Click here to switch to the map view.

The map label for this gene is rfbD [H]

Identifier: 124265820

GI number: 124265820

Start: 661359

End: 662255

Strand: Reverse

Name: rfbD [H]

Synonym: Mpe_A0627

Alternate gene names: 124265820

Gene position: 662255-661359 (Counterclockwise)

Preceding gene: 124265821

Following gene: 124265819

Centisome position: 16.38

GC content: 70.57

Gene sequence:

>897_bases
ATGAGGATCCTGCTGCTCGGCAAGAACGGCCAGGTGGGCTGGGAGCTCCAGCGCGCGCTCGCCCCCCTCGGCGAACTGCT
CGCGCTGGCGCGCGACAGCGCGCCACTCGCGGCCGATCTCGGCTGCCCCGAGGCCTTGGTGGCGACGGTGCGCCACGTGC
GCCCGGACATCATCGTGAATGCAGCGGCCTACACCGCCGTCGACCGGGCCGAGCGCGAGCCGGCGCTCGCGCGAGCCGTC
AACGCCATCGCGCCCGCGGTGCTGGCCCGCGAGGCCGCAATGCTGGGCGCCACCTTGGTGCACTTCAGCACCGACTACGT
GTTCGACGGCTCGGGCAGCGCGCCGCGAGACGAAAGCGCCCGGACCGCCCCGATCAACGTCTATGGTGAGAGCAAGCTCG
AGGGAGAAATGGCGATCCGCGCCAGCGGCTGCCGCCACCTGATCCTGCGCTCCAGCTGGGTTCATGCGGCGCGCGGCAGC
AACTTCGCGAAGACCGTGCTGTGCCTGGCCGCCGAACGCGAGCACCTCGAGATCGTCGACGACCAGATCGGAGCTCCCAC
CGGCGCCGAGCTGCTGGCCGACGTCACCGCGCACGCCCTGTGGTCGGTTCGACAGGAACCTTCGCTCGCCGGGACTTACC
ACGTGACCGCTGGCGGCGAAACCAGTCGGCATGCCTATGCCCTTTTCGTCATCGAGCGGGCGCGCGCCCACGGTCATCCG
CTGAATGTGGCAGCCGACGCCGTCCGTCCGGTCCCCACCAGCGTCTTCCCGACACGCGCTCGGCGACCGCTCAATTCGCG
CCTCGACACCGGCAGGCTGCAATCGCGCTTCGGCCTGCGTCTTCCGCCCTGGCAGGAGGGCGTCGAGCGCCTGCTGATCG
AAGTGCTGGGGCACTGA

Upstream 100 bases:

>100_bases
AGTGGTACCTTGCTCATGCCGGCTGGGTGCGCGAGGTGCAAAGCGGCAGCTACCGCGACTGGGTGGCACAGAACTACGCC
ACGCGAACCCCAGGCCCCGC

Downstream 100 bases:

>100_bases
CAGCAGCGGGCCCACCCCAGAACGCCCATGCAACGAAAAGGCCTCATCCTCGCCGGCGGAGCCGGCACCCGGCTGCACCC
GGCGACGCTGGCCATCAGCA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRILLLGKNGQVGWELQRALAPLGELLALARDSAPLAADLGCPEALVATVRHVRPDIIVNAAAYTAVDRAEREPALARAV
NAIAPAVLAREAAMLGATLVHFSTDYVFDGSGSAPRDESARTAPINVYGESKLEGEMAIRASGCRHLILRSSWVHAARGS
NFAKTVLCLAAEREHLEIVDDQIGAPTGAELLADVTAHALWSVRQEPSLAGTYHVTAGGETSRHAYALFVIERARAHGHP
LNVAADAVRPVPTSVFPTRARRPLNSRLDTGRLQSRFGLRLPPWQEGVERLLIEVLGH

Sequences:

>Translated_298_residues
MRILLLGKNGQVGWELQRALAPLGELLALARDSAPLAADLGCPEALVATVRHVRPDIIVNAAAYTAVDRAEREPALARAV
NAIAPAVLAREAAMLGATLVHFSTDYVFDGSGSAPRDESARTAPINVYGESKLEGEMAIRASGCRHLILRSSWVHAARGS
NFAKTVLCLAAEREHLEIVDDQIGAPTGAELLADVTAHALWSVRQEPSLAGTYHVTAGGETSRHAYALFVIERARAHGHP
LNVAADAVRPVPTSVFPTRARRPLNSRLDTGRLQSRFGLRLPPWQEGVERLLIEVLGH
>Mature_298_residues
MRILLLGKNGQVGWELQRALAPLGELLALARDSAPLAADLGCPEALVATVRHVRPDIIVNAAAYTAVDRAEREPALARAV
NAIAPAVLAREAAMLGATLVHFSTDYVFDGSGSAPRDESARTAPINVYGESKLEGEMAIRASGCRHLILRSSWVHAARGS
NFAKTVLCLAAEREHLEIVDDQIGAPTGAELLADVTAHALWSVRQEPSLAGTYHVTAGGETSRHAYALFVIERARAHGHP
LNVAADAVRPVPTSVFPTRARRPLNSRLDTGRLQSRFGLRLPPWQEGVERLLIEVLGH

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=238, Percent_Identity=29.8319327731092, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI11034825, Length=238, Percent_Identity=29.8319327731092, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788352, Length=296, Percent_Identity=54.3918918918919, Blast_Score=325, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32014; Mature: 32014

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLLGKNGQVGWELQRALAPLGELLALARDSAPLAADLGCPEALVATVRHVRPDIIVN
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCCCEEE
AAAYTAVDRAEREPALARAVNAIAPAVLAREAAMLGATLVHFSTDYVFDGSGSAPRDESA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCC
RTAPINVYGESKLEGEMAIRASGCRHLILRSSWVHAARGSNFAKTVLCLAAEREHLEIVD
CCCEEEEECCCCCCCCEEEECCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHH
DQIGAPTGAELLADVTAHALWSVRQEPSLAGTYHVTAGGETSRHAYALFVIERARAHGHP
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEEEEHHHHCCCC
LNVAADAVRPVPTSVFPTRARRPLNSRLDTGRLQSRFGLRLPPWQEGVERLLIEVLGH
CCHHHHCCCCCCCCCCCHHHCCCHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRILLLGKNGQVGWELQRALAPLGELLALARDSAPLAADLGCPEALVATVRHVRPDIIVN
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCCCEEE
AAAYTAVDRAEREPALARAVNAIAPAVLAREAAMLGATLVHFSTDYVFDGSGSAPRDESA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCC
RTAPINVYGESKLEGEMAIRASGCRHLILRSSWVHAARGSNFAKTVLCLAAEREHLEIVD
CCCEEEEECCCCCCCCEEEECCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHH
DQIGAPTGAELLADVTAHALWSVRQEPSLAGTYHVTAGGETSRHAYALFVIERARAHGHP
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEEEEHHHHCCCC
LNVAADAVRPVPTSVFPTRARRPLNSRLDTGRLQSRFGLRLPPWQEGVERLLIEVLGH
CCHHHHCCCCCCCCCCCHHHCCCHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]