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The map label for this gene is hisC1 [H]

Identifier: 124024434

GI number: 124024434

Start: 2416517

End: 2417650

Strand: Reverse

Name: hisC1 [H]

Synonym: P9303_27461

Alternate gene names: 124024434

Gene position: 2417650-2416517 (Counterclockwise)

Preceding gene: 124024435

Following gene: 124024431

Centisome position: 90.12

GC content: 55.03

Gene sequence:

>1134_bases
ATGGGGTCTTCACCTGCACGAATGAGTTCTGGTGCCCCCGCTCCTCGGGTGGAAGTGGAGTGTCTGAAGGCCTATAGCGC
TCCGCTTGAGGGTCGCCGTGGATTGCTGCGCCTTGATTTTAATGAGAATACGATCGGCCCTAGCCCTCGTGTACTCGAGG
CGTTGCGAGCGATCCCTGCTGATCAGATCGCTGTTTATCCGGAGTACGACGGGTTGCGAGAAGCGGTGGTGGCCAATTTG
AGCAATCGTGATCAAGGCCGACCAGGGCTGACCCAGCCACTTAGCCCTAGTCAGATTGGCTTATTCAACGGCGTTGATGC
AGCGATTCACGCCATCTTTCATGCCTATGGCGATCGAGGCGATCAGCTGCTCACCACCAGCCCTACTTTTGGTTATTACA
CGCCTTGCGCCCAGATGCAGGGGATGGAGATTTTGGCCATTCCCTATGAAGGCAGCGACTTTTGCTTTCCGCTTGAGGCG
ATTCGTAAGCGTGTGCTGGAGCAGAAGCCAAGGCTGTTGGTGCTCTGCAATCCCAACAATCCCACTGGCACTCGCTTGGC
ACCAGAACAGATTCAGCAACTTGCCATTGCTGCGCCTGAAACGTTGGTGGTAGTCGATGAGCTTTATGAGGCGTTCACGG
GCGATAGCGTTTTGCCGCAAGCAGATTTCAGTGTTACCCCGAATCTGTTGGTGTTGCGTTCGCTGGCCAAAACCGCAGGT
TTGGCGGGTCTTCGCATGGGGTTTGCGATCGGCTCTGCTGATGTCATCGATCGCGTCAGTCGTGTGACTGGGCCTTATGA
CATCAATAGCTTTGCGGTAACAGCAGCTTTCGCGGCTCTTGATGATCAGGCTTACGTGGATGCCTACGTGGCTGATGTGT
TGAAGGCGCGTGACTGGATTAGCGCTCGTCTTGAAGCCTCTGGTTTGCCTTACCACCTCGATGGAGGGAATTACCTGTTG
ATCTGGCCGCAGCAGCAACCAGCAGAGGTGGAAGCAGCCTTACGCAAGCGGGGCATCTTGGTTCGGCTGATGACTGGTAA
ACCGCTGATTGATGGATCCTTGCGGGTCAGCATCGGCACGATTGAGCAAATGCAGCAATTTTGGGAGAACTTTGCGGCGA
TCGAGTCTGTTTAG

Upstream 100 bases:

>100_bases
AACCATCTCGTAGCTGTCGCCTAGCGCTCTGCCGGCTCACGGCAGATACCCTAAAACTAGGGCTGTCGTTGTTGGGTATT
CCCACGCTGGAGCGGATGTG

Downstream 100 bases:

>100_bases
TCCCGCCCATGATCAGCAGCAGCAAAAGCCTGATGCAGAATTTGAATTGCTTTTGGAGTCATAATTACGGGCTGCAATGT
CCCTGGCTGACACCCTTATT

Product: aminotransferases class-I

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MGSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPADQIAVYPEYDGLREAVVANL
SNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRGDQLLTTSPTFGYYTPCAQMQGMEILAIPYEGSDFCFPLEA
IRKRVLEQKPRLLVLCNPNNPTGTRLAPEQIQQLAIAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWISARLEASGLPYHLDGGNYLL
IWPQQQPAEVEAALRKRGILVRLMTGKPLIDGSLRVSIGTIEQMQQFWENFAAIESV

Sequences:

>Translated_377_residues
MGSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPADQIAVYPEYDGLREAVVANL
SNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRGDQLLTTSPTFGYYTPCAQMQGMEILAIPYEGSDFCFPLEA
IRKRVLEQKPRLLVLCNPNNPTGTRLAPEQIQQLAIAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWISARLEASGLPYHLDGGNYLL
IWPQQQPAEVEAALRKRGILVRLMTGKPLIDGSLRVSIGTIEQMQQFWENFAAIESV
>Mature_376_residues
GSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPADQIAVYPEYDGLREAVVANLS
NRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRGDQLLTTSPTFGYYTPCAQMQGMEILAIPYEGSDFCFPLEAI
RKRVLEQKPRLLVLCNPNNPTGTRLAPEQIQQLAIAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAGL
AGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWISARLEASGLPYHLDGGNYLLI
WPQQQPAEVEAALRKRGILVRLMTGKPLIDGSLRVSIGTIEQMQQFWENFAAIESV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=282, Percent_Identity=28.3687943262411, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788722, Length=206, Percent_Identity=28.6407766990291, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788627, Length=213, Percent_Identity=25.8215962441315, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=353, Percent_Identity=27.4787535410765, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40916; Mature: 40785

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPA
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
DQIAVYPEYDGLREAVVANLSNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRG
CCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
DQLLTTSPTFGYYTPCAQMQGMEILAIPYEGSDFCFPLEAIRKRVLEQKPRLLVLCNPNN
CEEEEECCCCCCCCCHHHHCCCEEEEEECCCCCCEECHHHHHHHHHHCCCCEEEEECCCC
PTGTRLAPEQIQQLAIAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
CCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWI
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SARLEASGLPYHLDGGNYLLIWPQQQPAEVEAALRKRGILVRLMTGKPLIDGSLRVSIGT
HHHHHCCCCCEEECCCCEEEEECCCCCHHHHHHHHHCCEEEEEECCCCEECCCEEEEEHH
IEQMQQFWENFAAIESV
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSSPARMSSGAPAPRVEVECLKAYSAPLEGRRGLLRLDFNENTIGPSPRVLEALRAIPA
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
DQIAVYPEYDGLREAVVANLSNRDQGRPGLTQPLSPSQIGLFNGVDAAIHAIFHAYGDRG
CCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
DQLLTTSPTFGYYTPCAQMQGMEILAIPYEGSDFCFPLEAIRKRVLEQKPRLLVLCNPNN
CEEEEECCCCCCCCCHHHHCCCEEEEEECCCCCCEECHHHHHHHHHHCCCCEEEEECCCC
PTGTRLAPEQIQQLAIAAPETLVVVDELYEAFTGDSVLPQADFSVTPNLLVLRSLAKTAG
CCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
LAGLRMGFAIGSADVIDRVSRVTGPYDINSFAVTAAFAALDDQAYVDAYVADVLKARDWI
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SARLEASGLPYHLDGGNYLLIWPQQQPAEVEAALRKRGILVRLMTGKPLIDGSLRVSIGT
HHHHHCCCCCEEECCCCEEEEECCCCCHHHHHHHHHCCEEEEEECCCCEECCCEEEEEHH
IEQMQQFWENFAAIESV
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA