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The map label for this gene is rmlA1 [H]

Identifier: 124265819

GI number: 124265819

Start: 660447

End: 661331

Strand: Reverse

Name: rmlA1 [H]

Synonym: Mpe_A0626

Alternate gene names: 124265819

Gene position: 661331-660447 (Counterclockwise)

Preceding gene: 124265820

Following gene: 124265818

Centisome position: 16.35

GC content: 66.33

Gene sequence:

>885_bases
ATGCAACGAAAAGGCCTCATCCTCGCCGGCGGAGCCGGCACCCGGCTGCACCCGGCGACGCTGGCCATCAGCAAGCAGCT
CCTGCCGGTGTACGACAAGCCGATGGTGTATTACCCACTCACCACGCTGATGCTGGCCGGCATCCGCGACATCCTCGTCA
TCAGCACCCCGCAGGACCGCCTCAGCTTCGAAGCGCTGCTCGGCAACGGTGCGCGCTGGGGCCTGAACATCAGCTACTGC
GTGCAGCCCAGCCCCGACGGCCTGGCGCAGGCCTTCGTGCTCGGACGCGACTTCATCGCAGGCGCGCCGAGCGCCCTGGT
GCTCGGCGACAACCTCTTCCATGGCCACGATCTCCAGTCTGTGCTCGTCCGTGCCGCGCAGCGGCCGGCCGGAGCCACCG
TGTTCACCTATCACGTGCACGATCCCGAGCGCTACGGCGTGGTCGAGTTCGATGCGCAACGCCGAGCCGTCAGCATCGAG
GAAAAGCCCCGCGCCCCGAAAAGCGGCTACGCCGTGACCGGGCTGTACTTCTACGACGAGCAGGTTTGCGACATCGCCGC
CGGGCTGAAGCCTAGCGCGCGCGGCGAGTTGGAGATCACCGACATCAACACGCATTACCTGCTCGACGGCCGGCTGGACG
TGGAGATCCTGGGGCGAGGCTACGCCTGGCTCGACACCGGCACCCACGACAGCCTGCTCGACGCGGGACAATTCATCGCC
ACGCTCGAGAAGCGCCAGGGCCTGAAGGTCGCCTGCCCTGAGGAAGTGGCGTTTCGCGCAGGCTGGATCAGCGCGGAACA
ACTCGAGGCGCTGGCTGCTCCGATGCTGAAGAACAGTTATGGCCAGTACCTGCTGCGCGTGCTGCGAGAGAAGGTCTACC
GATGA

Upstream 100 bases:

>100_bases
GCGCTTCGGCCTGCGTCTTCCGCCCTGGCAGGAGGGCGTCGAGCGCCTGCTGATCGAAGTGCTGGGGCACTGACAGCAGC
GGGCCCACCCCAGAACGCCC

Downstream 100 bases:

>100_bases
AGGTGAGCCCCACGGCCCTGCCCGAGGTCTTGTTGTTCGAACCCGATATGTTTCGGGATGCACGCGGGTTCGTCGTGGAA
AGCTTCAACCAGCGTGCGTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MQRKGLILAGGAGTRLHPATLAISKQLLPVYDKPMVYYPLTTLMLAGIRDILVISTPQDRLSFEALLGNGARWGLNISYC
VQPSPDGLAQAFVLGRDFIAGAPSALVLGDNLFHGHDLQSVLVRAAQRPAGATVFTYHVHDPERYGVVEFDAQRRAVSIE
EKPRAPKSGYAVTGLYFYDEQVCDIAAGLKPSARGELEITDINTHYLLDGRLDVEILGRGYAWLDTGTHDSLLDAGQFIA
TLEKRQGLKVACPEEVAFRAGWISAEQLEALAAPMLKNSYGQYLLRVLREKVYR

Sequences:

>Translated_294_residues
MQRKGLILAGGAGTRLHPATLAISKQLLPVYDKPMVYYPLTTLMLAGIRDILVISTPQDRLSFEALLGNGARWGLNISYC
VQPSPDGLAQAFVLGRDFIAGAPSALVLGDNLFHGHDLQSVLVRAAQRPAGATVFTYHVHDPERYGVVEFDAQRRAVSIE
EKPRAPKSGYAVTGLYFYDEQVCDIAAGLKPSARGELEITDINTHYLLDGRLDVEILGRGYAWLDTGTHDSLLDAGQFIA
TLEKRQGLKVACPEEVAFRAGWISAEQLEALAAPMLKNSYGQYLLRVLREKVYR
>Mature_294_residues
MQRKGLILAGGAGTRLHPATLAISKQLLPVYDKPMVYYPLTTLMLAGIRDILVISTPQDRLSFEALLGNGARWGLNISYC
VQPSPDGLAQAFVLGRDFIAGAPSALVLGDNLFHGHDLQSVLVRAAQRPAGATVFTYHVHDPERYGVVEFDAQRRAVSIE
EKPRAPKSGYAVTGLYFYDEQVCDIAAGLKPSARGELEITDINTHYLLDGRLDVEILGRGYAWLDTGTHDSLLDAGQFIA
TLEKRQGLKVACPEEVAFRAGWISAEQLEALAAPMLKNSYGQYLLRVLREKVYR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=246, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI11761619, Length=246, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=67.3611111111111, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=60.7638888888889, Blast_Score=376, Evalue=1e-106,
Organism=Escherichia coli, GI1787488, Length=295, Percent_Identity=24.406779661017, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=28.0632411067194, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32284; Mature: 32284

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKGLILAGGAGTRLHPATLAISKQLLPVYDKPMVYYPLTTLMLAGIRDILVISTPQDR
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCHHH
LSFEALLGNGARWGLNISYCVQPSPDGLAQAFVLGRDFIAGAPSALVLGDNLFHGHDLQS
HHHHHHHCCCCEECEEEEEEECCCCCHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCHHH
VLVRAAQRPAGATVFTYHVHDPERYGVVEFDAQRRAVSIEEKPRAPKSGYAVTGLYFYDE
HHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCEECCCCCCCCCCCCEEEEEEEEECH
QVCDIAAGLKPSARGELEITDINTHYLLDGRLDVEILGRGYAWLDTGTHDSLLDAGQFIA
HHHHHHCCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCEEEEECCCCHHHHHHHHHHH
TLEKRQGLKVACPEEVAFRAGWISAEQLEALAAPMLKNSYGQYLLRVLREKVYR
HHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQRKGLILAGGAGTRLHPATLAISKQLLPVYDKPMVYYPLTTLMLAGIRDILVISTPQDR
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCHHH
LSFEALLGNGARWGLNISYCVQPSPDGLAQAFVLGRDFIAGAPSALVLGDNLFHGHDLQS
HHHHHHHCCCCEECEEEEEEECCCCCHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCHHH
VLVRAAQRPAGATVFTYHVHDPERYGVVEFDAQRRAVSIEEKPRAPKSGYAVTGLYFYDE
HHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCEECCCCCCCCCCCCEEEEEEEEECH
QVCDIAAGLKPSARGELEITDINTHYLLDGRLDVEILGRGYAWLDTGTHDSLLDAGQFIA
HHHHHHCCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCEEEEECCCCHHHHHHHHHHH
TLEKRQGLKVACPEEVAFRAGWISAEQLEALAAPMLKNSYGQYLLRVLREKVYR
HHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]