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The map label for this gene is folK [H]

Identifier: 124024208

GI number: 124024208

Start: 2216074

End: 2216820

Strand: Reverse

Name: folK [H]

Synonym: P9303_25191

Alternate gene names: 124024208

Gene position: 2216820-2216074 (Counterclockwise)

Preceding gene: 124024210

Following gene: 124024207

Centisome position: 82.63

GC content: 58.1

Gene sequence:

>747_bases
TTGAGAGTTCCATGGCCTGTGATTGCGGCAAGAGGAAAAGCACGAGTGGCCATGTCCTGGCCTGCTCGATCTCTGGACCT
TGTGTTGGCAGTTGCGGCCGATCCGCTTGCAACCATGGAGTCCCCCCGGCTCGATGACGTGTGCGCCAGTCTCGCTGATC
AACTCGGAGTTTCTACTGCTTATTCTGCTCCAAGCACGTTGGCTGTGGCATTAGGAGCCAATTTGGCTAGTGCTTTTGGA
CCTCCTCGTGCCACCTTGAGGGCAGTGCGGCCTGAGTTAGAGCAGACCATCGATGAGTGGCTCTCAACATCGCTTGGAGA
GGCATCAGGCGCAAGGGTGAATCCTGCAGGTTTGCGTTGCCGTTGGTCGCCATTATTTGAGACCGACCCCGTTGGCGGTC
CACCCGAACAGCCTGTCTACATCAATGCGGTAGTTGTGGTGGATGGGCCGCGGCTTGCTTTGTTGCAGCCTTGTGAAGCC
GCTGCGCTGTCCTTGTTAGCCAGGCTTCTGGCCCTGGAGAAGCGCTTCGGACGAGATCGCCAGGCAGAGTTGATGCGCTG
GGAATCGCGCTCACTGGATCTTGATTTGCTTGCCTGGGGCGCACTACAGGTTCAGCACGAGGCCTTAATCCTTCCTCACC
CCCGTCTGATTGAACGAAGTTTTGTCGTGGTGCCACTTGCAGCGGCCCTAACGGGAGTGGGTCAGGGGCCGCGCCGGATT
CCCCCTGATTTGGACTGGCTTGAATAG

Upstream 100 bases:

>100_bases
ATGCAGTCCCCGTGCCAAGACCGATTTGCCAGTGCCGCGGCCGCCGGCGATCACCACCCCACCCAGTTCTGGATCAACCG
CTGCTAGGAGCAGTGAAAGC

Downstream 100 bases:

>100_bases
GGGTGGCGCAATTCAAGTCCTTGTCTGGTCATCAGCCACCATGCTGGGAGTTCTTTGTTTGTGGTCAACATGGTGCCTCT
TCCGCCCCCTGAGCCGTCTT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRVPWPVIAARGKARVAMSWPARSLDLVLAVAADPLATMESPRLDDVCASLADQLGVSTAYSAPSTLAVALGANLASAFG
PPRATLRAVRPELEQTIDEWLSTSLGEASGARVNPAGLRCRWSPLFETDPVGGPPEQPVYINAVVVVDGPRLALLQPCEA
AALSLLARLLALEKRFGRDRQAELMRWESRSLDLDLLAWGALQVQHEALILPHPRLIERSFVVVPLAAALTGVGQGPRRI
PPDLDWLE

Sequences:

>Translated_248_residues
MRVPWPVIAARGKARVAMSWPARSLDLVLAVAADPLATMESPRLDDVCASLADQLGVSTAYSAPSTLAVALGANLASAFG
PPRATLRAVRPELEQTIDEWLSTSLGEASGARVNPAGLRCRWSPLFETDPVGGPPEQPVYINAVVVVDGPRLALLQPCEA
AALSLLARLLALEKRFGRDRQAELMRWESRSLDLDLLAWGALQVQHEALILPHPRLIERSFVVVPLAAALTGVGQGPRRI
PPDLDWLE
>Mature_248_residues
MRVPWPVIAARGKARVAMSWPARSLDLVLAVAADPLATMESPRLDDVCASLADQLGVSTAYSAPSTLAVALGANLASAFG
PPRATLRAVRPELEQTIDEWLSTSLGEASGARVNPAGLRCRWSPLFETDPVGGPPEQPVYINAVVVVDGPRLALLQPCEA
AALSLLARLLALEKRFGRDRQAELMRWESRSLDLDLLAWGALQVQHEALILPHPRLIERSFVVVPLAAALTGVGQGPRRI
PPDLDWLE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 26691; Mature: 26691

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVPWPVIAARGKARVAMSWPARSLDLVLAVAADPLATMESPRLDDVCASLADQLGVSTA
CCCCCCCEECCCCEEEEEECCCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHCCCCC
YSAPSTLAVALGANLASAFGPPRATLRAVRPELEQTIDEWLSTSLGEASGARVNPAGLRC
CCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEE
RWSPLFETDPVGGPPEQPVYINAVVVVDGPRLALLQPCEAAALSLLARLLALEKRFGRDR
EECCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCH
QAELMRWESRSLDLDLLAWGALQVQHEALILPHPRLIERSFVVVPLAAALTGVGQGPRRI
HHHHHHHHCCCCCCHHEEHHHEEEECCEEECCCCHHHHCCCCEEEHHHHHHHCCCCCCCC
PPDLDWLE
CCCCCCCC
>Mature Secondary Structure
MRVPWPVIAARGKARVAMSWPARSLDLVLAVAADPLATMESPRLDDVCASLADQLGVSTA
CCCCCCCEECCCCEEEEEECCCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHCCCCC
YSAPSTLAVALGANLASAFGPPRATLRAVRPELEQTIDEWLSTSLGEASGARVNPAGLRC
CCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEE
RWSPLFETDPVGGPPEQPVYINAVVVVDGPRLALLQPCEAAALSLLARLLALEKRFGRDR
EECCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCH
QAELMRWESRSLDLDLLAWGALQVQHEALILPHPRLIERSFVVVPLAAALTGVGQGPRRI
HHHHHHHHCCCCCCHHEEHHHEEEECCEEECCCCHHHHCCCCEEEHHHHHHHCCCCCCCC
PPDLDWLE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]