNFAWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAREAEYKQRFANPFVAGARGYIDDVIQPH
ETRKRICRSLVMLRDKKLENPWRKHGNIPL
>Mature_510_residues
MHDIIEELKRRRERARLGGGEKRIEAQHGKGKLTARERLELLLDAGTFEEWDMFVEHRCADFGMADNKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVMASGVVPQI
SLIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEAILMLRR
FYNYLPLNNREKAPVRLGGDPAERLDYSLDTLVPDNANKPYDMRELILKVADDGDFFELQPEYAKNILIGFARMEGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKVTVITRK
AYGGAYDVMASKHLRGDVNFAWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAREAEYKQRFANPFVAGARGYIDDVIQPH
ETRKRICRSLVMLRDKKLENPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=70.2169625246548, Blast_Score=748, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=67.5521821631879, Blast_Score=734, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=503, Percent_Identity=33.5984095427435, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI38679960, Length=390, Percent_Identity=23.5897435897436, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679974, Length=389, Percent_Identity=22.879177377892, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679971, Length=389, Percent_Identity=22.879177377892, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679977, Length=390, Percent_Identity=23.5897435897436, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38679967, Length=390, Percent_Identity=23.5897435897436, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI134142062, Length=400, Percent_Identity=23.25, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=26.5957446808511, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=67.258382642998, Blast_Score=736, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=67.258382642998, Blast_Score=736, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=509, Percent_Identity=33.7917485265226, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24586065, Length=523, Percent_Identity=32.5047801147228, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56116; Mature: 56116

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIIEELKRRRERARLGGGEKRIEAQHGKGKLTARERLELLLDAGTFEEWDMFVEHRCA
CHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
DFGMADNKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGA
HCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYAEVFQRNVMASGVVPQISLIMGPSAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEECCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEAILMLRR
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCHHHHHHHHHH
FYNYLPLNNREKAPVRLGGDPAERLDYSLDTLVPDNANKPYDMRELILKVADDGDFFELQ
HHHHCCCCCCCCCCEEECCCHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEC
PEYAKNILIGFARMEGQTVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVD
HHHHHHHEEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKVTVITRKAYGGAYDVMASKHLRGDVNF
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEE
AWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAREAEYKQRFANPFVAGARGYIDDVIQPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHCCCC
ETRKRICRSLVMLRDKKLENPWRKHGNIPL
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
>Mature Secondary Structure
MHDIIEELKRRRERARLGGGEKRIEAQHGKGKLTARERLELLLDAGTFEEWDMFVEHRCA
CHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
DFGMADNKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGA
HCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYAEVFQRNVMASGVVPQISLIMGPSAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEECCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEAILMLRR
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCHHHHHHHHHH
FYNYLPLNNREKAPVRLGGDPAERLDYSLDTLVPDNANKPYDMRELILKVADDGDFFELQ
HHHHCCCCCCCCCCEEECCCHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEC
PEYAKNILIGFARMEGQTVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVD
HHHHHHHEEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKVTVITRKAYGGAYDVMASKHLRGDVNF
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEE
AWPNAEIAVMGAKGAVEIIFREDKGDPAKLAAREAEYKQRFANPFVAGARGYIDDVIQPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHCCCC
ETRKRICRSLVMLRDKKLENPWRKHGNIPL
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]