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The map label for this gene is hemA

Identifier: 124265717

GI number: 124265717

Start: 561490

End: 562821

Strand: Reverse

Name: hemA

Synonym: Mpe_A0524

Alternate gene names: 124265717

Gene position: 562821-561490 (Counterclockwise)

Preceding gene: 124265725

Following gene: 124265716

Centisome position: 13.92

GC content: 70.35

Gene sequence:

>1332_bases
ATGTCAGTGTTTGCCCTGGGCCTGAACCACACGACCGCGCCTGTGGATTTGCGCGGTCGTTTTGCGTTCACGCTCGAACA
ACTGGCTCCCACGCTGCAAGGCTTTCGCGAACGCCTGACCACAGGGCAGCGCCCCGGCACGCCCGAGGCCGCCATCCTCT
CGACCTGCAACCGCACCGAGCTGTATTGCGCCGCCGAGCCGCAACTGGTGCGCCCGGCGCTCGAGTGGCTAGCCGGGGTG
GGCGGCGTCGGCGCCGACACGCTGAGCCACCACGCCTACATGCTGGAGGGGGGCGAGGCGGCCCGCCACGCCTTCCGCGT
GGCCAGCGGACTGGACTCCATGGTGCTGGGCGAACCTCAGATCCTGGGTCAGATGAAGCAGGCGGTGCGCGAGGCCGACG
CCGCTGGCACCCTGGGCAGCACCTTGCACCAGCTGTTCCAGCGCAGCTTCGCGGTGGCGAAGGAAGTGCGGACGGCCACC
GAGATCGGCACCCACTCCATCAGCATGGCGGCGGCGGCCGTGCGCCTGGCCGCGCAGTTGTTCGAGGATCTGCGCGAGAT
CCGCGTGCTGTTCGTCGGCGCCGGCGAGATGATCGAGTTGGCCGCCACGCATTTCTCCGCGCGGGCACCGGCCCGCATGG
CGGTGGCCAATCGCACGTTGGAACGCGGCGAGCGACTGGCCTCGCGCTTCGGTGCCGAATCGATCCGGCTGTCGGATCTG
CCGCAGCGGCTGCACGAGTTCGACGCGGTGGTCTCCTGCACCGCCAGCTCACTGCCGCTGATCGGCCTGGGCGCGGTCGA
GCGCGCGCTGAAAGTGCGACGCCACCGCCCGATCTTCATGGTCGACCTGGCCGTGCCGCGAGACATCGAGCCCGAGGTGG
CGCGGCTCGACGACGTCTACCTGTACACCGTCGATGACCTGTCGGCCATCGTCCAGAGCGGCGGCGAGAAGCGTCTGGCT
GCCGTGGCGCAGGCCGAGGCCATCATCGAGACCGGCGTGCAGAGCTTCGTGCACTGGCTGGGTCAGCGGGGCACGGTGCC
GCTGATCCAGGCGCTGAACGCCCAGGCCGACAGCTGGCGCGAGAACGAACTGGTGCGCGCGCGCAAGCTGCTGGCCCGCG
GCGAAAGCGTCGACGCCGTGCTCGACGCGCTGTCACGCGGGCTCACGCAGAAGATGCTGCACGGCACGCTGGCCGAACTG
CACGCCTCGGACCCGGCCCAGCGTGCTCAGCTCGCCACCACAGTGTCGCGCCTGTTCCTGCGCGGGGCGATCCCGCCCGA
CGCGGTGCGGCCCAGCGGGCCCCGCGAAGACGATCATCTCGACGGGGTGTAG

Upstream 100 bases:

>100_bases
ATCAGAGCCGGGGCCGCTGGCCGTTGCAGAAGGCGCCGATGGCGCTCGGACTGCTGGTAAGTACGGCCGTTGAAGTCGAC
ATCAATTTTATAATCAGGCC

Downstream 100 bases:

>100_bases
CCCGCCGGCCGTTGCCGGCTACCGGGAGCCGCAGCGGCTGCCGGTCTGGCGCTCCCCTGCCCACCGATGAAACCCGCCCT
GCGCCTGCAACTCGACCGCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSVFALGLNHTTAPVDLRGRFAFTLEQLAPTLQGFRERLTTGQRPGTPEAAILSTCNRTELYCAAEPQLVRPALEWLAGV
GGVGADTLSHHAYMLEGGEAARHAFRVASGLDSMVLGEPQILGQMKQAVREADAAGTLGSTLHQLFQRSFAVAKEVRTAT
EIGTHSISMAAAAVRLAAQLFEDLREIRVLFVGAGEMIELAATHFSARAPARMAVANRTLERGERLASRFGAESIRLSDL
PQRLHEFDAVVSCTASSLPLIGLGAVERALKVRRHRPIFMVDLAVPRDIEPEVARLDDVYLYTVDDLSAIVQSGGEKRLA
AVAQAEAIIETGVQSFVHWLGQRGTVPLIQALNAQADSWRENELVRARKLLARGESVDAVLDALSRGLTQKMLHGTLAEL
HASDPAQRAQLATTVSRLFLRGAIPPDAVRPSGPREDDHLDGV

Sequences:

>Translated_443_residues
MSVFALGLNHTTAPVDLRGRFAFTLEQLAPTLQGFRERLTTGQRPGTPEAAILSTCNRTELYCAAEPQLVRPALEWLAGV
GGVGADTLSHHAYMLEGGEAARHAFRVASGLDSMVLGEPQILGQMKQAVREADAAGTLGSTLHQLFQRSFAVAKEVRTAT
EIGTHSISMAAAAVRLAAQLFEDLREIRVLFVGAGEMIELAATHFSARAPARMAVANRTLERGERLASRFGAESIRLSDL
PQRLHEFDAVVSCTASSLPLIGLGAVERALKVRRHRPIFMVDLAVPRDIEPEVARLDDVYLYTVDDLSAIVQSGGEKRLA
AVAQAEAIIETGVQSFVHWLGQRGTVPLIQALNAQADSWRENELVRARKLLARGESVDAVLDALSRGLTQKMLHGTLAEL
HASDPAQRAQLATTVSRLFLRGAIPPDAVRPSGPREDDHLDGV
>Mature_442_residues
SVFALGLNHTTAPVDLRGRFAFTLEQLAPTLQGFRERLTTGQRPGTPEAAILSTCNRTELYCAAEPQLVRPALEWLAGVG
GVGADTLSHHAYMLEGGEAARHAFRVASGLDSMVLGEPQILGQMKQAVREADAAGTLGSTLHQLFQRSFAVAKEVRTATE
IGTHSISMAAAAVRLAAQLFEDLREIRVLFVGAGEMIELAATHFSARAPARMAVANRTLERGERLASRFGAESIRLSDLP
QRLHEFDAVVSCTASSLPLIGLGAVERALKVRRHRPIFMVDLAVPRDIEPEVARLDDVYLYTVDDLSAIVQSGGEKRLAA
VAQAEAIIETGVQSFVHWLGQRGTVPLIQALNAQADSWRENELVRARKLLARGESVDAVLDALSRGLTQKMLHGTLAELH
ASDPAQRAQLATTVSRLFLRGAIPPDAVRPSGPREDDHLDGV

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=397, Percent_Identity=43.3249370277078, Blast_Score=311, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_METPP (A2SD47)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019721.1
- ProteinModelPortal:   A2SD47
- SMR:   A2SD47
- STRING:   A2SD47
- GeneID:   4787347
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0524
- NMPDR:   fig|279263.3.peg.2768
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   LLIDIAN
- PhylomeDB:   A2SD47
- ProtClustDB:   PRK00045
- BioCyc:   MPET420662:MPE_A0524-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47837; Mature: 47706

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 56-56 BINDING 113-113 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFALGLNHTTAPVDLRGRFAFTLEQLAPTLQGFRERLTTGQRPGTPEAAILSTCNRTE
CCEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCE
LYCAAEPQLVRPALEWLAGVGGVGADTLSHHAYMLEGGEAARHAFRVASGLDSMVLGEPQ
EEECCCCHHHHHHHHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHCCCHHHCCCHH
ILGQMKQAVREADAAGTLGSTLHQLFQRSFAVAKEVRTATEIGTHSISMAAAAVRLAAQL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FEDLREIRVLFVGAGEMIELAATHFSARAPARMAVANRTLERGERLASRFGAESIRLSDL
HHHHHHHHEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
PQRLHEFDAVVSCTASSLPLIGLGAVERALKVRRHRPIFMVDLAVPRDIEPEVARLDDVY
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEE
LYTVDDLSAIVQSGGEKRLAAVAQAEAIIETGVQSFVHWLGQRGTVPLIQALNAQADSWR
EEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
ENELVRARKLLARGESVDAVLDALSRGLTQKMLHGTLAELHASDPAQRAQLATTVSRLFL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RGAIPPDAVRPSGPREDDHLDGV
HCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVFALGLNHTTAPVDLRGRFAFTLEQLAPTLQGFRERLTTGQRPGTPEAAILSTCNRTE
CEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCE
LYCAAEPQLVRPALEWLAGVGGVGADTLSHHAYMLEGGEAARHAFRVASGLDSMVLGEPQ
EEECCCCHHHHHHHHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHCCCHHHCCCHH
ILGQMKQAVREADAAGTLGSTLHQLFQRSFAVAKEVRTATEIGTHSISMAAAAVRLAAQL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FEDLREIRVLFVGAGEMIELAATHFSARAPARMAVANRTLERGERLASRFGAESIRLSDL
HHHHHHHHEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
PQRLHEFDAVVSCTASSLPLIGLGAVERALKVRRHRPIFMVDLAVPRDIEPEVARLDDVY
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEE
LYTVDDLSAIVQSGGEKRLAAVAQAEAIIETGVQSFVHWLGQRGTVPLIQALNAQADSWR
EEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
ENELVRARKLLARGESVDAVLDALSRGLTQKMLHGTLAELHASDPAQRAQLATTVSRLFL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RGAIPPDAVRPSGPREDDHLDGV
HCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA