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The map label for this gene is gloA [H]

Identifier: 124266126

GI number: 124266126

Start: 987952

End: 988326

Strand: Direct

Name: gloA [H]

Synonym: Mpe_A0933

Alternate gene names: 124266126

Gene position: 987952-988326 (Clockwise)

Preceding gene: 124266125

Following gene: 124266127

Centisome position: 24.43

GC content: 64.0

Gene sequence:

>375_bases
ATGATCCGGGTCCGCGAGCTCGAGCGCTCGCTGAAGTTCTACGAAGCCGTCCTCGACATGAAGGAGTCCCATCGGCTCGA
CTTCCCGGAGTTCACGCTCGTCTATCTGCGCGCCGAAGGCTGTCACTTCGAAATCGAGCTGACGCTCAACAAGGGGCGTG
AGGACGACTACACGCACGGCACGGGCTACGGCCATGTCGCGGCCGTCGTGCCGGACGCGAGCGCGAAGCGGGCGCAGGTC
GATGCGCTCGGCTATGCGCCGACCGCGGTCAAGGAGTTCAAGCGAGGCGAGGAACTGCTGGCGCGGTTCTTCTTCGTGCA
GGACCCAGACGGCTACAAGATCGAGGTGCTGGAACAGCACGGGCATTACCGCTAG

Upstream 100 bases:

>100_bases
GGAGCGAGATCGCCGGATCCGCGTGCGTCCATCGACGTCTTCGACGCGCACTCGCACCCCGCCAGTCACAGGAGTACACG
TGGCAAAGCTCATTCACACC

Downstream 100 bases:

>100_bases
CGATCGTTGCAGGCCCGGGCCGGAGGTCCGGGAACGATGCGTCGCGCGTCCGACCTCGATCAGGTCCCGCGCGGCTCGGT
GAGTTTGCTCAGCGCTGCCA

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MIRVRELERSLKFYEAVLDMKESHRLDFPEFTLVYLRAEGCHFEIELTLNKGREDDYTHGTGYGHVAAVVPDASAKRAQV
DALGYAPTAVKEFKRGEELLARFFFVQDPDGYKIEVLEQHGHYR

Sequences:

>Translated_124_residues
MIRVRELERSLKFYEAVLDMKESHRLDFPEFTLVYLRAEGCHFEIELTLNKGREDDYTHGTGYGHVAAVVPDASAKRAQV
DALGYAPTAVKEFKRGEELLARFFFVQDPDGYKIEVLEQHGHYR
>Mature_124_residues
MIRVRELERSLKFYEAVLDMKESHRLDFPEFTLVYLRAEGCHFEIELTLNKGREDDYTHGTGYGHVAAVVPDASAKRAQV
DALGYAPTAVKEFKRGEELLARFFFVQDPDGYKIEVLEQHGHYR

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Escherichia coli, GI1787940, Length=124, Percent_Identity=38.7096774193548, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 14351; Mature: 14351

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVRELERSLKFYEAVLDMKESHRLDFPEFTLVYLRAEGCHFEIELTLNKGREDDYTHG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEEEECCCCCCCCCC
TGYGHVAAVVPDASAKRAQVDALGYAPTAVKEFKRGEELLARFFFVQDPDGYKIEVLEQH
CCCCEEEEEECCCCCCCEEEHHCCCCHHHHHHHHCHHHHHHHHHEEECCCCCEEEEEECC
GHYR
CCCC
>Mature Secondary Structure
MIRVRELERSLKFYEAVLDMKESHRLDFPEFTLVYLRAEGCHFEIELTLNKGREDDYTHG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEEEECCCCCCCCCC
TGYGHVAAVVPDASAKRAQVDALGYAPTAVKEFKRGEELLARFFFVQDPDGYKIEVLEQH
CCCCEEEEEECCCCCCCEEEHHCCCCHHHHHHHHCHHHHHHHHHEEECCCCCEEEEEECC
GHYR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 9719565 [H]