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The map label for this gene is hisB

Identifier: 124024201

GI number: 124024201

Start: 2209324

End: 2209953

Strand: Reverse

Name: hisB

Synonym: P9303_25121

Alternate gene names: 124024201

Gene position: 2209953-2209324 (Counterclockwise)

Preceding gene: 124024202

Following gene: 124024200

Centisome position: 82.38

GC content: 55.4

Gene sequence:

>630_bases
ATGGGCATCATGACGTCGCTAAGGCAGGGGGATGTTCATCGCGTCACCGCTGAAACCGACGTGCTTGTTCGTGTTGGGCT
TGATGGCTGTGGTCAGTGCAACGTTTCTACGGGGGTCGCCTTCCTCGATCACATGCTTCACCAGCTTTCCAGCCATGGCC
TGCTGGATTTAGAGATCACCGCGACTGGTGACACCCACATCGATGACCATCACACCAATGAGGATGTGGGTATAGCTGTT
GGTCAGGCCCTATCTCAGGCCCTTGGAGATCGACGTGGCATCCACCGCTTCGGTCATTTTGTGGCACCACTCGATGAGGC
GTTGGTTCAGGTCGTTCTGGATTGCTCCGGTAGGCCACATTTCAGTTATGGCCTGCAAATTCCCTCTCAGCGAATTGGTA
GTTACGACAGCGAGTTGGTGAAGGAGTTCTTCGTGGCAGTTGTTAACAACAGCGGCCTCACCCTGCATATTCGTCAGTTG
GCAGGCACCAATTCCCACCACATCGTTGAAGCTTGTTTCAAGGCCTTTGCCAGAGCTCTGCGCATGGCAATTGAAATCGA
CCCGCGAAGGGCCGGTGCAGTACCAAGCAGCAAGGGTGTGCTGGAGCAGGCTGGCGGGCAGAAGAGCTGA

Upstream 100 bases:

>100_bases
GAGCGATCTTTCCAGTGGGATCTCCGGTCAGACGCTTTATGTGGATGCTGGTTACTGCATTAACGGAATGTGATTTGACT
GGCAGCATGACTTCATTTGG

Downstream 100 bases:

>100_bases
ATGCTTTGGGAGTGGGGATTTCCTCGCTCGCGGCTGTAAGCCCTTTTGCGTAAGGATTGGTCAATCTTGATCAGCCTTGC
AGTGAGCACAGTGAGCGATA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEITATGDTHIDDHHTNEDVGIAV
GQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPHFSYGLQIPSQRIGSYDSELVKEFFVAVVNNSGLTLHIRQL
AGTNSHHIVEACFKAFARALRMAIEIDPRRAGAVPSSKGVLEQAGGQKS

Sequences:

>Translated_209_residues
MGIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEITATGDTHIDDHHTNEDVGIAV
GQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPHFSYGLQIPSQRIGSYDSELVKEFFVAVVNNSGLTLHIRQL
AGTNSHHIVEACFKAFARALRMAIEIDPRRAGAVPSSKGVLEQAGGQKS
>Mature_208_residues
GIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEITATGDTHIDDHHTNEDVGIAVG
QALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPHFSYGLQIPSQRIGSYDSELVKEFFVAVVNNSGLTLHIRQLA
GTNSHHIVEACFKAFARALRMAIEIDPRRAGAVPSSKGVLEQAGGQKS

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=48.9690721649485, Blast_Score=184, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=168, Percent_Identity=47.0238095238095, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PROM3 (A2CCN3)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018508.1
- ProteinModelPortal:   A2CCN3
- SMR:   A2CCN3
- STRING:   A2CCN3
- GeneID:   4777718
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_25121
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22480; Mature: 22349

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEIT
CCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
ATGDTHIDDHHTNEDVGIAVGQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPH
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
FSYGLQIPSQRIGSYDSELVKEFFVAVVNNSGLTLHIRQLAGTNSHHIVEACFKAFARAL
CEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHH
RMAIEIDPRRAGAVPSSKGVLEQAGGQKS
HHHHEECCHHCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
GIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEIT
CCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
ATGDTHIDDHHTNEDVGIAVGQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPH
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
FSYGLQIPSQRIGSYDSELVKEFFVAVVNNSGLTLHIRQLAGTNSHHIVEACFKAFARAL
CEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHH
RMAIEIDPRRAGAVPSSKGVLEQAGGQKS
HHHHEECCHHCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA