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The map label for this gene is fadN [H]

Identifier: 124265610

GI number: 124265610

Start: 450094

End: 452490

Strand: Reverse

Name: fadN [H]

Synonym: Mpe_A0417

Alternate gene names: 124265610

Gene position: 452490-450094 (Counterclockwise)

Preceding gene: 124265611

Following gene: 124265609

Centisome position: 11.19

GC content: 69.04

Gene sequence:

>2397_bases
ATGAGTCGATTCCAAGTCCGCAAGGTCGCCGTGCTCGGCGCCGGCGTGATGGGCGCGCAGATCGCGGCCCACCTCGTCAA
CGTGAAGGTGCCGGTCGTGCTGTTCGACCTGCCGGCCAAGGAAGGGCCGAAGAACGGCATCGTCCTGAAGGCCATCGAGA
ACCTGAAGAAGCTCAAGCCGGCGCCGCTCGGCGTGCCCGAGGACGCCGCGCTGATCGGCGCCGCCAACTACGAGGAGCAC
CTGGCGCTGCTCGGCGAGTGCGACCTGGTGATTGAGGCGATCGCCGAGCGCATGGACTGGAAGCTCGACCTGTACACGAA
GATCGCGCCCCACGTGGCGCCGCGCACGATCCTGGCGTCCAACACGTCGGGCCTGTCGATCACCCGGCTGTCGGCGGCGC
TGCCCGAATCCATCAAGCCGCGCTTCTGCGGGATCCATTTCTTCAACCCGCCGCGCTACATGGCGCTGGTGGAACTGATC
GACACGCCGACCACCGACGATCGCGTGCTCGACGAGCTGGAGAGCTTCGTCACCACCTTCCTCGGCAAGAGCGTGGTACG
CGCGAAGGACACGCCGAACTTCATCGCCAACCGCGTGGGCATCGCCGGCATGCTGGCGACGATCAAGGAGGCCGAGACCT
TCGGCCTCAGCGTCGACGTGGTGGACGACCTCACCGGCAAGAAGCTCGGCCGCGCCAGCAGCGGCACCTTCCGCACCGCC
GACGTGGTGGGCCTGGACACCATGGCGCACGTCATCAAGACGCTGCAGGACAACCTGGCCGATGACCCGTTCTACCCGAG
CTACGCGACGCCGCCGGTGCTGTCGGCACTGATCGCCAAGGGCGCGCTGGGCCAGAAGGTCGGCGCCGGCTTCTACAAGA
AGGTCGGCAAGGACATCCTGCGGCTCGACCCTGCCAAGCAGGATTACGTGCCCGGCGGAGGCAAGGCCGACGAGATCGTC
GCCCGCATGCTGAAGAAGCCGCCGGCCGAGCGCCTGAAGCTGCTGCGCGAGAGCAGCAACCCGCAGGCGCAGTTTCTGTG
GGCGATCCTGCGCGACGCCTTCCACTACGCGGCGGTGCATCTGGAGGACATCGCCGACAACGCGCGCGACGTCGACTTCG
CGATGCGCTGGGGCTTCGGCATGCAGCAGGGCCCGTTCGAGCTGTGGCAGGCCGCCGGCTGGCTGCAGGTGGCGGGCTGG
GTCAGGGACGACATCGACGCCGGCAAGGCGCTGGCGAAGGCGCCGCTGCCGGCCTGGGTGTTCGACGGCCCGGTCGCCGA
GCGCGGCGGCGTGCACACGCCCGAGGGCTCGTGGTCGCCGTCGCGCCAGGCCTTCGTGCCGCGCAGCGAGCTGCCGGCCT
ACCAGCGCCAGCCCTTCCCCGAGAGCGTGCTGGGCAGCGGTGCGGTCGATGCGCTGAAGAGCGGCACCGAGCTGTACCGC
AACGACGAGATCCGCGTCTGGACGCTCGACGGCGAGGTGCTCATTGCATCGATCACTGCCAAGCTGCACCTGATCAGCCC
GACGGTGACCGAAGGGCTGCTGAAGGCGGTCGAGATCGCCGAGGAGACGTTCCAGGGCCTGGTGATCTGGTCGCCCGACG
ACGTGTTCTCGGCCGGCGCCAACCTCGAGGCGCTGATGCCGGTGTTCATGAAGAGCGGCGCCAAGGGCATCGCGCCGGAG
GAAAAGAAGCTGCAGGACGCGATGCTGCGCATCCGCTACGCCGGCGTGCCGGTGGTCGCCGCGGTGCGCGGCCTGGCGCT
GGGCGGCGGCTGCGAGCTGGCCCTCCACAGCGCGCGGCGCGTGGCGGCGATGGAGAGCTACATCGGCCTGGTGGAAGTGG
GCGTGGGCCTGATCCCCGGCGCCGGCGGGCTGACCTACATCGCGCGGCGCGCGGCCGAGATGGCGAACGCCGGCAATGCC
AACGCCGACCTCCTGAAGTTCGTGACCGACGGCTTCACCAGCGCTGCGATGGCCAAGGTGGGCACCAGCGCGATCGAGAG
CCGCAAGCTCGGCTACCTGGTCGACGGCGACGTCATCGTGCCGCACAAGGACGAGCTGCTCTACGTGGCGACCCAGCAAG
CCAAGGCGCTGTTCGCGTCGGGCTACCGCGCGCCGGTGAAGCGGCTGTTCCCGGTGGCCGGCCGCAGCGGCATCGCCACC
ATCAAGGGCCAGCTCGCCAACATGCGCGACGGCGGCTTCATCAGCTCCCACGACTTCCACATCAGCGCGCTGATCGCCGA
CGTGGTGTGCGGCGGCGAGGTCGACGCCGGATCGCTGGTCACCGAGGAGTACCTGATGGCGCTGGAGCGCAGGCACTTCT
GCTCGCTGCTGGAGCACCCCAAGTCCCAGGAACGGATCATGGGCATGCTGCAGACCGGCAAGCCGGTCCGGAACTGA

Upstream 100 bases:

>100_bases
GCGGCTACATCGGCGCACCGCTGCTCGGCCGCACGCAGACCTGGACGCGCGTCGAGTGACGCTGGCGCACGCCCCGAATG
AATCCCTGGAGAACACCGAA

Downstream 100 bases:

>100_bases
TCCTCGACGAGACGCGCATGACCCGCGAGCCGGCACCAACGGACTCCCTCTCCCGCTTGCGGGATAGGGGGCAGGACATC
ACCCCGACTCTCTTCCGCCC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MSRFQVRKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVLKAIENLKKLKPAPLGVPEDAALIGAANYEEH
LALLGECDLVIEAIAERMDWKLDLYTKIAPHVAPRTILASNTSGLSITRLSAALPESIKPRFCGIHFFNPPRYMALVELI
DTPTTDDRVLDELESFVTTFLGKSVVRAKDTPNFIANRVGIAGMLATIKEAETFGLSVDVVDDLTGKKLGRASSGTFRTA
DVVGLDTMAHVIKTLQDNLADDPFYPSYATPPVLSALIAKGALGQKVGAGFYKKVGKDILRLDPAKQDYVPGGGKADEIV
ARMLKKPPAERLKLLRESSNPQAQFLWAILRDAFHYAAVHLEDIADNARDVDFAMRWGFGMQQGPFELWQAAGWLQVAGW
VRDDIDAGKALAKAPLPAWVFDGPVAERGGVHTPEGSWSPSRQAFVPRSELPAYQRQPFPESVLGSGAVDALKSGTELYR
NDEIRVWTLDGEVLIASITAKLHLISPTVTEGLLKAVEIAEETFQGLVIWSPDDVFSAGANLEALMPVFMKSGAKGIAPE
EKKLQDAMLRIRYAGVPVVAAVRGLALGGGCELALHSARRVAAMESYIGLVEVGVGLIPGAGGLTYIARRAAEMANAGNA
NADLLKFVTDGFTSAAMAKVGTSAIESRKLGYLVDGDVIVPHKDELLYVATQQAKALFASGYRAPVKRLFPVAGRSGIAT
IKGQLANMRDGGFISSHDFHISALIADVVCGGEVDAGSLVTEEYLMALERRHFCSLLEHPKSQERIMGMLQTGKPVRN

Sequences:

>Translated_798_residues
MSRFQVRKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVLKAIENLKKLKPAPLGVPEDAALIGAANYEEH
LALLGECDLVIEAIAERMDWKLDLYTKIAPHVAPRTILASNTSGLSITRLSAALPESIKPRFCGIHFFNPPRYMALVELI
DTPTTDDRVLDELESFVTTFLGKSVVRAKDTPNFIANRVGIAGMLATIKEAETFGLSVDVVDDLTGKKLGRASSGTFRTA
DVVGLDTMAHVIKTLQDNLADDPFYPSYATPPVLSALIAKGALGQKVGAGFYKKVGKDILRLDPAKQDYVPGGGKADEIV
ARMLKKPPAERLKLLRESSNPQAQFLWAILRDAFHYAAVHLEDIADNARDVDFAMRWGFGMQQGPFELWQAAGWLQVAGW
VRDDIDAGKALAKAPLPAWVFDGPVAERGGVHTPEGSWSPSRQAFVPRSELPAYQRQPFPESVLGSGAVDALKSGTELYR
NDEIRVWTLDGEVLIASITAKLHLISPTVTEGLLKAVEIAEETFQGLVIWSPDDVFSAGANLEALMPVFMKSGAKGIAPE
EKKLQDAMLRIRYAGVPVVAAVRGLALGGGCELALHSARRVAAMESYIGLVEVGVGLIPGAGGLTYIARRAAEMANAGNA
NADLLKFVTDGFTSAAMAKVGTSAIESRKLGYLVDGDVIVPHKDELLYVATQQAKALFASGYRAPVKRLFPVAGRSGIAT
IKGQLANMRDGGFISSHDFHISALIADVVCGGEVDAGSLVTEEYLMALERRHFCSLLEHPKSQERIMGMLQTGKPVRN
>Mature_797_residues
SRFQVRKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVLKAIENLKKLKPAPLGVPEDAALIGAANYEEHL
ALLGECDLVIEAIAERMDWKLDLYTKIAPHVAPRTILASNTSGLSITRLSAALPESIKPRFCGIHFFNPPRYMALVELID
TPTTDDRVLDELESFVTTFLGKSVVRAKDTPNFIANRVGIAGMLATIKEAETFGLSVDVVDDLTGKKLGRASSGTFRTAD
VVGLDTMAHVIKTLQDNLADDPFYPSYATPPVLSALIAKGALGQKVGAGFYKKVGKDILRLDPAKQDYVPGGGKADEIVA
RMLKKPPAERLKLLRESSNPQAQFLWAILRDAFHYAAVHLEDIADNARDVDFAMRWGFGMQQGPFELWQAAGWLQVAGWV
RDDIDAGKALAKAPLPAWVFDGPVAERGGVHTPEGSWSPSRQAFVPRSELPAYQRQPFPESVLGSGAVDALKSGTELYRN
DEIRVWTLDGEVLIASITAKLHLISPTVTEGLLKAVEIAEETFQGLVIWSPDDVFSAGANLEALMPVFMKSGAKGIAPEE
KKLQDAMLRIRYAGVPVVAAVRGLALGGGCELALHSARRVAAMESYIGLVEVGVGLIPGAGGLTYIARRAAEMANAGNAN
ADLLKFVTDGFTSAAMAKVGTSAIESRKLGYLVDGDVIVPHKDELLYVATQQAKALFASGYRAPVKRLFPVAGRSGIATI
KGQLANMRDGGFISSHDFHISALIADVVCGGEVDAGSLVTEEYLMALERRHFCSLLEHPKSQERIMGMLQTGKPVRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=298, Percent_Identity=36.241610738255, Blast_Score=136, Evalue=9e-32,
Organism=Homo sapiens, GI296179427, Length=313, Percent_Identity=35.1437699680511, Blast_Score=130, Evalue=7e-30,
Organism=Homo sapiens, GI20127408, Length=298, Percent_Identity=30.8724832214765, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI261878539, Length=400, Percent_Identity=24.75, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI68989263, Length=400, Percent_Identity=24.75, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1787661, Length=301, Percent_Identity=30.5647840531561, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790281, Length=311, Percent_Identity=27.6527331189711, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788682, Length=223, Percent_Identity=29.5964125560538, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17549919, Length=295, Percent_Identity=31.5254237288136, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17563036, Length=303, Percent_Identity=31.6831683168317, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17553560, Length=293, Percent_Identity=30.0341296928328, Blast_Score=112, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17558304, Length=394, Percent_Identity=27.9187817258883, Blast_Score=90, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17508953, Length=293, Percent_Identity=32.0819112627986, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25144276, Length=295, Percent_Identity=32.5423728813559, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17508951, Length=295, Percent_Identity=32.5423728813559, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985923, Length=253, Percent_Identity=28.0632411067194, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583077, Length=430, Percent_Identity=27.2093023255814, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583079, Length=430, Percent_Identity=27.2093023255814, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921000, Length=430, Percent_Identity=27.2093023255814, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45549573, Length=227, Percent_Identity=28.6343612334802, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 85762; Mature: 85631

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFQVRKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVLKAIENLKKLKP
CCCHHEEEEHHHCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCEEHHHHHHHHHCCC
APLGVPEDAALIGAANYEEHLALLGECDLVIEAIAERMDWKLDLYTKIAPHVAPRTILAS
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHCCCCCCCEEEEC
NTSGLSITRLSAALPESIKPRFCGIHFFNPPRYMALVELIDTPTTDDRVLDELESFVTTF
CCCCCEEEHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LGKSVVRAKDTPNFIANRVGIAGMLATIKEAETFGLSVDVVDDLTGKKLGRASSGTFRTA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCHHCCCCCCCCEEEE
DVVGLDTMAHVIKTLQDNLADDPFYPSYATPPVLSALIAKGALGQKVGAGFYKKVGKDIL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
RLDPAKQDYVPGGGKADEIVARMLKKPPAERLKLLRESSNPQAQFLWAILRDAFHYAAVH
HCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LEDIADNARDVDFAMRWGFGMQQGPFELWQAAGWLQVAGWVRDDIDAGKALAKAPLPAWV
HHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
FDGPVAERGGVHTPEGSWSPSRQAFVPRSELPAYQRQPFPESVLGSGAVDALKSGTELYR
ECCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCHHHHCCCHHHHHHCCHHHHC
NDEIRVWTLDGEVLIASITAKLHLISPTVTEGLLKAVEIAEETFQGLVIWSPDDVFSAGA
CCCEEEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHCCC
NLEALMPVFMKSGAKGIAPEEKKLQDAMLRIRYAGVPVVAAVRGLALGGGCELALHSARR
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
VAAMESYIGLVEVGVGLIPGAGGLTYIARRAAEMANAGNANADLLKFVTDGFTSAAMAKV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHH
GTSAIESRKLGYLVDGDVIVPHKDELLYVATQQAKALFASGYRAPVKRLFPVAGRSGIAT
HHHHHHHCCCCEEECCCEECCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCEE
IKGQLANMRDGGFISSHDFHISALIADVVCGGEVDAGSLVTEEYLMALERRHFCSLLEHP
HHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KSQERIMGMLQTGKPVRN
CHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SRFQVRKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVLKAIENLKKLKP
CCHHEEEEHHHCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCEEHHHHHHHHHCCC
APLGVPEDAALIGAANYEEHLALLGECDLVIEAIAERMDWKLDLYTKIAPHVAPRTILAS
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHCCCCCCCEEEEC
NTSGLSITRLSAALPESIKPRFCGIHFFNPPRYMALVELIDTPTTDDRVLDELESFVTTF
CCCCCEEEHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LGKSVVRAKDTPNFIANRVGIAGMLATIKEAETFGLSVDVVDDLTGKKLGRASSGTFRTA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCHHCCCCCCCCEEEE
DVVGLDTMAHVIKTLQDNLADDPFYPSYATPPVLSALIAKGALGQKVGAGFYKKVGKDIL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
RLDPAKQDYVPGGGKADEIVARMLKKPPAERLKLLRESSNPQAQFLWAILRDAFHYAAVH
HCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LEDIADNARDVDFAMRWGFGMQQGPFELWQAAGWLQVAGWVRDDIDAGKALAKAPLPAWV
HHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
FDGPVAERGGVHTPEGSWSPSRQAFVPRSELPAYQRQPFPESVLGSGAVDALKSGTELYR
ECCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCHHHHCCCHHHHHHCCHHHHC
NDEIRVWTLDGEVLIASITAKLHLISPTVTEGLLKAVEIAEETFQGLVIWSPDDVFSAGA
CCCEEEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHCCC
NLEALMPVFMKSGAKGIAPEEKKLQDAMLRIRYAGVPVVAAVRGLALGGGCELALHSARR
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
VAAMESYIGLVEVGVGLIPGAGGLTYIARRAAEMANAGNANADLLKFVTDGFTSAAMAKV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHH
GTSAIESRKLGYLVDGDVIVPHKDELLYVATQQAKALFASGYRAPVKRLFPVAGRSGIAT
HHHHHHHCCCCEEECCCEECCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCEE
IKGQLANMRDGGFISSHDFHISALIADVVCGGEVDAGSLVTEEYLMALERRHFCSLLEHP
HHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KSQERIMGMLQTGKPVRN
CHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]