Click here to switch to the map view.

The map label for this gene is pamO [H]

Identifier: 124266091

GI number: 124266091

Start: 948848

End: 950467

Strand: Direct

Name: pamO [H]

Synonym: Mpe_A0898

Alternate gene names: 124266091

Gene position: 948848-950467 (Clockwise)

Preceding gene: 124266089

Following gene: 124266093

Centisome position: 23.46

GC content: 67.65

Gene sequence:

>1620_bases
ATGTCGAATGTCCAGCAGGCAACGAAGCAGGTCGATGCCGTCGTCGTGGGCGCCGGATTCGCCGGCATGTATTCGCTCTA
CAAGCTGCGCGAGCAGGGCCTGAAGGTGCAGGTCTACGAGGCCGGCACTGGCGTCGGCGGCACCTGGTACTGGAACCGCT
ACCCGGGCGCGCGGGTCGACTCGCAGGCCTACATCTACCAGTACTGGTTCTCCAAGGAGCTGCTGGACGAGTGGAACTGG
AGCGAGCGCTTCCCCGCCCAGGACGAGACCGAGCGCTACCTCAACCACGTGGCCGACCGCTTCGACCTGCGCAAGGACAT
CCAGTTCAAGACCCGGGTGACCGCGGCGGCCTATGACGAAGCGTCCCAGCGCTGGACCATCACCACCGACGACGGCCAGT
CCGTCAGTGCGCAGTACTTCATCATGGGCACCGGCGGCCTGTCGGTGCCGATGCTGCCGGCGCTGCCGGGCATCGAGAAC
TTCAAGGGCCGCATCGTGCACACGGCGCAGTGGCCGCGCGAGGGCGTGGACCTCAAGGGCAAGCGCGTCGGCATCATCGG
CACCGGCGCGACCGGCATCCAGGTGATCCAGACCATCGCCGGCGAGGTCGGGCACCTGACGGTGTTCCAGCGCACGCCGA
ACTACACCATCCCGATGCGCAACCCGAAGTACGACGACGCGGCGCGCGCCGAGCTGCGCGCGCAGTACCCGATGCTGAAG
GAGCGCGTGCAGCGCACCTTCGCCGGCTTCGACTACGACTTCGAGGACCGCAACTTCTTCGACGTGGACCCCGCCGAGCG
CCAGCGCATCCTGCAGCGCCTGTGGGACGACGGCTCGCTGAACTTCTGGATCGGCGGCTTCCGCGAGGTGTTCTTCGACG
AGAAGGTCAACGCCGAGTTCTCCGACTTCGTGCGCCAGCGCATCCGCGAGCGCGTGAAGGACCCGAAGGTGGCCGACAAG
CTGGTGCCGCAGGACTACGGCTTCGGCACGCGCCGCGTGCCGCTGGAGACCAAGTACTACGAAGCCTTCAACCGCGACAA
CGTGCTGCTGGTCGACACCAAGGCCACGCCGATGGAGGAAGTCACCGCGAAGGGCATCCGCACCTCGGCCGGCCTGCACG
AGCTCGACATCCTGATCTGCGCCACCGGCTTCGACGCCGGCACCGGCGCGCTGACCAAGGTCGACATCCGCGGCCGCGAC
GGCGTGCTGCTGCGCGATGCCTGGGCCCAGGACGGTGTGCGCACCACCATGGGCCTGCAGGTGCACGGCTACCCGAACCT
GTTCATGACGATGGCGCCGTTCTCGCCGGCGGCGGCGTTCTGCAACGTGCCCACCTGCCTGCAGCAGCAGGTGGACTGGA
TCGCCGACTGCATCGCCTTCGTGCGCCAGCAGGGCCGCCATTCCATCGAGCCCAGCGCCGAGGCCGAGGCCAAGTGGGTG
GCCCACCACGACGAACTCGCCAACCTGACGCTGGTGCCGAAGACCAACTCCTGGTACATGGGCTCCAACGTCAAGGGCAA
GCCGCGGCGCCTGCTGGCCTATGCCGGCGGCGCGGGCACCTATCGTGCCAAGTGCGAGGAAGTCAAGGCGAGCGGCTACG
AGGGCTTCGTGACCGCCTGA

Upstream 100 bases:

>100_bases
GGGTGGGTGGGGAGCGGGTGGCCAAAACTACCTGACCGGGTGGCGGAATTTGCAATGCCGGCGGGTTCAATCGGGCCGAT
CATTTCCAGAGGAGACCCTG

Downstream 100 bases:

>100_bases
ATCGGGCCGCCGCCGGCCGGCGGCGGTGCGTTCAGTCGATCGACAGCACCACGTTGCCGATCGCGCGCCCGCTCTCGACC
AGCTCGTGCGCCTCGACGAT

Product: steroid monooxygenase

Products: NA

Alternate protein names: PAMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MSNVQQATKQVDAVVVGAGFAGMYSLYKLREQGLKVQVYEAGTGVGGTWYWNRYPGARVDSQAYIYQYWFSKELLDEWNW
SERFPAQDETERYLNHVADRFDLRKDIQFKTRVTAAAYDEASQRWTITTDDGQSVSAQYFIMGTGGLSVPMLPALPGIEN
FKGRIVHTAQWPREGVDLKGKRVGIIGTGATGIQVIQTIAGEVGHLTVFQRTPNYTIPMRNPKYDDAARAELRAQYPMLK
ERVQRTFAGFDYDFEDRNFFDVDPAERQRILQRLWDDGSLNFWIGGFREVFFDEKVNAEFSDFVRQRIRERVKDPKVADK
LVPQDYGFGTRRVPLETKYYEAFNRDNVLLVDTKATPMEEVTAKGIRTSAGLHELDILICATGFDAGTGALTKVDIRGRD
GVLLRDAWAQDGVRTTMGLQVHGYPNLFMTMAPFSPAAAFCNVPTCLQQQVDWIADCIAFVRQQGRHSIEPSAEAEAKWV
AHHDELANLTLVPKTNSWYMGSNVKGKPRRLLAYAGGAGTYRAKCEEVKASGYEGFVTA

Sequences:

>Translated_539_residues
MSNVQQATKQVDAVVVGAGFAGMYSLYKLREQGLKVQVYEAGTGVGGTWYWNRYPGARVDSQAYIYQYWFSKELLDEWNW
SERFPAQDETERYLNHVADRFDLRKDIQFKTRVTAAAYDEASQRWTITTDDGQSVSAQYFIMGTGGLSVPMLPALPGIEN
FKGRIVHTAQWPREGVDLKGKRVGIIGTGATGIQVIQTIAGEVGHLTVFQRTPNYTIPMRNPKYDDAARAELRAQYPMLK
ERVQRTFAGFDYDFEDRNFFDVDPAERQRILQRLWDDGSLNFWIGGFREVFFDEKVNAEFSDFVRQRIRERVKDPKVADK
LVPQDYGFGTRRVPLETKYYEAFNRDNVLLVDTKATPMEEVTAKGIRTSAGLHELDILICATGFDAGTGALTKVDIRGRD
GVLLRDAWAQDGVRTTMGLQVHGYPNLFMTMAPFSPAAAFCNVPTCLQQQVDWIADCIAFVRQQGRHSIEPSAEAEAKWV
AHHDELANLTLVPKTNSWYMGSNVKGKPRRLLAYAGGAGTYRAKCEEVKASGYEGFVTA
>Mature_538_residues
SNVQQATKQVDAVVVGAGFAGMYSLYKLREQGLKVQVYEAGTGVGGTWYWNRYPGARVDSQAYIYQYWFSKELLDEWNWS
ERFPAQDETERYLNHVADRFDLRKDIQFKTRVTAAAYDEASQRWTITTDDGQSVSAQYFIMGTGGLSVPMLPALPGIENF
KGRIVHTAQWPREGVDLKGKRVGIIGTGATGIQVIQTIAGEVGHLTVFQRTPNYTIPMRNPKYDDAARAELRAQYPMLKE
RVQRTFAGFDYDFEDRNFFDVDPAERQRILQRLWDDGSLNFWIGGFREVFFDEKVNAEFSDFVRQRIRERVKDPKVADKL
VPQDYGFGTRRVPLETKYYEAFNRDNVLLVDTKATPMEEVTAKGIRTSAGLHELDILICATGFDAGTGALTKVDIRGRDG
VLLRDAWAQDGVRTTMGLQVHGYPNLFMTMAPFSPAAAFCNVPTCLQQQVDWIADCIAFVRQQGRHSIEPSAEAEAKWVA
HHDELANLTLVPKTNSWYMGSNVKGKPRRLLAYAGGAGTYRAKCEEVKASGYEGFVTA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503755, Length=208, Percent_Identity=31.7307692307692, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4503759, Length=221, Percent_Identity=27.6018099547511, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4503757, Length=273, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI50541965, Length=219, Percent_Identity=26.027397260274, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI50541961, Length=219, Percent_Identity=26.027397260274, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25145785, Length=208, Percent_Identity=25.4807692307692, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922866, Length=213, Percent_Identity=26.2910798122066, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921694, Length=228, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.92 [H]

Molecular weight: Translated: 60808; Mature: 60677

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVQQATKQVDAVVVGAGFAGMYSLYKLREQGLKVQVYEAGTGVGGTWYWNRYPGARVD
CCCHHHHHHHHCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCCCC
SQAYIYQYWFSKELLDEWNWSERFPAQDETERYLNHVADRFDLRKDIQFKTRVTAAAYDE
CCEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEHHEEEHHHHHC
ASQRWTITTDDGQSVSAQYFIMGTGGLSVPMLPALPGIENFKGRIVHTAQWPREGVDLKG
CCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
KRVGIIGTGATGIQVIQTIAGEVGHLTVFQRTPNYTIPMRNPKYDDAARAELRAQYPMLK
CEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHH
ERVQRTFAGFDYDFEDRNFFDVDPAERQRILQRLWDDGSLNFWIGGFREVFFDEKVNAEF
HHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCHH
SDFVRQRIRERVKDPKVADKLVPQDYGFGTRRVPLETKYYEAFNRDNVLLVDTKATPMEE
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEECCCCHHHHHHHCCCCEEEEECCCCCHHH
VTAKGIRTSAGLHELDILICATGFDAGTGALTKVDIRGRDGVLLRDAWAQDGVRTTMGLQ
HHHHCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCEEEEECHHCCCCEEEEEEE
VHGYPNLFMTMAPFSPAAAFCNVPTCLQQQVDWIADCIAFVRQQGRHSIEPSAEAEAKWV
EECCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHE
AHHDELANLTLVPKTNSWYMGSNVKGKPRRLLAYAGGAGTYRAKCEEVKASGYEGFVTA
EECCCCCCEEEEECCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEC
>Mature Secondary Structure 
SNVQQATKQVDAVVVGAGFAGMYSLYKLREQGLKVQVYEAGTGVGGTWYWNRYPGARVD
CCHHHHHHHHCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCCCC
SQAYIYQYWFSKELLDEWNWSERFPAQDETERYLNHVADRFDLRKDIQFKTRVTAAAYDE
CCEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEHHEEEHHHHHC
ASQRWTITTDDGQSVSAQYFIMGTGGLSVPMLPALPGIENFKGRIVHTAQWPREGVDLKG
CCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
KRVGIIGTGATGIQVIQTIAGEVGHLTVFQRTPNYTIPMRNPKYDDAARAELRAQYPMLK
CEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHH
ERVQRTFAGFDYDFEDRNFFDVDPAERQRILQRLWDDGSLNFWIGGFREVFFDEKVNAEF
HHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCHH
SDFVRQRIRERVKDPKVADKLVPQDYGFGTRRVPLETKYYEAFNRDNVLLVDTKATPMEE
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEECCCCHHHHHHHCCCCEEEEECCCCCHHH
VTAKGIRTSAGLHELDILICATGFDAGTGALTKVDIRGRDGVLLRDAWAQDGVRTTMGLQ
HHHHCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCEEEEECHHCCCCEEEEEEE
VHGYPNLFMTMAPFSPAAAFCNVPTCLQQQVDWIADCIAFVRQQGRHSIEPSAEAEAKWV
EECCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHE
AHHDELANLTLVPKTNSWYMGSNVKGKPRRLLAYAGGAGTYRAKCEEVKASGYEGFVTA
EECCCCCCEEEEECCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA