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The map label for this gene is hisE

Identifier: 124266031

GI number: 124266031

Start: 876899

End: 877261

Strand: Direct

Name: hisE

Synonym: Mpe_A0838

Alternate gene names: 124266031

Gene position: 876899-877261 (Clockwise)

Preceding gene: 124266030

Following gene: 124266032

Centisome position: 21.68

GC content: 69.7

Gene sequence:

>363_bases
ATGAGTGGCGACGACACCCTGGCCCGTCTGGCGGCCGTGATCGAATCGCGCCGCGGCGGCGACCCCGAGGCGAGCTACGT
CGCGCGGCTGTTCCACAAGGGCACCGATGCGATCCTCAAGAAAGTGGGCGAGGAAGCGACCGAGTTCGTGATGGCGGCCA
AGGACGGCGACCGCCCGAAGATCGTCGCCGAGGCGGCAGACCTGTGGTTCCACGCCATGGTGGCGCTGGCGCATTTCGGC
CTCACGCCGGCCCAGGTGCTGGCCGAGCTCGAGCGCCGCGAGGGCCAGTCGGGTCTCGAGGAGTTCGCATTGCGCAAGGT
CAGGGGCCGCGAGGCCGAGTCCACGAAGGAGAGCGGCCCATGA

Upstream 100 bases:

>100_bases
CCTGCCACACCGGTCGCCACAGCTGCTTCTATCAACGGTATGAGAGCGGCGCCTGGCACGCGGTCGAGCTGGTGCTGAAG
GACCCGGAGCACATCTACAG

Downstream 100 bases:

>100_bases
GCACGGTGATCGACAGCGACGAGCGCGAGCGCTCCCTGAAGACGGTCGGCACCGTCAGCTACCTGTTGCACCTGATCGTC
GCGGTCGGTGCGGTGCTGCC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 120; Mature: 119

Protein sequence:

>120_residues
MSGDDTLARLAAVIESRRGGDPEASYVARLFHKGTDAILKKVGEEATEFVMAAKDGDRPKIVAEAADLWFHAMVALAHFG
LTPAQVLAELERREGQSGLEEFALRKVRGREAESTKESGP

Sequences:

>Translated_120_residues
MSGDDTLARLAAVIESRRGGDPEASYVARLFHKGTDAILKKVGEEATEFVMAAKDGDRPKIVAEAADLWFHAMVALAHFG
LTPAQVLAELERREGQSGLEEFALRKVRGREAESTKESGP
>Mature_119_residues
SGDDTLARLAAVIESRRGGDPEASYVARLFHKGTDAILKKVGEEATEFVMAAKDGDRPKIVAEAADLWFHAMVALAHFGL
TPAQVLAELERREGQSGLEEFALRKVRGREAESTKESGP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=87, Percent_Identity=40.2298850574713, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_METPP (A2SE11)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001020035.1
- ProteinModelPortal:   A2SE11
- SMR:   A2SE11
- STRING:   A2SE11
- GeneID:   4786973
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0838
- NMPDR:   fig|279263.3.peg.2037
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- BioCyc:   MPET420662:MPE_A0838-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13009; Mature: 12878

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDDTLARLAAVIESRRGGDPEASYVARLFHKGTDAILKKVGEEATEFVMAAKDGDRPK
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCH
IVAEAADLWFHAMVALAHFGLTPAQVLAELERREGQSGLEEFALRKVRGREAESTKESGP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SGDDTLARLAAVIESRRGGDPEASYVARLFHKGTDAILKKVGEEATEFVMAAKDGDRPK
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCH
IVAEAADLWFHAMVALAHFGLTPAQVLAELERREGQSGLEEFALRKVRGREAESTKESGP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA