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The map label for this gene is nhaA [H]

Identifier: 124265853

GI number: 124265853

Start: 694341

End: 695351

Strand: Direct

Name: nhaA [H]

Synonym: Mpe_A0660

Alternate gene names: 124265853

Gene position: 694341-695351 (Clockwise)

Preceding gene: 124265852

Following gene: 124265854

Centisome position: 17.17

GC content: 71.22

Gene sequence:

>1011_bases
ATGAGCAGTTTCGACGATCCCGCCGAGCCCACGCTGGGCCCCGCCACGCCCGCCCGCCCCGCGGCCGCCGCCGGCGGCCC
CGCGCCCACCAGCGTCGACGGGCGCGTGATCGAGGAGTTCGCGCGTGACTTCCTGAAGGAGCGCCGCAGCGAGCGGCGCT
GGCGCGCGTTGCGACGGCTCGCCTGGCTGGTGATCTTCGCGCTCATCGCCTGGGCCCTGATCACGCAGCAGCGCAATGCC
GCCGTGCCGAGCGGGCCGCACACCGCGCTGATCGAGATCCGCGGCGAGATCGCCGCAGAGGCGCTGGCAAGCGCCGAGGG
CATCAATGCCGCGCTGCGCACCGCCTTCGAGGACGCCGGCGCCCAGGCCGTGGTGCTGCGCATCAACTCGCCCGGCGGCA
GCCCGGTGCAGGCCGGCCTCGTGACCGACGAGATCAGGCGCCTGAAGGGGCTGCACGCCGACAAGAAGCTCTATGCGGTG
TGCGAGGAACTGTGTGCCTCGGCGGCCTACTACATCGCCGCGGTGGCCGACGAGATCTTCGTCGACAAGGCGTCCATCGT
CGGCTCGATCGGCGTGCTGATGGACGGCTTCGGATTCACCGGCACGATGGAGAAGCTCGGCGTCGAACGCCGCCTCATCA
CCGCCGGCGACAACAAGGGCCTGCTCGACCCCTTCTCTCCGCTGAGCGAGGCCCACAAGGCCTATGCGCAGGCGATGGTC
AACCAGATCCACCAGCAGTTCATCAAGGTGGTGAAGGACGGCCGCGGCGCGCGCCTGAAGGAGGCGCCCGAGACCTTCTC
CGGCCTGTTCTGGAGCGGCGAGTCGGCGGTGCAGCAGGGTCTGGCCGACCGGCTCGGCAGCCTGGACTACGTGGCGCGCG
AGGTGGTCAAGGCCGAAGAGGTGATCGACTACACCCCCAAGGAGAACGTGGCCGAGCGCCTGGCCAAGCGCTTCGGCGCC
GCGGTCGGCGCCGGCGCGGCCAAGGCGCTCGCGGGACCGTCGCTGCGCTGA

Upstream 100 bases:

>100_bases
TCAAGGCCGTTCGCGTGGCGGAGCGCGACGGCCAGGTGAGTTGGTATCCTTCCGCGGACATCCGGCCCGCCTTCGGCGCC
GCTTCCACACCGAGCAGTCC

Downstream 100 bases:

>100_bases
CGGCCGGAATTGCCGGCCTGTTCGGCGCTTCGACCGTCCTGCAAGTCTTCCAGAATCCTCCGAGGGCGGCGTTTGCCGCC
CGCCCCCCCGCGCACGCGCG

Product: putative protease transmembrane protein

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSSFDDPAEPTLGPATPARPAAAAGGPAPTSVDGRVIEEFARDFLKERRSERRWRALRRLAWLVIFALIAWALITQQRNA
AVPSGPHTALIEIRGEIAAEALASAEGINAALRTAFEDAGAQAVVLRINSPGGSPVQAGLVTDEIRRLKGLHADKKLYAV
CEELCASAAYYIAAVADEIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLITAGDNKGLLDPFSPLSEAHKAYAQAMV
NQIHQQFIKVVKDGRGARLKEAPETFSGLFWSGESAVQQGLADRLGSLDYVAREVVKAEEVIDYTPKENVAERLAKRFGA
AVGAGAAKALAGPSLR

Sequences:

>Translated_336_residues
MSSFDDPAEPTLGPATPARPAAAAGGPAPTSVDGRVIEEFARDFLKERRSERRWRALRRLAWLVIFALIAWALITQQRNA
AVPSGPHTALIEIRGEIAAEALASAEGINAALRTAFEDAGAQAVVLRINSPGGSPVQAGLVTDEIRRLKGLHADKKLYAV
CEELCASAAYYIAAVADEIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLITAGDNKGLLDPFSPLSEAHKAYAQAMV
NQIHQQFIKVVKDGRGARLKEAPETFSGLFWSGESAVQQGLADRLGSLDYVAREVVKAEEVIDYTPKENVAERLAKRFGA
AVGAGAAKALAGPSLR
>Mature_335_residues
SSFDDPAEPTLGPATPARPAAAAGGPAPTSVDGRVIEEFARDFLKERRSERRWRALRRLAWLVIFALIAWALITQQRNAA
VPSGPHTALIEIRGEIAAEALASAEGINAALRTAFEDAGAQAVVLRINSPGGSPVQAGLVTDEIRRLKGLHADKKLYAVC
EELCASAAYYIAAVADEIFVDKASIVGSIGVLMDGFGFTGTMEKLGVERRLITAGDNKGLLDPFSPLSEAHKAYAQAMVN
QIHQQFIKVVKDGRGARLKEAPETFSGLFWSGESAVQQGLADRLGSLDYVAREVVKAEEVIDYTPKENVAERLAKRFGAA
VGAGAAKALAGPSLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=253, Percent_Identity=28.4584980237154, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788064, Length=211, Percent_Identity=26.5402843601896, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35777; Mature: 35646

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFDDPAEPTLGPATPARPAAAAGGPAPTSVDGRVIEEFARDFLKERRSERRWRALRRL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLVIFALIAWALITQQRNAAVPSGPHTALIEIRGEIAAEALASAEGINAALRTAFEDAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQAVVLRINSPGGSPVQAGLVTDEIRRLKGLHADKKLYAVCEELCASAAYYIAAVADEIF
CEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKASIVGSIGVLMDGFGFTGTMEKLGVERRLITAGDNKGLLDPFSPLSEAHKAYAQAMV
HHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NQIHQQFIKVVKDGRGARLKEAPETFSGLFWSGESAVQQGLADRLGSLDYVAREVVKAEE
HHHHHHHHHHHHCCCCCCCHHCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
VIDYTPKENVAERLAKRFGAAVGAGAAKALAGPSLR
HHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
>Mature Secondary Structure 
SSFDDPAEPTLGPATPARPAAAAGGPAPTSVDGRVIEEFARDFLKERRSERRWRALRRL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLVIFALIAWALITQQRNAAVPSGPHTALIEIRGEIAAEALASAEGINAALRTAFEDAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQAVVLRINSPGGSPVQAGLVTDEIRRLKGLHADKKLYAVCEELCASAAYYIAAVADEIF
CEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKASIVGSIGVLMDGFGFTGTMEKLGVERRLITAGDNKGLLDPFSPLSEAHKAYAQAMV
HHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NQIHQQFIKVVKDGRGARLKEAPETFSGLFWSGESAVQQGLADRLGSLDYVAREVVKAEE
HHHHHHHHHHHHCCCCCCCHHCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
VIDYTPKENVAERLAKRFGAAVGAGAAKALAGPSLR
HHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA