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The map label for this gene is nudF [H]

Identifier: 124024207

GI number: 124024207

Start: 2215444

End: 2216013

Strand: Reverse

Name: nudF [H]

Synonym: P9303_25181

Alternate gene names: 124024207

Gene position: 2216013-2215444 (Counterclockwise)

Preceding gene: 124024208

Following gene: 124024203

Centisome position: 82.6

GC content: 55.61

Gene sequence:

>570_bases
GTGGTCAACATGGTGCCTCTTCCGCCCCCTGAGCCGTCTTTGCTGTTGGAAACCACAGCAGCATTGGAGGCAAGAAAGAT
TCGTTTTGAGATCAACCGTTTTGAGCTGCCGATTGGGGTACAGGGTCTCTTTGGTCTGATTCGCCATCCTGGTGCTTCCT
TAGCGGTGCCAATCACTGCCGATGGCAGGGTTGTGGTGCTGCGTCAGTACCGCTTTGCGGTAGCCCGCCGCATCCTGGAA
TTTCCTGCTGGCACGCTTGAGGATGGTGAAGATCCCCAGGCTTCGATGGAGCGGGAACTGGCAGAGGAGGCTGGCTACAG
CGCAGCTCGCTGGGATTCTTTGGGGCAGATGCTGCCTTGCCCTGGCTACTCCGATGAAGTCATACACCTTTTTCTGGCCC
GCGACCTTAAAGCCCTGAGCGAATCTCCTGCTGGTGATGAAGACGAGGATCTTGAGGTGCTGCATATGACCCCAGCTGAA
TTCGATGCTTGCTTAGCTAGTGGTGATGAAGCTCTGGATGGTAAGAGCATTACCGCTTGGTATCGGGCGCGTCAGTTGTT
GGGTCTCTAA

Upstream 100 bases:

>100_bases
GCCGCGCCGGATTCCCCCTGATTTGGACTGGCTTGAATAGGGGTGGCGCAATTCAAGTCCTTGTCTGGTCATCAGCCACC
ATGCTGGGAGTTCTTTGTTT

Downstream 100 bases:

>100_bases
CGATCACCATCCTGTTGGTTGCTCTGGTATTACTGCGAAGCAGTATTTGTGTTTGGAGGTTTTGCCTGATAACAAGTCAT
AGCAGGTATTAAATAAGGCT

Product: NUDIX hydrolase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MVNMVPLPPPEPSLLLETTAALEARKIRFEINRFELPIGVQGLFGLIRHPGASLAVPITADGRVVVLRQYRFAVARRILE
FPAGTLEDGEDPQASMERELAEEAGYSAARWDSLGQMLPCPGYSDEVIHLFLARDLKALSESPAGDEDEDLEVLHMTPAE
FDACLASGDEALDGKSITAWYRARQLLGL

Sequences:

>Translated_189_residues
MVNMVPLPPPEPSLLLETTAALEARKIRFEINRFELPIGVQGLFGLIRHPGASLAVPITADGRVVVLRQYRFAVARRILE
FPAGTLEDGEDPQASMERELAEEAGYSAARWDSLGQMLPCPGYSDEVIHLFLARDLKALSESPAGDEDEDLEVLHMTPAE
FDACLASGDEALDGKSITAWYRARQLLGL
>Mature_189_residues
MVNMVPLPPPEPSLLLETTAALEARKIRFEINRFELPIGVQGLFGLIRHPGASLAVPITADGRVVVLRQYRFAVARRILE
FPAGTLEDGEDPQASMERELAEEAGYSAARWDSLGQMLPCPGYSDEVIHLFLARDLKALSESPAGDEDEDLEVLHMTPAE
FDACLASGDEALDGKSITAWYRARQLLGL

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 20731; Mature: 20731

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNMVPLPPPEPSLLLETTAALEARKIRFEINRFELPIGVQGLFGLIRHPGASLAVPITA
CCCCCCCCCCCCCEEEHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEC
DGRVVVLRQYRFAVARRILEFPAGTLEDGEDPQASMERELAEEAGYSAARWDSLGQMLPC
CCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCC
PGYSDEVIHLFLARDLKALSESPAGDEDEDLEVLHMTPAEFDACLASGDEALDGKSITAW
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCHHHH
YRARQLLGL
HHHHHHHCC
>Mature Secondary Structure
MVNMVPLPPPEPSLLLETTAALEARKIRFEINRFELPIGVQGLFGLIRHPGASLAVPITA
CCCCCCCCCCCCCEEEHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEC
DGRVVVLRQYRFAVARRILEFPAGTLEDGEDPQASMERELAEEAGYSAARWDSLGQMLPC
CCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCC
PGYSDEVIHLFLARDLKALSESPAGDEDEDLEVLHMTPAEFDACLASGDEALDGKSITAW
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCHHHH
YRARQLLGL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]