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The map label for this gene is hisD [H]

Identifier: 124266024

GI number: 124266024

Start: 871088

End: 872431

Strand: Direct

Name: hisD [H]

Synonym: Mpe_A0831

Alternate gene names: 124266024

Gene position: 871088-872431 (Clockwise)

Preceding gene: 124266023

Following gene: 124266025

Centisome position: 21.54

GC content: 71.35

Gene sequence:

>1344_bases
ATGAGCGCCCCCGCCCGCGTGAACCTGCGCCGCCTGGCCACCACGCAGCCCGATTTCGAGGCGGCATTCCGGGCCGTGCA
GCACTGGTCGGCGGAGACCGACGACGCGATCGAGGGCCGTGTGGCGGAGATCCTGGCCGACGTGCGGCAGCGCGGCGACG
CCGCGGTCCTGGAGTACACCGCGCGCTTCGACGCACTGCCGGTCGGCTCGATGGGCGAGCTCGAGCTGACGCAGGCCGAT
TTCGCCGCCGCCTTCGCGGCCATCACGCCGGCGCAGCGCGACGCGCTGCAGCAGGCCACGCGCCGCATCCGCAGCTACCA
CGAGCGCCAGCTCGACGCCTGCGGCCGCAGCTGGAGCTACCGCGACGAGGACGGCACGCTGCTGGGCCAGAAGGTCACGC
CGTTGGACCGCGTGGGCATCTACGTGCCGGGTGGCAAGGCGGCCTATCCGTCCAGCCTGCTGATGAATGCGGTGCCGGCC
CATGTGGCCGGCGTGCCCGAGATCGTGATGGTGGTGCCCACGCCGAAGGGCGAGCGCAACACCCTGGTGCTGGCCGCCGC
GCACGTGGCGGGCGTGACGCGCGCCTTCACGATCGGCGGCGCGCAGGCGGTGGCCGCACTCGCCTACGGCACGGCCACGG
TGCCGCAGGTCGACAAGATCACCGGCCCCGGCAACGCCTATGTGGCGAGCGCGAAGAAGCGCGTGTTCGGCACGGTGGGC
ATCGACATGATCGCCGGACCCAGCGAAATTCTGGTGCTGGCCGACGGCAGCACGCCGGCCGACTGGGTGGCGATGGACCT
GTTCAGCCAGGCCGAGCACGACGAGCTGGCGCAGAGCATCCTGCTGTGCCCCGATGCGGCCTATCTCGACGCAGTACAGG
CAGAGATCAACCGGCTGCTGCCCGGCATGCCGCGCGCTGCCATCATCCGCGCTTCGCTGGAAGGGCGCGGCGCGTTGATC
CACACCCGCTCGATGGAAGAGGCCTGCGAGATCAGCAACCGCATCGCGCCCGAGCACCTGGAAGTGAGCTCGAACGAGCC
GCACCGCTGGGAGCCGCTGCTGCGCCACGCCGGCGCGATCTTCCTCGGTGCCTACACCAGCGAATCGCTGGGCGACTACT
GTGCCGGGCCGAACCACGTGCTGCCGACCTCGGGCACCGCGCGCTTCAGCTCGCCGCTGGGCGTCTACGACTTCCAGAAG
CGCAGCAGCCTGATCGAGGTCAGCGAGCAGGGCGCGCAGACGCTGGGCGTGATCGCCGCCGAGCTGGCCTACGGCGAGGG
CCTGCAGGCGCACGCGCAGGCGGCCGAGATGCGGCTGGCGAAGAAGCCGAGAGCGGCACGATGA

Upstream 100 bases:

>100_bases
CGTCGCGGCTGGTGGTGAACCAGGCCGCGCTGAAGCTCAAGCGCGAGGCGATCCGTCCGCTGATCGACGCCTTCGCAGCA
GCCATCCCCCAGGAGTGAAC

Downstream 100 bases:

>100_bases
GCAGCAGCAACAGCAACAACGGCGGACCCCCGCTCGCGCCCCGCCTCGCGCGCTTCGTCCGCCAGGACGTGCAGAACATG
CACGCCTACGCGATCCAGCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSAPARVNLRRLATTQPDFEAAFRAVQHWSAETDDAIEGRVAEILADVRQRGDAAVLEYTARFDALPVGSMGELELTQAD
FAAAFAAITPAQRDALQQATRRIRSYHERQLDACGRSWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSLLMNAVPA
HVAGVPEIVMVVPTPKGERNTLVLAAAHVAGVTRAFTIGGAQAVAALAYGTATVPQVDKITGPGNAYVASAKKRVFGTVG
IDMIAGPSEILVLADGSTPADWVAMDLFSQAEHDELAQSILLCPDAAYLDAVQAEINRLLPGMPRAAIIRASLEGRGALI
HTRSMEEACEISNRIAPEHLEVSSNEPHRWEPLLRHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQK
RSSLIEVSEQGAQTLGVIAAELAYGEGLQAHAQAAEMRLAKKPRAAR

Sequences:

>Translated_447_residues
MSAPARVNLRRLATTQPDFEAAFRAVQHWSAETDDAIEGRVAEILADVRQRGDAAVLEYTARFDALPVGSMGELELTQAD
FAAAFAAITPAQRDALQQATRRIRSYHERQLDACGRSWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSLLMNAVPA
HVAGVPEIVMVVPTPKGERNTLVLAAAHVAGVTRAFTIGGAQAVAALAYGTATVPQVDKITGPGNAYVASAKKRVFGTVG
IDMIAGPSEILVLADGSTPADWVAMDLFSQAEHDELAQSILLCPDAAYLDAVQAEINRLLPGMPRAAIIRASLEGRGALI
HTRSMEEACEISNRIAPEHLEVSSNEPHRWEPLLRHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQK
RSSLIEVSEQGAQTLGVIAAELAYGEGLQAHAQAAEMRLAKKPRAAR
>Mature_446_residues
SAPARVNLRRLATTQPDFEAAFRAVQHWSAETDDAIEGRVAEILADVRQRGDAAVLEYTARFDALPVGSMGELELTQADF
AAAFAAITPAQRDALQQATRRIRSYHERQLDACGRSWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSLLMNAVPAH
VAGVPEIVMVVPTPKGERNTLVLAAAHVAGVTRAFTIGGAQAVAALAYGTATVPQVDKITGPGNAYVASAKKRVFGTVGI
DMIAGPSEILVLADGSTPADWVAMDLFSQAEHDELAQSILLCPDAAYLDAVQAEINRLLPGMPRAAIIRASLEGRGALIH
TRSMEEACEISNRIAPEHLEVSSNEPHRWEPLLRHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKR
SSLIEVSEQGAQTLGVIAAELAYGEGLQAHAQAAEMRLAKKPRAAR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=412, Percent_Identity=39.5631067961165, Blast_Score=271, Evalue=9e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=410, Percent_Identity=37.3170731707317, Blast_Score=252, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47637; Mature: 47506

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPARVNLRRLATTQPDFEAAFRAVQHWSAETDDAIEGRVAEILADVRQRGDAAVLEYT
CCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHH
ARFDALPVGSMGELELTQADFAAAFAAITPAQRDALQQATRRIRSYHERQLDACGRSWSY
HHCCCCCCCCCCCEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSLLMNAVPAHVAGVPEIVMVVPTPKGERN
CCCCCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
TLVLAAAHVAGVTRAFTIGGAQAVAALAYGTATVPQVDKITGPGNAYVASAKKRVFGTVG
EEEEEEHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHEECC
IDMIAGPSEILVLADGSTPADWVAMDLFSQAEHDELAQSILLCPDAAYLDAVQAEINRLL
HHEECCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
PGMPRAAIIRASLEGRGALIHTRSMEEACEISNRIAPEHLEVSSNEPHRWEPLLRHAGAI
CCCCHHHEEEECCCCCCEEEEECCHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHCCEE
FLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIEVSEQGAQTLGVIAA
EEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
ELAYGEGLQAHAQAAEMRLAKKPRAAR
HHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAPARVNLRRLATTQPDFEAAFRAVQHWSAETDDAIEGRVAEILADVRQRGDAAVLEYT
CCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHH
ARFDALPVGSMGELELTQADFAAAFAAITPAQRDALQQATRRIRSYHERQLDACGRSWSY
HHCCCCCCCCCCCEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSLLMNAVPAHVAGVPEIVMVVPTPKGERN
CCCCCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
TLVLAAAHVAGVTRAFTIGGAQAVAALAYGTATVPQVDKITGPGNAYVASAKKRVFGTVG
EEEEEEHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHEECC
IDMIAGPSEILVLADGSTPADWVAMDLFSQAEHDELAQSILLCPDAAYLDAVQAEINRLL
HHEECCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
PGMPRAAIIRASLEGRGALIHTRSMEEACEISNRIAPEHLEVSSNEPHRWEPLLRHAGAI
CCCCHHHEEEECCCCCCEEEEECCHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHCCEE
FLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIEVSEQGAQTLGVIAA
EEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
ELAYGEGLQAHAQAAEMRLAKKPRAAR
HHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA