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The map label for this gene is sulP [C]

Identifier: 124265618

GI number: 124265618

Start: 460464

End: 462269

Strand: Reverse

Name: sulP [C]

Synonym: Mpe_A0425

Alternate gene names: 124265618

Gene position: 462269-460464 (Counterclockwise)

Preceding gene: 124265624

Following gene: 124265615

Centisome position: 11.43

GC content: 71.87

Gene sequence:

>1806_bases
ATGTCCTCACCCGCTGCGCCGGCTGCCGGCCCGCCCTGGCTACAACGCTGCTTCGGTCCGTGGGTCAGGCTCGTGTCGCG
CGAGACGCTGCGCGCCGACCTGCTGGCCGGCCTGCTGGGCGCCGTGCTGGTACTGCCTCAGGGCATCGCCTTCGCCTCGC
TCGCCGGCCTGCCGCCGCAGTACGGCCTGGCCACCGCCATCCTGCCGTGCATCGTCGCGGCGCTGTTCGGCTCCAGCCTT
CACGTGATGTCGGGGCCGACGAACGCGAACTCGCTGGCGCTGGCGGCCATGCTCACGCCGCTCGCCTGGGTGCGCAGCCC
CGACTACATCGAGCTCGCGCTGACCGTCACGCTGCTGGTCGGCGTGATGCAGACCCTGATCGGCGCGCTGCGCCTGGGCA
GCATCGCCAACTTCATCTCGCCGGCGGCCTTGCTCGGCTTCACCGCCGGCGCCTCGGTGCTGATTGCGCTGCATGCCCTG
CCCGACCTGCTGGGCATGAGTTCCGGCACCGGGTTGAGGCCGATGCTCGAGGCCCTCTGGCAGCGGCCGCTCGAGGTGGT
GCACCTCGGTTCGCTGGTCGTCGGCGTGGTGGCCCTCGCGGTCACGCTCGCCGTGCGGCACTGGCAGCGGCGCTGGCCCG
CGCTTCTGCTGGGGCTGGCGGCCGGCACGCTGGTCGCGGTGCTGCTGAACGCCGGCCATGAGGACGGCACGTTCTGGCAC
GTCGAGCAGATCGGTGAGGTGCCGCTGCCCTGGCCCCGCTGGCACTGGCCCGACATCGACATCTCGCGGCTGCGCGACCT
GGTCAGCATCGCCTTCGCCCTGACGCTGGTGGCGCTCGCCCAGTCGATCTCGATCGCCAAGGCCGTGGCCGCCCGCTCGG
GCCAGCGCATCGACGCCAACCGCGAGTTCCTCGGCCAGGGCCTGTCCAACGTGGTGGGAGGCCTGACCTCCGCCTATGTC
TCCTGCGGATCGCTGAACCGTTCGATCCCCAACCTCGAGGCCGGTGCGCGCACGCCACTGGCTTCGGTGTTCTCGGCCGG
GCTGCTGCTGTTGCTGGTGCTGGTGAGCGCCCCGCTGCTGGCGCTGATCCCGAACGCGGCGATCGCCGCGGTGCTGCTGC
CGGTCGCCTGGAACCTGCTCGACCTGCCCGGCTGGCGGCGCCTGATGCGGCTAGAACGCAGCGACTTCGCGATCGCTGCG
GCCACCGCGGTGGCCACCGTGAGCCTCAGGCTCGAGATCGCGATACTGCTCGGCAGCATCCTGTCGCTGAGCAGCTACCT
GCAACGCACGGCGCGGCCGGCCATGCGCACGATGGGGTTCGATTCCGTGGCGCCGGACCGCCCCTTCGTCGTGCTCGACG
GCCAGACCGAGGCGCTGCCGGAGTGCCCGCAGCTCAAGCTGCTGCGCATGGAGGGGGCGGTCTACTTCGGCGCCGCCCAG
CACGTGTCGGACACCCTGCACCACCTGCGCGCGGCGCCCGCCGCGCCGCGCCACCTGCTGGTCATGAGCAAGAGCATGAA
CTTCATCGACCCGGCCGGGGCCCAGGTCTGGGACGAGGAGCTGCGCGCCCGCCGGGCCGACGGCGGCGACCTCTATTTCC
ACCGCCCGCGCCCGCCGGTGCTGGAGCTGTGGGAACGCTCGGGCTTCCTCGACGCGCTCGGTCGGGACCATGTGTTTTCC
GACAAGCACAGTGCAATCGCACGGATCGTGCCGCGCCTCGACCCGGCGATCTGCGTCGGCTGCAAGGTCAGGATCTTCGG
CGAGTGCGCCCGCCAGCCCGGCGCGCCGCCGGCGCCGGAGATCTGA

Upstream 100 bases:

>100_bases
GCAGCGAGTTGGGCCACACGGTGGGCCGCGCGATATCGCATCGCGTTCTGCTCCGCGACACGGCCCCTCGGCGGGGCCGG
AACGGCTTCTATCATTCGGC

Downstream 100 bases:

>100_bases
ACCGCCGCGGCCCGATCAGCTGCGCGGTTGCGGTGCCGGCGGCGGCTGCACCGACTGCGCGCGCGCGACGCGCGTGGTGC
CGCCGGTCGAGATCAGCACC

Product: sulfate transporter

Products: Proton [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MSSPAAPAAGPPWLQRCFGPWVRLVSRETLRADLLAGLLGAVLVLPQGIAFASLAGLPPQYGLATAILPCIVAALFGSSL
HVMSGPTNANSLALAAMLTPLAWVRSPDYIELALTVTLLVGVMQTLIGALRLGSIANFISPAALLGFTAGASVLIALHAL
PDLLGMSSGTGLRPMLEALWQRPLEVVHLGSLVVGVVALAVTLAVRHWQRRWPALLLGLAAGTLVAVLLNAGHEDGTFWH
VEQIGEVPLPWPRWHWPDIDISRLRDLVSIAFALTLVALAQSISIAKAVAARSGQRIDANREFLGQGLSNVVGGLTSAYV
SCGSLNRSIPNLEAGARTPLASVFSAGLLLLLVLVSAPLLALIPNAAIAAVLLPVAWNLLDLPGWRRLMRLERSDFAIAA
ATAVATVSLRLEIAILLGSILSLSSYLQRTARPAMRTMGFDSVAPDRPFVVLDGQTEALPECPQLKLLRMEGAVYFGAAQ
HVSDTLHHLRAAPAAPRHLLVMSKSMNFIDPAGAQVWDEELRARRADGGDLYFHRPRPPVLELWERSGFLDALGRDHVFS
DKHSAIARIVPRLDPAICVGCKVRIFGECARQPGAPPAPEI

Sequences:

>Translated_601_residues
MSSPAAPAAGPPWLQRCFGPWVRLVSRETLRADLLAGLLGAVLVLPQGIAFASLAGLPPQYGLATAILPCIVAALFGSSL
HVMSGPTNANSLALAAMLTPLAWVRSPDYIELALTVTLLVGVMQTLIGALRLGSIANFISPAALLGFTAGASVLIALHAL
PDLLGMSSGTGLRPMLEALWQRPLEVVHLGSLVVGVVALAVTLAVRHWQRRWPALLLGLAAGTLVAVLLNAGHEDGTFWH
VEQIGEVPLPWPRWHWPDIDISRLRDLVSIAFALTLVALAQSISIAKAVAARSGQRIDANREFLGQGLSNVVGGLTSAYV
SCGSLNRSIPNLEAGARTPLASVFSAGLLLLLVLVSAPLLALIPNAAIAAVLLPVAWNLLDLPGWRRLMRLERSDFAIAA
ATAVATVSLRLEIAILLGSILSLSSYLQRTARPAMRTMGFDSVAPDRPFVVLDGQTEALPECPQLKLLRMEGAVYFGAAQ
HVSDTLHHLRAAPAAPRHLLVMSKSMNFIDPAGAQVWDEELRARRADGGDLYFHRPRPPVLELWERSGFLDALGRDHVFS
DKHSAIARIVPRLDPAICVGCKVRIFGECARQPGAPPAPEI
>Mature_600_residues
SSPAAPAAGPPWLQRCFGPWVRLVSRETLRADLLAGLLGAVLVLPQGIAFASLAGLPPQYGLATAILPCIVAALFGSSLH
VMSGPTNANSLALAAMLTPLAWVRSPDYIELALTVTLLVGVMQTLIGALRLGSIANFISPAALLGFTAGASVLIALHALP
DLLGMSSGTGLRPMLEALWQRPLEVVHLGSLVVGVVALAVTLAVRHWQRRWPALLLGLAAGTLVAVLLNAGHEDGTFWHV
EQIGEVPLPWPRWHWPDIDISRLRDLVSIAFALTLVALAQSISIAKAVAARSGQRIDANREFLGQGLSNVVGGLTSAYVS
CGSLNRSIPNLEAGARTPLASVFSAGLLLLLVLVSAPLLALIPNAAIAAVLLPVAWNLLDLPGWRRLMRLERSDFAIAAA
TAVATVSLRLEIAILLGSILSLSSYLQRTARPAMRTMGFDSVAPDRPFVVLDGQTEALPECPQLKLLRMEGAVYFGAAQH
VSDTLHHLRAAPAAPRHLLVMSKSMNFIDPAGAQVWDEELRARRADGGDLYFHRPRPPVLELWERSGFLDALGRDHVFSD
KHSAIARIVPRLDPAICVGCKVRIFGECARQPGAPPAPEI

Specific function: Expression in E.coli induces sulfate uptake during early-to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein [H]

COG id: COG0659

COG function: function code P; Sulfate permease and related transporters (MFS superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

Organism=Homo sapiens, GI39752683, Length=491, Percent_Identity=26.8839103869654, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI45827800, Length=495, Percent_Identity=26.6666666666667, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI94721259, Length=473, Percent_Identity=28.3298097251586, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI94721257, Length=473, Percent_Identity=28.3298097251586, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI94721255, Length=473, Percent_Identity=28.3298097251586, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI94721253, Length=473, Percent_Identity=28.3298097251586, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI45827802, Length=438, Percent_Identity=27.8538812785388, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI269784651, Length=487, Percent_Identity=25.6673511293634, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI47131207, Length=638, Percent_Identity=27.8996865203762, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI20336272, Length=638, Percent_Identity=27.8996865203762, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4505697, Length=485, Percent_Identity=23.5051546391753, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4557535, Length=497, Percent_Identity=24.5472837022133, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI20336282, Length=514, Percent_Identity=23.1517509727626, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI16306483, Length=514, Percent_Identity=23.1517509727626, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI100913030, Length=654, Percent_Identity=22.17125382263, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI16418413, Length=385, Percent_Identity=22.0779220779221, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI217272867, Length=385, Percent_Identity=22.0779220779221, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI262206105, Length=168, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI262206075, Length=168, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI262206069, Length=168, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI262206063, Length=168, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI45827804, Length=250, Percent_Identity=28, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI16418457, Length=455, Percent_Identity=23.5164835164835, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI301601599, Length=455, Percent_Identity=23.5164835164835, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI65506789, Length=375, Percent_Identity=26.4, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081859, Length=436, Percent_Identity=29.8165137614679, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI86565215, Length=467, Percent_Identity=25.6959314775161, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17566848, Length=554, Percent_Identity=24.9097472924188, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17551690, Length=518, Percent_Identity=23.1660231660232, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI86564196, Length=621, Percent_Identity=21.5780998389694, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193203292, Length=515, Percent_Identity=22.9126213592233, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562578, Length=441, Percent_Identity=22.4489795918367, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI86565213, Length=249, Percent_Identity=27.3092369477912, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86565209, Length=251, Percent_Identity=23.9043824701195, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86565211, Length=251, Percent_Identity=23.5059760956175, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86564876, Length=377, Percent_Identity=22.5464190981432, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319771, Length=449, Percent_Identity=25.1670378619154, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325260, Length=570, Percent_Identity=20.5263157894737, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323121, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24649801, Length=604, Percent_Identity=23.3443708609272, Blast_Score=142, Evalue=9e-34,
Organism=Drosophila melanogaster, GI21358633, Length=620, Percent_Identity=26.1290322580645, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24651449, Length=494, Percent_Identity=24.8987854251012, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI19922482, Length=437, Percent_Identity=25.858123569794, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24663084, Length=458, Percent_Identity=27.9475982532751, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21357695, Length=458, Percent_Identity=27.9475982532751, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21358229, Length=458, Percent_Identity=24.6724890829694, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666186, Length=525, Percent_Identity=22.2857142857143, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI85815873, Length=512, Percent_Identity=24.21875, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355087, Length=156, Percent_Identity=32.6923076923077, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647160, Length=156, Percent_Identity=32.6923076923077, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002645
- InterPro:   IPR001902
- InterPro:   IPR011547 [H]

Pfam domain/function: PF01740 STAS; PF00916 Sulfate_transp [H]

EC number: NA

Molecular weight: Translated: 63995; Mature: 63864

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPAAPAAGPPWLQRCFGPWVRLVSRETLRADLLAGLLGAVLVLPQGIAFASLAGLPPQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
YGLATAILPCIVAALFGSSLHVMSGPTNANSLALAAMLTPLAWVRSPDYIELALTVTLLV
HHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVMQTLIGALRLGSIANFISPAALLGFTAGASVLIALHALPDLLGMSSGTGLRPMLEALW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
QRPLEVVHLGSLVVGVVALAVTLAVRHWQRRWPALLLGLAAGTLVAVLLNAGHEDGTFWH
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VEQIGEVPLPWPRWHWPDIDISRLRDLVSIAFALTLVALAQSISIAKAVAARSGQRIDAN
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
REFLGQGLSNVVGGLTSAYVSCGSLNRSIPNLEAGARTPLASVFSAGLLLLLVLVSAPLL
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
ALIPNAAIAAVLLPVAWNLLDLPGWRRLMRLERSDFAIAAATAVATVSLRLEIAILLGSI
HHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSLSSYLQRTARPAMRTMGFDSVAPDRPFVVLDGQTEALPECPQLKLLRMEGAVYFGAAQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCEEECHHH
HVSDTLHHLRAAPAAPRHLLVMSKSMNFIDPAGAQVWDEELRARRADGGDLYFHRPRPPV
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCHH
LELWERSGFLDALGRDHVFSDKHSAIARIVPRLDPAICVGCKVRIFGECARQPGAPPAPE
HHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCCCCCCC
I
C
>Mature Secondary Structure 
SSPAAPAAGPPWLQRCFGPWVRLVSRETLRADLLAGLLGAVLVLPQGIAFASLAGLPPQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
YGLATAILPCIVAALFGSSLHVMSGPTNANSLALAAMLTPLAWVRSPDYIELALTVTLLV
HHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVMQTLIGALRLGSIANFISPAALLGFTAGASVLIALHALPDLLGMSSGTGLRPMLEALW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
QRPLEVVHLGSLVVGVVALAVTLAVRHWQRRWPALLLGLAAGTLVAVLLNAGHEDGTFWH
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VEQIGEVPLPWPRWHWPDIDISRLRDLVSIAFALTLVALAQSISIAKAVAARSGQRIDAN
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
REFLGQGLSNVVGGLTSAYVSCGSLNRSIPNLEAGARTPLASVFSAGLLLLLVLVSAPLL
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
ALIPNAAIAAVLLPVAWNLLDLPGWRRLMRLERSDFAIAAATAVATVSLRLEIAILLGSI
HHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSLSSYLQRTARPAMRTMGFDSVAPDRPFVVLDGQTEALPECPQLKLLRMEGAVYFGAAQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCEEECHHH
HVSDTLHHLRAAPAAPRHLLVMSKSMNFIDPAGAQVWDEELRARRADGGDLYFHRPRPPV
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCHH
LELWERSGFLDALGRDHVFSDKHSAIARIVPRLDPAICVGCKVRIFGECARQPGAPPAPE
HHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; SO42- [Periplasm] [C]

Specific reaction: Proton [Periplasm] + SO42- [Periplasm] = Proton [Cytoplasm] + SO42- [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]