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The map label for this gene is hbd [H]

Identifier: 124266093

GI number: 124266093

Start: 951638

End: 952489

Strand: Direct

Name: hbd [H]

Synonym: Mpe_A0900

Alternate gene names: 124266093

Gene position: 951638-952489 (Clockwise)

Preceding gene: 124266091

Following gene: 124266094

Centisome position: 23.53

GC content: 69.95

Gene sequence:

>852_bases
ATGAGCGGTCAAACAATCGGCGTCATCGGCGCCGGCACCATGGGCAACGGCATCGCGCAGGTGTGCGCGATGGCCGGGCT
GGACGTGACGCTGGTCGACGTGTCGGACGCGGCGGTCGCGCGCGGCCTCGCGACGCTGGGCAACAGCCTGGAGCGGCTGG
TCAAGAAGGACAAGCTGACGGCCGCGGCCAGCGCCGCGGCGCTGGCACGCGTGCGCGGCACGACCGACTACGCGGCGCTG
GCCGGGGCCGACCTCGTGATCGAGGCCGCCACCGAGAACCTGGCGCTGAAGCTGCGCATCCTGCAGCAGCTCGCCGAGGT
GGTGCGCGAGGACGCGGTGATCGCGACCAACACCTCGTCGATCAGCATCACCCAGCTGGCCGCGGCGGTGAAGGCGCCCG
AGCGCTTCGTCGGCATGCACTTCTTCAACCCGGTGCCGCTGATGGCGCTGGTGGAGGTGATCGGCGGCCTGCAGACCTCG
GACGCGACGCGCGAGCGTGCGCTGGCCTTCGTCAAGTCCATCGGCAAGACGCCGATCGCGGTGAAGAACAGCCCGGGATT
CGCGGTCAACCGCATTCTGGTGCCGATGATCAACGAGGCGATCTTCGTGCTGCAGGAGGGCCTGGCCAGCGCCGAGGACA
TCGACGCCGGCATGACGCTGGGCTGCAACCAGCCGATCGGCCCGCTGGCGCTGGCCGACCTGATCGGCCTGGACACGCTG
CTCGCGGTGATGCAGGTGTTCAGCGAGGGATTCGACGACCCGAAGTACCGGCCCGCGCCGCTGCTGAAGGAAATGGTGGC
CGCCGGCCGCCTGGGCCGCAAGAGCGGCCGCGGCTTCTACACCTACGCCTGA

Upstream 100 bases:

>100_bases
GTGCAGTGGCAAAACCCGCCAGCCCCTGCGACGCGTTCGGGCATCGATGCGCAGGCCGGCAGGGCCTACAGTGGCGGGAG
ATCATCGAAGGAGTCGCTGC

Downstream 100 bases:

>100_bases
GGGCGATCGCATGTTCCGCGCCCTGATGCTGACGCAGGTGGACCGGCGCACCCATGCCGAGCTGGTGGAGCTGGACGAGT
CGCAGTTGCCGCCCGGCGAC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSGQTIGVIGAGTMGNGIAQVCAMAGLDVTLVDVSDAAVARGLATLGNSLERLVKKDKLTAAASAAALARVRGTTDYAAL
AGADLVIEAATENLALKLRILQQLAEVVREDAVIATNTSSISITQLAAAVKAPERFVGMHFFNPVPLMALVEVIGGLQTS
DATRERALAFVKSIGKTPIAVKNSPGFAVNRILVPMINEAIFVLQEGLASAEDIDAGMTLGCNQPIGPLALADLIGLDTL
LAVMQVFSEGFDDPKYRPAPLLKEMVAAGRLGRKSGRGFYTYA

Sequences:

>Translated_283_residues
MSGQTIGVIGAGTMGNGIAQVCAMAGLDVTLVDVSDAAVARGLATLGNSLERLVKKDKLTAAASAAALARVRGTTDYAAL
AGADLVIEAATENLALKLRILQQLAEVVREDAVIATNTSSISITQLAAAVKAPERFVGMHFFNPVPLMALVEVIGGLQTS
DATRERALAFVKSIGKTPIAVKNSPGFAVNRILVPMINEAIFVLQEGLASAEDIDAGMTLGCNQPIGPLALADLIGLDTL
LAVMQVFSEGFDDPKYRPAPLLKEMVAAGRLGRKSGRGFYTYA
>Mature_282_residues
SGQTIGVIGAGTMGNGIAQVCAMAGLDVTLVDVSDAAVARGLATLGNSLERLVKKDKLTAAASAAALARVRGTTDYAALA
GADLVIEAATENLALKLRILQQLAEVVREDAVIATNTSSISITQLAAAVKAPERFVGMHFFNPVPLMALVEVIGGLQTSD
ATRERALAFVKSIGKTPIAVKNSPGFAVNRILVPMINEAIFVLQEGLASAEDIDAGMTLGCNQPIGPLALADLIGLDTLL
AVMQVFSEGFDDPKYRPAPLLKEMVAAGRLGRKSGRGFYTYA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=41.4634146341463, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=39.1447368421053, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=38.9473684210526, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=32.0819112627986, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=32.0819112627986, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI115430219, Length=250, Percent_Identity=27.6, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787661, Length=280, Percent_Identity=45.7142857142857, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=36.7424242424242, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=38.3720930232558, Blast_Score=175, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=41.6083916083916, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17553560, Length=285, Percent_Identity=41.4035087719298, Blast_Score=229, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=40.0696864111498, Blast_Score=223, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=38.5159010600707, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=38.5159010600707, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=38.5159010600707, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=36.7491166077738, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=283, Percent_Identity=31.095406360424, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=29.4326241134752, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=201, Percent_Identity=25.8706467661692, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203623, Length=201, Percent_Identity=25.8706467661692, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=40.9893992932862, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=40.9893992932862, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=40.9893992932862, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=30.3571428571429, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=29.045643153527, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29395; Mature: 29263

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQTIGVIGAGTMGNGIAQVCAMAGLDVTLVDVSDAAVARGLATLGNSLERLVKKDKLT
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
AAASAAALARVRGTTDYAALAGADLVIEAATENLALKLRILQQLAEVVREDAVIATNTSS
HHHHHHHHHHHCCCCHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
ISITQLAAAVKAPERFVGMHFFNPVPLMALVEVIGGLQTSDATRERALAFVKSIGKTPIA
CHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEE
VKNSPGFAVNRILVPMINEAIFVLQEGLASAEDIDAGMTLGCNQPIGPLALADLIGLDTL
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
LAVMQVFSEGFDDPKYRPAPLLKEMVAAGRLGRKSGRGFYTYA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
SGQTIGVIGAGTMGNGIAQVCAMAGLDVTLVDVSDAAVARGLATLGNSLERLVKKDKLT
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
AAASAAALARVRGTTDYAALAGADLVIEAATENLALKLRILQQLAEVVREDAVIATNTSS
HHHHHHHHHHHCCCCHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
ISITQLAAAVKAPERFVGMHFFNPVPLMALVEVIGGLQTSDATRERALAFVKSIGKTPIA
CHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEE
VKNSPGFAVNRILVPMINEAIFVLQEGLASAEDIDAGMTLGCNQPIGPLALADLIGLDTL
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
LAVMQVFSEGFDDPKYRPAPLLKEMVAAGRLGRKSGRGFYTYA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA