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The map label for this gene is hisG

Identifier: 124266023

GI number: 124266023

Start: 870441

End: 871085

Strand: Direct

Name: hisG

Synonym: Mpe_A0830

Alternate gene names: 124266023

Gene position: 870441-871085 (Clockwise)

Preceding gene: 124266022

Following gene: 124266024

Centisome position: 21.52

GC content: 68.37

Gene sequence:

>645_bases
ATGAGCATCACGCTCGCGCTGTCGAAGGGCCGCATCTTCGAAGAGACGCTGCCGCTGCTGAAGGCGGCAGGCATCGAGGT
CACCGAGGACCCCGAGACCTCGCGCAAGCTCATCCTGCCGACCAACCGGCCCGACGTGCGCGTGGTGCTGGTGCGCGCTA
CCGACGTGCCCACCTATGTGCAGCATGGCGGCGCCGACCTCGGCGTGGTCGGGCTCGACGTGCTGCTGGAGCATGGCGGT
CAGGGCCTGTACCAGCCGCTGGACCTGCGCATCGCCAAGTGCCGCATGAGCGTGGCGGTGCGGGCCGACTTCGACTACGC
GGCGGCGGTGAAGCAGGGCTCGCGCATCCGCGTCGCCACCAAGTACGTGAGCGTCGCGCGCGACCACTTCGCCGACAAGG
GCGTGCACGTCGACCTGATCAAGCTCTACGGCTCGATGGAGCTGGCGCCGCTGACCGGCCTGGCCGATGCCATCGTCGAC
CTGGTGTCGACCGGCAGCACGCTCAAGGCCAACCACCTGCTCGAGGTCGAGCGGATCATGGACATCTCGTCGCGGCTGGT
GGTGAACCAGGCCGCGCTGAAGCTCAAGCGCGAGGCGATCCGTCCGCTGATCGACGCCTTCGCAGCAGCCATCCCCCAGG
AGTGA

Upstream 100 bases:

>100_bases
GCGGACATCGAAAGAGTGAAATGACAGTCCTCACGCGCACCTCGTTCGCTTCGCCCCGAGGGCGCGAGGCCTCCATCCGG
GCGGCCCGGCGGGAGGCCCC

Downstream 100 bases:

>100_bases
ACATGAGCGCCCCCGCCCGCGTGAACCTGCGCCGCCTGGCCACCACGCAGCCCGATTTCGAGGCGGCATTCCGGGCCGTG
CAGCACTGGTCGGCGGAGAC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSITLALSKGRIFEETLPLLKAAGIEVTEDPETSRKLILPTNRPDVRVVLVRATDVPTYVQHGGADLGVVGLDVLLEHGG
QGLYQPLDLRIAKCRMSVAVRADFDYAAAVKQGSRIRVATKYVSVARDHFADKGVHVDLIKLYGSMELAPLTGLADAIVD
LVSTGSTLKANHLLEVERIMDISSRLVVNQAALKLKREAIRPLIDAFAAAIPQE

Sequences:

>Translated_214_residues
MSITLALSKGRIFEETLPLLKAAGIEVTEDPETSRKLILPTNRPDVRVVLVRATDVPTYVQHGGADLGVVGLDVLLEHGG
QGLYQPLDLRIAKCRMSVAVRADFDYAAAVKQGSRIRVATKYVSVARDHFADKGVHVDLIKLYGSMELAPLTGLADAIVD
LVSTGSTLKANHLLEVERIMDISSRLVVNQAALKLKREAIRPLIDAFAAAIPQE
>Mature_213_residues
SITLALSKGRIFEETLPLLKAAGIEVTEDPETSRKLILPTNRPDVRVVLVRATDVPTYVQHGGADLGVVGLDVLLEHGGQ
GLYQPLDLRIAKCRMSVAVRADFDYAAAVKQGSRIRVATKYVSVARDHFADKGVHVDLIKLYGSMELAPLTGLADAIVDL
VSTGSTLKANHLLEVERIMDISSRLVVNQAALKLKREAIRPLIDAFAAAIPQE

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=218, Percent_Identity=33.0275229357798, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_METPP (A2SE03)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001020027.1
- ProteinModelPortal:   A2SE03
- SMR:   A2SE03
- STRING:   A2SE03
- GeneID:   4786965
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0830
- NMPDR:   fig|279263.3.peg.2045
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   A2SE03
- ProtClustDB:   PRK01686
- BioCyc:   MPET420662:MPE_A0830-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23186; Mature: 23055

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITLALSKGRIFEETLPLLKAAGIEVTEDPETSRKLILPTNRPDVRVVLVRATDVPTYV
CEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEEEECCCCHHH
QHGGADLGVVGLDVLLEHGGQGLYQPLDLRIAKCRMSVAVRADFDYAAAVKQGSRIRVAT
HCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEEEECCCHHHHHHCCCEEEEHH
KYVSVARDHFADKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGSTLKANHLLEVERIM
HHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DISSRLVVNQAALKLKREAIRPLIDAFAAAIPQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SITLALSKGRIFEETLPLLKAAGIEVTEDPETSRKLILPTNRPDVRVVLVRATDVPTYV
EEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEEEECCCCHHH
QHGGADLGVVGLDVLLEHGGQGLYQPLDLRIAKCRMSVAVRADFDYAAAVKQGSRIRVAT
HCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEEEECCCHHHHHHCCCEEEEHH
KYVSVARDHFADKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGSTLKANHLLEVERIM
HHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DISSRLVVNQAALKLKREAIRPLIDAFAAAIPQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA