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The map label for this gene is purE [H]

Identifier: 124024401

GI number: 124024401

Start: 2391748

End: 2392323

Strand: Reverse

Name: purE [H]

Synonym: P9303_27131

Alternate gene names: 124024401

Gene position: 2392323-2391748 (Counterclockwise)

Preceding gene: 124024404

Following gene: 124024400

Centisome position: 89.18

GC content: 57.99

Gene sequence:

>576_bases
TTGTCGTCATTATTCATCGTGACCTCTGCTTCTCTGCCTGTGCCTTTGGCAGCTGCTGAATCGCCGCCGCAGGTGGCTGT
GGTGATGGGTAGTGATTCCGATTTACCAACCCTGCAACCGGCTGTCACCGTCTTAGAGGAGTTCGGTGTGAAGGTGGAGG
TGCGTGTGCTTTCCGCGCACCGTACGCCCCTTGAGATGGTGGCCTTTGCAAAGGAGGCTCATCAGAGAGGTTTGAAGGTG
ATCGTGGCAGGTGCCGGCGGTGCTGCTCATTTGCCGGGCATGGTGGCGTCACTGACCACGCTGCCAGTGATTGGAGTACC
TGTGCAGAGCAGGGCTCTTTCCGGGGTGGATTCCCTGCATTCGATTGTGCAGATGCCTGGGGGAATCCCTGTGGCAACAG
TGGCGATTGGTGGAGGGCTTAATGCTGGCTTGCTGGCGGCTCAGATCCTGGCGATCTGTGATCCACAGCTTGCAGAGCGG
TTGAGGGCCTACCGCCAGGATCTTCACGATGCTGTGGTAGCCAAGGATGCTCGCTTGTTGGAGCTTGGCAGTGAGGCTTA
TTTGGGGCAGATGTGA

Upstream 100 bases:

>100_bases
CACAGCTTGGTGTCTATGGCATTTAGAGGTTGGGGCAGGCGGATGTGGGTGATCCGATGCATGGGAGGTGGCCAGGTGGT
GCTAGTGCGGGACCATGGCA

Downstream 100 bases:

>100_bases
CGGTCCTGTTGGAACTGATCAACTCCGATGAAGCCATGGGTATGGTCCCGGCTTGATCATTGCGTATTGAGGTTTGATGC
TCAGTCATCCAGTGGCCCGC

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MSSLFIVTSASLPVPLAAAESPPQVAVVMGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKV
IVAGAGGAAHLPGMVASLTTLPVIGVPVQSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAER
LRAYRQDLHDAVVAKDARLLELGSEAYLGQM

Sequences:

>Translated_191_residues
MSSLFIVTSASLPVPLAAAESPPQVAVVMGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKV
IVAGAGGAAHLPGMVASLTTLPVIGVPVQSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAER
LRAYRQDLHDAVVAKDARLLELGSEAYLGQM
>Mature_190_residues
SSLFIVTSASLPVPLAAAESPPQVAVVMGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAHRTPLEMVAFAKEAHQRGLKVI
VAGAGGAAHLPGMVASLTTLPVIGVPVQSRALSGVDSLHSIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAERL
RAYRQDLHDAVVAKDARLLELGSEAYLGQM

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=160, Percent_Identity=50, Blast_Score=140, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324702, Length=191, Percent_Identity=49.2146596858639, Blast_Score=182, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 19622; Mature: 19491

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLFIVTSASLPVPLAAAESPPQVAVVMGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAH
CCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEEECC
RTPLEMVAFAKEAHQRGLKVIVAGAGGAAHLPGMVASLTTLPVIGVPVQSRALSGVDSLH
CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHH
SIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAERLRAYRQDLHDAVVAKDARLL
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHH
ELGSEAYLGQM
HCCCHHHCCCC
>Mature Secondary Structure 
SSLFIVTSASLPVPLAAAESPPQVAVVMGSDSDLPTLQPAVTVLEEFGVKVEVRVLSAH
CCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEEECC
RTPLEMVAFAKEAHQRGLKVIVAGAGGAAHLPGMVASLTTLPVIGVPVQSRALSGVDSLH
CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHH
SIVQMPGGIPVATVAIGGGLNAGLLAAQILAICDPQLAERLRAYRQDLHDAVVAKDARLL
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHH
ELGSEAYLGQM
HCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]