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The map label for this gene is cysK [H]

Identifier: 124024319

GI number: 124024319

Start: 2321992

End: 2322978

Strand: Reverse

Name: cysK [H]

Synonym: P9303_26311

Alternate gene names: 124024319

Gene position: 2322978-2321992 (Counterclockwise)

Preceding gene: 124024320

Following gene: 124024318

Centisome position: 86.59

GC content: 57.75

Gene sequence:

>987_bases
ATGACAATGACATCGCCCATGCCTATCGCTGCTGACATTACGGCCTTAGTTGGGTGCACTCCGTTGGTGCGCCTTAATCG
CTTGCCACAGGTCAGTGGTTGCCATGCGGAGGTGCTGGCCAAGTTGGAAAGCTTCAACCCCACTGCCTCGGTTAAAGACC
GCATCGCGGGGGCCATGATCCATGCAGCGGAGGAAGCTGGAACCATTGCTCCGGGGCGCACCGTGCTGGTGGAACCCACC
AGTGGCAACACTGGGATCGCCTTGGCCATGGTGGCTGCCGCCCGAGGCTATCGCCTCATTCTCACCATGCCGGACACGAT
GAGTACAGAGCGTCGCGCCATGCTTAGGGCCTATGGCGCTGAACTGCAACTCACCCCAGGCAGCGATGGAATGACTGGTT
CCATTGAGTTGGCAAAGGAGTTGGTGGCAACCATCCCTGAGGCTTATCTGCTGCAGCAGTTTGATAATCCTGCGAATCCG
CAGGTGCATGAGCGCACAACCGCAGAGGAGATCTGGAATGATTGCGAGGGGCGGTTGGATGGTCTGATTACTGGAGTAGG
AACGGGGGGCACACTCACAGGTTGTGCGCGTTTGCTCAAGCAACGCAATCCAAGCCTGCGAGTGTTTGCGGTAGAGCCAG
CGTTAAGCCCTGTTTTGGCAGGTGGGAGCCCTGCTCCCCATCGCATTCAGGGGATTGGTGCTGGCTTCATTCCTAGCGTT
CTTGATCTCTCTTTGATCGATGAGATCCTGCCGGTCTCTGATGACGACGCGATGGAGATGGGTCGGCGCTTGGCCAGGGA
GGAGGGCTTGCTAAGTGGGGTAAGCAGTGGCGCTGCTGTTGCGGCTGCATTGCAAGTGGGTAGTAGGGCTGAGATGGTGG
GCAAGCGTCTTGTTGTTGTCTTGGCAAGTTTTGGTGAGCGTTATCTATCAACGCCGATGTTTAGCGCTGCTTCGGCGGTG
CCGGCGCAGCGTGATGGATACCTTTGA

Upstream 100 bases:

>100_bases
GAAGCTACTCCTCACAATCTCTATCAATTGCCGCCCTCCGCAAACGGGGGGCTTTTTTATGTTCTGATCATCATCGCTTT
GTTTGGATGGGTAAGAGGCC

Downstream 100 bases:

>100_bases
TGTCTTCCAAATGACTGGTTTCTATGGCTGCAGATCCCTATCAGGTGTTGGGAGTAACCTCCACAGCTAGCTCGGCTGAG
ATCAAGGCTGCCTATCGCCA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTMTSPMPIAADITALVGCTPLVRLNRLPQVSGCHAEVLAKLESFNPTASVKDRIAGAMIHAAEEAGTIAPGRTVLVEPT
SGNTGIALAMVAAARGYRLILTMPDTMSTERRAMLRAYGAELQLTPGSDGMTGSIELAKELVATIPEAYLLQQFDNPANP
QVHERTTAEEIWNDCEGRLDGLITGVGTGGTLTGCARLLKQRNPSLRVFAVEPALSPVLAGGSPAPHRIQGIGAGFIPSV
LDLSLIDEILPVSDDDAMEMGRRLAREEGLLSGVSSGAAVAAALQVGSRAEMVGKRLVVVLASFGERYLSTPMFSAASAV
PAQRDGYL

Sequences:

>Translated_328_residues
MTMTSPMPIAADITALVGCTPLVRLNRLPQVSGCHAEVLAKLESFNPTASVKDRIAGAMIHAAEEAGTIAPGRTVLVEPT
SGNTGIALAMVAAARGYRLILTMPDTMSTERRAMLRAYGAELQLTPGSDGMTGSIELAKELVATIPEAYLLQQFDNPANP
QVHERTTAEEIWNDCEGRLDGLITGVGTGGTLTGCARLLKQRNPSLRVFAVEPALSPVLAGGSPAPHRIQGIGAGFIPSV
LDLSLIDEILPVSDDDAMEMGRRLAREEGLLSGVSSGAAVAAALQVGSRAEMVGKRLVVVLASFGERYLSTPMFSAASAV
PAQRDGYL
>Mature_327_residues
TMTSPMPIAADITALVGCTPLVRLNRLPQVSGCHAEVLAKLESFNPTASVKDRIAGAMIHAAEEAGTIAPGRTVLVEPTS
GNTGIALAMVAAARGYRLILTMPDTMSTERRAMLRAYGAELQLTPGSDGMTGSIELAKELVATIPEAYLLQQFDNPANPQ
VHERTTAEEIWNDCEGRLDGLITGVGTGGTLTGCARLLKQRNPSLRVFAVEPALSPVLAGGSPAPHRIQGIGAGFIPSVL
DLSLIDEILPVSDDDAMEMGRRLAREEGLLSGVSSGAAVAAALQVGSRAEMVGKRLVVVLASFGERYLSTPMFSAASAVP
AQRDGYL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=42.5806451612903, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=42.5806451612903, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=42.5806451612903, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=54.746835443038, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=44.4816053511706, Blast_Score=227, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=52.6666666666667, Blast_Score=321, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=52.5083612040134, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=53.0944625407166, Blast_Score=311, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=53.2423208191126, Blast_Score=307, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=50.5016722408027, Blast_Score=276, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=51.6431924882629, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17534315, Length=306, Percent_Identity=40.8496732026144, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=310, Percent_Identity=39.0322580645161, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=47.8991596638655, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=287, Percent_Identity=39.3728222996516, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24643623, Length=313, Percent_Identity=40.2555910543131, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129101, Length=313, Percent_Identity=40.2555910543131, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34316; Mature: 34185

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTSPMPIAADITALVGCTPLVRLNRLPQVSGCHAEVLAKLESFNPTASVKDRIAGAMI
CCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
HAAEEAGTIAPGRTVLVEPTSGNTGIALAMVAAARGYRLILTMPDTMSTERRAMLRAYGA
HHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCC
ELQLTPGSDGMTGSIELAKELVATIPEAYLLQQFDNPANPQVHERTTAEEIWNDCEGRLD
EEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLITGVGTGGTLTGCARLLKQRNPSLRVFAVEPALSPVLAGGSPAPHRIQGIGAGFIPSV
HEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCHHHCCCCCHHHHH
LDLSLIDEILPVSDDDAMEMGRRLAREEGLLSGVSSGAAVAAALQVGSRAEMVGKRLVVV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHH
LASFGERYLSTPMFSAASAVPAQRDGYL
HHHHHHHHHCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TMTSPMPIAADITALVGCTPLVRLNRLPQVSGCHAEVLAKLESFNPTASVKDRIAGAMI
CCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
HAAEEAGTIAPGRTVLVEPTSGNTGIALAMVAAARGYRLILTMPDTMSTERRAMLRAYGA
HHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCC
ELQLTPGSDGMTGSIELAKELVATIPEAYLLQQFDNPANPQVHERTTAEEIWNDCEGRLD
EEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLITGVGTGGTLTGCARLLKQRNPSLRVFAVEPALSPVLAGGSPAPHRIQGIGAGFIPSV
HEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCHHHCCCCCHHHHH
LDLSLIDEILPVSDDDAMEMGRRLAREEGLLSGVSSGAAVAAALQVGSRAEMVGKRLVVV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHH
LASFGERYLSTPMFSAASAVPAQRDGYL
HHHHHHHHHCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]