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The map label for this gene is fdh [H]

Identifier: 124266013

GI number: 124266013

Start: 860803

End: 861864

Strand: Direct

Name: fdh [H]

Synonym: Mpe_A0820

Alternate gene names: 124266013

Gene position: 860803-861864 (Clockwise)

Preceding gene: 124266012

Following gene: 124266014

Centisome position: 21.28

GC content: 59.98

Gene sequence:

>1062_bases
ATGAAAGCCGCCGTCTATTTCGGTCCTGAGCAGATTCGACCCGTCGATATTCCGGATGCCGCCATCGGGCAAGACCACGA
AATGCTGGTCAAGGTGTCGGCCACGTCAATCTGCGGTTCCGATCTCCATCTGTATCGAGGGGCACTCGATCCGATCATGG
AGCGCGGGAAGTCCCAGACGGGGCACGAACTGATCGGCGAGGTCATTGCTGTCGGCCGCTCGGTCGGTCGCTTTCGGAAG
GGCGATCGCGTCAGCATGGCCTACTCCTGCTCCTGCGGGCATTGCTACATGTGTGAGGTGGGTCAGACTGCGCACTGCGA
AACGACGAAGAAGTCCGTATACGGCTTCGGTGTCCCCTTCGGGAATCTCAATGGCACGCACGCCGAAGCGCTGGTGATTC
CGCATGCCGATGGACATGCCATCCAGGTACCTCGACAGATTCCGGACGAAGCCGCATTGACGCTGTCATGCAACTTGCCG
TCGGCCATCATCGCCAACAAGCTGGCCGATATTCAGCCGGGTGAATCGGTGGCCCTGGTAGGGTGCGGCCCGACCGGCCT
GATGGCATTGGATATCGCACTGCAGCGTGGCCCAGGTCGTCTGGTGGTCATCGACAAGGTAGCCCACAGACTGGCGGTGG
CGCGCGTAAAGGGTGCGGTGACCGTCAATGCATCCCAGGCTGGATGGAAGGACAAGGCGCTGGCTGAATGCGACGGCCGG
GGCTTTGACAAGGTGATCGAGGTTGTGGGCTATCCCGAGACCCTGCAGATGTGCCTGGACATCGTGAGGCCAGGAGGCAC
GGTAGCCGCCGTCGGCGTCTTCACCGACAGCAACTTCAATCTCAACCTGGCCGACGTTTTCCTGCGTGACATCTCTCTGC
ACATGAACGGATTCGCCAACGTGCAACCGTTCATGTGGGAAGGACTGCGAATGATGGAGCGGGGCGTGATCAAACCTCAG
GAGTACTTCACGCACTCGTTCTCTCTCGAGGACATCGCGACAGCGTACGCGACCTTCCACACCAAGTCAGATGGCGCGAT
GAAGATGCTCATCAAGCCCTAG

Upstream 100 bases:

>100_bases
CGATCCAGGAAATGCTGATGGTTCGCTACCGAATTCCGTTCCAGCAGATCCACTTCGACAGGTACTTCTGATCGATCCCT
GAACAACGAGGAGGAAAGCG

Downstream 100 bases:

>100_bases
CGCTTCTGGCAACCAATCGACACAACAAAAATTGAAGAGGATGACAAATGAAAAAATTCGCGCTGCATGCCGTTGCCACG
GTGGCGTTGCTTGCATTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKAAVYFGPEQIRPVDIPDAAIGQDHEMLVKVSATSICGSDLHLYRGALDPIMERGKSQTGHELIGEVIAVGRSVGRFRK
GDRVSMAYSCSCGHCYMCEVGQTAHCETTKKSVYGFGVPFGNLNGTHAEALVIPHADGHAIQVPRQIPDEAALTLSCNLP
SAIIANKLADIQPGESVALVGCGPTGLMALDIALQRGPGRLVVIDKVAHRLAVARVKGAVTVNASQAGWKDKALAECDGR
GFDKVIEVVGYPETLQMCLDIVRPGGTVAAVGVFTDSNFNLNLADVFLRDISLHMNGFANVQPFMWEGLRMMERGVIKPQ
EYFTHSFSLEDIATAYATFHTKSDGAMKMLIKP

Sequences:

>Translated_353_residues
MKAAVYFGPEQIRPVDIPDAAIGQDHEMLVKVSATSICGSDLHLYRGALDPIMERGKSQTGHELIGEVIAVGRSVGRFRK
GDRVSMAYSCSCGHCYMCEVGQTAHCETTKKSVYGFGVPFGNLNGTHAEALVIPHADGHAIQVPRQIPDEAALTLSCNLP
SAIIANKLADIQPGESVALVGCGPTGLMALDIALQRGPGRLVVIDKVAHRLAVARVKGAVTVNASQAGWKDKALAECDGR
GFDKVIEVVGYPETLQMCLDIVRPGGTVAAVGVFTDSNFNLNLADVFLRDISLHMNGFANVQPFMWEGLRMMERGVIKPQ
EYFTHSFSLEDIATAYATFHTKSDGAMKMLIKP
>Mature_353_residues
MKAAVYFGPEQIRPVDIPDAAIGQDHEMLVKVSATSICGSDLHLYRGALDPIMERGKSQTGHELIGEVIAVGRSVGRFRK
GDRVSMAYSCSCGHCYMCEVGQTAHCETTKKSVYGFGVPFGNLNGTHAEALVIPHADGHAIQVPRQIPDEAALTLSCNLP
SAIIANKLADIQPGESVALVGCGPTGLMALDIALQRGPGRLVVIDKVAHRLAVARVKGAVTVNASQAGWKDKALAECDGR
GFDKVIEVVGYPETLQMCLDIVRPGGTVAAVGVFTDSNFNLNLADVFLRDISLHMNGFANVQPFMWEGLRMMERGVIKPQ
EYFTHSFSLEDIATAYATFHTKSDGAMKMLIKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=24.6575342465753, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI34577061, Length=308, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786825, Length=391, Percent_Identity=32.2250639386189, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=29.3255131964809, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=27.9329608938547, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788073, Length=360, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082125, Length=335, Percent_Identity=27.4626865671642, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI226510992, Length=315, Percent_Identity=29.5238095238095, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788075, Length=369, Percent_Identity=27.10027100271, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=26.2686567164179, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=26.3586956521739, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=295, Percent_Identity=27.7966101694915, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788407, Length=267, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=356, Percent_Identity=25.561797752809, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=27.5964391691395, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=223, Percent_Identity=30.4932735426009, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=25.3687315634218, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=334, Percent_Identity=25.4491017964072, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=24.6648793565684, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=24.5333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319258, Length=319, Percent_Identity=28.2131661442006, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=358, Percent_Identity=25.9776536312849, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=328, Percent_Identity=26.219512195122, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=26.219512195122, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=345, Percent_Identity=24.9275362318841, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=316, Percent_Identity=23.4177215189873, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=299, Percent_Identity=25.0836120401338, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=359, Percent_Identity=26.7409470752089, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737897, Length=354, Percent_Identity=25.7062146892655, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=24.1192411924119, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 37940; Mature: 37940

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVYFGPEQIRPVDIPDAAIGQDHEMLVKVSATSICGSDLHLYRGALDPIMERGKSQT
CCEEEEECCCCCCCCCCCCHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
GHELIGEVIAVGRSVGRFRKGDRVSMAYSCSCGHCYMCEVGQTAHCETTKKSVYGFGVPF
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCCCCHHHCEEEECCCC
GNLNGTHAEALVIPHADGHAIQVPRQIPDEAALTLSCNLPSAIIANKLADIQPGESVALV
CCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEE
GCGPTGLMALDIALQRGPGRLVVIDKVAHRLAVARVKGAVTVNASQAGWKDKALAECDGR
ECCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHCCCC
GFDKVIEVVGYPETLQMCLDIVRPGGTVAAVGVFTDSNFNLNLADVFLRDISLHMNGFAN
CHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCC
VQPFMWEGLRMMERGVIKPQEYFTHSFSLEDIATAYATFHTKSDGAMKMLIKP
CCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHEEEECCCCCEEEEECC
>Mature Secondary Structure
MKAAVYFGPEQIRPVDIPDAAIGQDHEMLVKVSATSICGSDLHLYRGALDPIMERGKSQT
CCEEEEECCCCCCCCCCCCHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
GHELIGEVIAVGRSVGRFRKGDRVSMAYSCSCGHCYMCEVGQTAHCETTKKSVYGFGVPF
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCCCCHHHCEEEECCCC
GNLNGTHAEALVIPHADGHAIQVPRQIPDEAALTLSCNLPSAIIANKLADIQPGESVALV
CCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEE
GCGPTGLMALDIALQRGPGRLVVIDKVAHRLAVARVKGAVTVNASQAGWKDKALAECDGR
ECCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHCCCC
GFDKVIEVVGYPETLQMCLDIVRPGGTVAAVGVFTDSNFNLNLADVFLRDISLHMNGFAN
CHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCC
VQPFMWEGLRMMERGVIKPQEYFTHSFSLEDIATAYATFHTKSDGAMKMLIKP
CCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]