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The map label for this gene is rnc [H]

Identifier: 124265843

GI number: 124265843

Start: 683767

End: 684513

Strand: Direct

Name: rnc [H]

Synonym: Mpe_A0650

Alternate gene names: 124265843

Gene position: 683767-684513 (Clockwise)

Preceding gene: 124265842

Following gene: 124265844

Centisome position: 16.91

GC content: 72.69

Gene sequence:

>747_bases
GTGCCGCGCCGCCGCCGCCAGGCGCGCGGCGCGGTCGGCGACGCCGTGAGCGACATCCCCGCCGCCTTCGACTCGCTGCA
GGTCCGTCTCGGGCACCGCTTCGCGCAGGTCGGCCTGCTGGGCCGGGCGCTGACCCACAAGAGCTTCGGCGCCGACAACA
ACGAACGGCTCGAGTTCCTCGGCGACGCGGTGTTGTCGGCCGCCATCTCGGGCCTGCTGTTCGAGCATTTCGGCCAGTCC
GGCGAGGGCGACCTGACCCGGGTGCGTGCCCACCTGGTGCGCGAGGAGATGCTGCACCGCCTGGCGCTGGATCTCGGCCT
GCCGGCCCTGCTGCGCCTGAGCGAGGGCGAGGCGCGCAGCGGCGGCGCCCGGCGTCCGTCGATCCTGGCCGACGCGGTGG
AGGCCTTGATCGCCGCGGTCTACCTCGACGGCGGCTTCGCGTCGGCGCAGGCCCTGGTCGAGCGCCTCTTCACGCCGCTG
GTCGCCAGCACCGCGGCCGAAGCCTGGACGCGCGACCCCAAGACCGAATTGCAGGAATGGCTGCAGGCCCGCCGCCAGCC
GGTGCCCGGATATCGCATCGAATCGACCCGCGGACGCCAGCATGAGCAGATGTTCACCGTGGTCTGCAGCATCCCGTCGC
GTTCGCTCGAAGTTCGCGGTGAAGGGCGGTCCCGGCGTGCCGCCGAGCAGGAGGCCGCCCGTGCGGCGCTGGCTACACTG
AAGCCAGACGAAACCGAGCGCCCATGA

Upstream 100 bases:

>100_bases
AACGAGAAGGTCGTGGTGAAGTTCGCCTACGACAAGGAGCTCGAGCTGATCCAGCCGGTCTTCCTGCTGATCAAGTACCG
GGGGCACTCGCAGTGAGGCC

Downstream 100 bases:

>100_bases
ACGACAGCACCACCGCCGCCCCTGCTGCGGGCGCAGAGATGCCCGAGCAGCGCTGCGGCCTCGTGGCGATCGTCGGCCGG
CCCAATGTCGGCAAGTCGAC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MPRRRRQARGAVGDAVSDIPAAFDSLQVRLGHRFAQVGLLGRALTHKSFGADNNERLEFLGDAVLSAAISGLLFEHFGQS
GEGDLTRVRAHLVREEMLHRLALDLGLPALLRLSEGEARSGGARRPSILADAVEALIAAVYLDGGFASAQALVERLFTPL
VASTAAEAWTRDPKTELQEWLQARRQPVPGYRIESTRGRQHEQMFTVVCSIPSRSLEVRGEGRSRRAAEQEAARAALATL
KPDETERP

Sequences:

>Translated_248_residues
MPRRRRQARGAVGDAVSDIPAAFDSLQVRLGHRFAQVGLLGRALTHKSFGADNNERLEFLGDAVLSAAISGLLFEHFGQS
GEGDLTRVRAHLVREEMLHRLALDLGLPALLRLSEGEARSGGARRPSILADAVEALIAAVYLDGGFASAQALVERLFTPL
VASTAAEAWTRDPKTELQEWLQARRQPVPGYRIESTRGRQHEQMFTVVCSIPSRSLEVRGEGRSRRAAEQEAARAALATL
KPDETERP
>Mature_247_residues
PRRRRQARGAVGDAVSDIPAAFDSLQVRLGHRFAQVGLLGRALTHKSFGADNNERLEFLGDAVLSAAISGLLFEHFGQSG
EGDLTRVRAHLVREEMLHRLALDLGLPALLRLSEGEARSGGARRPSILADAVEALIAAVYLDGGFASAQALVERLFTPLV
ASTAAEAWTRDPKTELQEWLQARRQPVPGYRIESTRGRQHEQMFTVVCSIPSRSLEVRGEGRSRRAAEQEAARAALATLK
PDETERP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=218, Percent_Identity=29.3577981651376, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI155030236, Length=218, Percent_Identity=29.3577981651376, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788920, Length=222, Percent_Identity=44.5945945945946, Blast_Score=169, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17506883, Length=233, Percent_Identity=29.1845493562232, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=233, Percent_Identity=29.1845493562232, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137682, Length=220, Percent_Identity=30.9090909090909, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27106; Mature: 26975

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRRRRQARGAVGDAVSDIPAAFDSLQVRLGHRFAQVGLLGRALTHKSFGADNNERLEFL
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GDAVLSAAISGLLFEHFGQSGEGDLTRVRAHLVREEMLHRLALDLGLPALLRLSEGEARS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCC
GGARRPSILADAVEALIAAVYLDGGFASAQALVERLFTPLVASTAAEAWTRDPKTELQEW
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LQARRQPVPGYRIESTRGRQHEQMFTVVCSIPSRSLEVRGEGRSRRAAEQEAARAALATL
HHHHCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHC
KPDETERP
CCCCCCCC
>Mature Secondary Structure 
PRRRRQARGAVGDAVSDIPAAFDSLQVRLGHRFAQVGLLGRALTHKSFGADNNERLEFL
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GDAVLSAAISGLLFEHFGQSGEGDLTRVRAHLVREEMLHRLALDLGLPALLRLSEGEARS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCC
GGARRPSILADAVEALIAAVYLDGGFASAQALVERLFTPLVASTAAEAWTRDPKTELQEW
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LQARRQPVPGYRIESTRGRQHEQMFTVVCSIPSRSLEVRGEGRSRRAAEQEAARAALATL
HHHHCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHC
KPDETERP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA