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The map label for this gene is hisI

Identifier: 124266030

GI number: 124266030

Start: 876513

End: 876902

Strand: Direct

Name: hisI

Synonym: Mpe_A0837

Alternate gene names: 124266030

Gene position: 876513-876902 (Clockwise)

Preceding gene: 124266029

Following gene: 124266031

Centisome position: 21.67

GC content: 66.41

Gene sequence:

>390_bases
ATGACTTGGCTCGATGACATTCGCTGGGACCGCGACGGCCTGCTGCCGGTGATCGCGCAGGAAGCCGCCACCGGCGACGT
GCTGATGTTCGCGTGGATGAACCGCGAGGCGCTGGCGCGCACGGCCGAACTGGGCGAGGCGGTGTACTGGAGCCGCTCGC
GCGGCAGGCTGTGGCACAAGGGCGAGGAGTCGGGCCACATCCAGAAGGTGCGCGACATGCGGCTGGACTGCGACAACGAC
GTGCTGCTGCTGAAGGTCGAACAGCTCGGCCATGAGCCCTCGATCGCCTGCCACACCGGTCGCCACAGCTGCTTCTATCA
ACGGTATGAGAGCGGCGCCTGGCACGCGGTCGAGCTGGTGCTGAAGGACCCGGAGCACATCTACAGATGA

Upstream 100 bases:

>100_bases
GGACCGGCGGAGCCGGATCCACGGCGTCCACTCGGTGGATCGTTGTTTGCCGATGGCGCCGTTCGGGAGGGGATTGCCCT
GACTCGCTAAACTGCCGGGC

Downstream 100 bases:

>100_bases
GTGGCGACGACACCCTGGCCCGTCTGGCGGCCGTGATCGAATCGCGCCGCGGCGGCGACCCCGAGGCGAGCTACGTCGCG
CGGCTGTTCCACAAGGGCAC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MTWLDDIRWDRDGLLPVIAQEAATGDVLMFAWMNREALARTAELGEAVYWSRSRGRLWHKGEESGHIQKVRDMRLDCDND
VLLLKVEQLGHEPSIACHTGRHSCFYQRYESGAWHAVELVLKDPEHIYR

Sequences:

>Translated_129_residues
MTWLDDIRWDRDGLLPVIAQEAATGDVLMFAWMNREALARTAELGEAVYWSRSRGRLWHKGEESGHIQKVRDMRLDCDND
VLLLKVEQLGHEPSIACHTGRHSCFYQRYESGAWHAVELVLKDPEHIYR
>Mature_128_residues
TWLDDIRWDRDGLLPVIAQEAATGDVLMFAWMNREALARTAELGEAVYWSRSRGRLWHKGEESGHIQKVRDMRLDCDNDV
LLLKVEQLGHEPSIACHTGRHSCFYQRYESGAWHAVELVLKDPEHIYR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=101, Percent_Identity=46.5346534653465, Blast_Score=98, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=103, Percent_Identity=37.8640776699029, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_METPP (A2SE10)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001020034.1
- STRING:   A2SE10
- GeneID:   4786972
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0837
- NMPDR:   fig|279263.3.peg.2038
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- BioCyc:   MPET420662:MPE_A0837-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15032; Mature: 14901

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWLDDIRWDRDGLLPVIAQEAATGDVLMFAWMNREALARTAELGEAVYWSRSRGRLWHK
CCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHEEECCCCCCEEC
GEESGHIQKVRDMRLDCDNDVLLLKVEQLGHEPSIACHTGRHSCFYQRYESGAWHAVELV
CCCCCCHHHHHHCCCCCCCCEEEEEHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEEEEE
LKDPEHIYR
ECCHHHHCC
>Mature Secondary Structure 
TWLDDIRWDRDGLLPVIAQEAATGDVLMFAWMNREALARTAELGEAVYWSRSRGRLWHK
CCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHEEECCCCCCEEC
GEESGHIQKVRDMRLDCDNDVLLLKVEQLGHEPSIACHTGRHSCFYQRYESGAWHAVELV
CCCCCCHHHHHHCCCCCCCCEEEEEHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEEEEE
LKDPEHIYR
ECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA